======= NME6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NME6
  * **<color #00a2e8>Official Name</color>**: NME/NM23 nucleoside diphosphate kinase 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10201|10201]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75414|O75414]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NME6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NME6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608294|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NDK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UTP biosynthetic process|
|UTP metabolic process|
|GTP biosynthetic process|
|guanosine-containing compound biosynthetic process|
|CTP biosynthetic process|
|CTP metabolic process|
|pyrimidine ribonucleoside triphosphate biosynthetic process|
|pyrimidine ribonucleoside triphosphate metabolic process|
|pyrimidine nucleoside triphosphate biosynthetic process|
|nucleoside diphosphate kinase activity|
|pyrimidine ribonucleotide biosynthetic process|
|purine ribonucleoside biosynthetic process|
|ribonucleoside biosynthetic process|
|pyrimidine nucleoside triphosphate metabolic process|
|purine nucleoside biosynthetic process|
|pyrimidine ribonucleotide metabolic process|
|GTP metabolic process|
|nucleoside biosynthetic process|
|negative regulation of mitotic nuclear division|
|guanosine-containing compound metabolic process|
|glycosyl compound biosynthetic process|
|purine ribonucleoside triphosphate biosynthetic process|
|pyrimidine nucleotide biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|negative regulation of nuclear division|
|ribonucleoside triphosphate biosynthetic process|
|pyrimidine-containing compound biosynthetic process|
|nucleoside diphosphate phosphorylation|
|purine ribonucleoside triphosphate metabolic process|
|purine ribonucleoside metabolic process|
|nucleotide phosphorylation|
|pyrimidine nucleotide metabolic process|
|nucleoside triphosphate biosynthetic process|
|purine nucleoside metabolic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|ribonucleoside metabolic process|
|nucleoside diphosphate metabolic process|
|nucleoside triphosphate metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|pyrimidine-containing compound metabolic process|
|nucleoside metabolic process|
|glycosyl compound metabolic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|regulation of mitotic nuclear division|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|negative regulation of cell growth|
|regulation of nuclear division|
|negative regulation of growth|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|negative regulation of mitotic cell cycle|
|purine ribonucleotide metabolic process|
|negative regulation of cell cycle process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|negative regulation of organelle organization|
|regulation of cell growth|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|negative regulation of cell cycle|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|regulation of mitotic cell cycle|
|regulation of growth|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|organophosphate metabolic process|
|apoptotic process|
|carbohydrate derivative metabolic process|
|programmed cell death|
|cell death|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|mitochondrion|
|phosphorylation|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp358|FK-506 5μM R07 exp358]]|-3.44|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.43|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-2.42|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-2.37|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.36|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-2.33|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-2.32|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.27|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-2.26|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-2.07|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.83|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.82|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.78|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.77|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.77|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.76|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.74|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.71|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.7|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.74|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.83|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.43|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cox7a2l|COX7A2L]]|0.442|
|[[:human genes:s:slc25a33|SLC25A33]]|0.425|
|[[:human genes:m:mgme1|MGME1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19064
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NME6 Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>