======= NMT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NMT1
  * **<color #00a2e8>Official Name</color>**: N-myristoyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4836|4836]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30419|P30419]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NMT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NMT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/160993|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. {ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:9353336, ECO:0000269|PubMed:9506952}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NMT|
|NMT C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myristoyltransferase activity|
|glycylpeptide N-tetradecanoyltransferase activity|
|N-terminal peptidyl-glycine N-myristoylation|
|peptidyl-glycine modification|
|protein myristoylation|
|N-terminal protein myristoylation|
|N-terminal protein lipidation|
|regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|regulation of rhodopsin mediated signaling pathway|
|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|N-terminal protein amino acid modification|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|positive regulation of establishment of protein localization to mitochondrion|
|extrinsic component of membrane|
|cellular ketone metabolic process|
|regulation of mitochondrial membrane permeability|
|regulation of establishment of protein localization to mitochondrion|
|regulation of membrane permeability|
|protein lipidation|
|lipoprotein biosynthetic process|
|positive regulation of mitochondrion organization|
|lipoprotein metabolic process|
|positive regulation of protein localization to membrane|
|mitochondrial membrane organization|
|regulation of G protein-coupled receptor signaling pathway|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|protein acylation|
|regulation of protein localization to membrane|
|mitochondrial transport|
|positive regulation of cellular protein localization|
|in utero embryonic development|
|regulation of apoptotic signaling pathway|
|mitochondrion organization|
|positive regulation of establishment of protein localization|
|regulation of cellular protein localization|
|positive regulation of organelle organization|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|positive regulation of cell death|
|regulation of establishment of protein localization|
|membrane organization|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|embryo development|
|positive regulation of transport|
|regulation of protein localization|
|regulation of response to external stimulus|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of organelle organization|
|organonitrogen compound biosynthetic process|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.68|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.44|
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.32|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.26|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.08|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.06|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-2.06|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.99|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.98|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.95|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.76|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.71|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.7|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.88|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 353/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|14/28|
|blood|15/28|
|bone|11/26|
|breast|16/33|
|central nervous system|22/56|
|cervix|2/4|
|colorectal|12/17|
|esophagus|9/13|
|fibroblast|0/1|
|gastric|11/16|
|kidney|2/21|
|liver|11/20|
|lung|33/75|
|lymphocyte|11/16|
|ovary|10/26|
|pancreas|12/24|
|peripheral nervous system|6/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|10/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|17/22|
|urinary tract|19/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1976
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NMT1 Expression in NALM6 Cells: 7.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>