======= NMUR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NMUR2
  * **<color #00a2e8>Official Name</color>**: neuromedin U receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56923|56923]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZQ4|Q9GZQ4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NMUR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NMUR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605108|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for the neuromedin-U and neuromedin-S neuropeptides. {ECO:0000250, ECO:0000269|PubMed:10899166}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuromedin U binding|
|neuromedin U receptor activity|
|activation of phospholipase A2 activity by calcium-mediated signaling|
|activation of phospholipase A2 activity|
|reduction of food intake in response to dietary excess|
|positive regulation of phospholipase A2 activity|
|regulation of phospholipase A2 activity|
|grooming behavior|
|intracellular calcium activated chloride channel activity|
|inositol phosphate-mediated signaling|
|arachidonate transport|
|arachidonic acid secretion|
|response to dietary excess|
|icosanoid secretion|
|eating behavior|
|response to pain|
|icosanoid transport|
|fatty acid derivative transport|
|regulation of sensory perception of pain|
|regulation of sensory perception|
|long-chain fatty acid transport|
|positive regulation of phospholipase activity|
|regulation of smooth muscle contraction|
|multicellular organismal response to stress|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|fatty acid transport|
|acid secretion|
|feeding behavior|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of lipase activity|
|neuropeptide signaling pathway|
|regulation of nervous system process|
|monocarboxylic acid transport|
|calcium-mediated signaling|
|regulation of muscle contraction|
|regulation of muscle system process|
|calcium ion transport|
|positive regulation of cytosolic calcium ion concentration|
|carboxylic acid transport|
|organic acid transport|
|divalent metal ion transport|
|lipid transport|
|divalent inorganic cation transport|
|lipid localization|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|GTP binding|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|organic anion transport|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|response to nutrient levels|
|response to extracellular stimulus|
|cellular metal ion homeostasis|
|behavior|
|anion transport|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|central nervous system development|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|transmembrane transport|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|ion transport|
|positive regulation of catalytic activity|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.82|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.73|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8712
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NMUR2 Expression in NALM6 Cells: -1.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>