======= NNT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NNT
  * **<color #00a2e8>Official Name</color>**: nicotinamide nucleotide transhydrogenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23530|23530]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13423|Q13423]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NNT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NNT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607878|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland. {ECO:0000269|PubMed:22634753}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AlaDh PNT C|
|DUF3814|
|AlaDh PNT N|
|PNTB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NAD(P)+ transhydrogenase (B-specific) activity|
|NAD(P)+ transhydrogenase activity|
|positive regulation of hydrogen peroxide catabolic process|
|regulation of hydrogen peroxide catabolic process|
|positive regulation of hydrogen peroxide metabolic process|
|oxygen homeostasis|
|positive regulation of cofactor metabolic process|
|positive regulation of mitochondrial membrane potential|
|gas homeostasis|
|mitochondrial respirasome|
|NADPH regeneration|
|positive regulation of membrane potential|
|regulation of hydrogen peroxide metabolic process|
|NADP metabolic process|
|tricarboxylic acid cycle|
|regulation of cofactor metabolic process|
|NADP binding|
|NAD binding|
|regulation of mitochondrial membrane potential|
|cell redox homeostasis|
|aerobic respiration|
|response to vitamin|
|cellular oxidant detoxification|
|positive regulation of reactive oxygen species metabolic process|
|cellular detoxification|
|reactive oxygen species metabolic process|
|detoxification|
|proton transmembrane transport|
|cellular respiration|
|regulation of reactive oxygen species metabolic process|
|cellular response to toxic substance|
|response to nutrient|
|energy derivation by oxidation of organic compounds|
|positive regulation of cellular catabolic process|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|negative regulation of protein phosphorylation|
|generation of precursor metabolites and energy|
|regulation of membrane potential|
|positive regulation of catabolic process|
|negative regulation of phosphorylation|
|response to nutrient levels|
|response to toxic substance|
|response to extracellular stimulus|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|inorganic cation transmembrane transport|
|negative regulation of protein modification process|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|cation transport|
|regulation of cellular catabolic process|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|ion transmembrane transport|
|oxidation-reduction process|
|regulation of catabolic process|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|mitochondrion|
|transmembrane transport|
|ion transport|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|homeostatic process|
|regulation of cell death|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.83|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.17|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.88|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.83|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.79|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.77|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.75|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.74|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|1.79|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.8|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2639
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NNT Expression in NALM6 Cells: 8.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>