======= NOA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOA1
  * **<color #00a2e8>Official Name</color>**: nitric oxide associated 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84273|84273]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NC60|Q8NC60]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614919|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP. {ECO:0000269|PubMed:19103604}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extrinsic component of mitochondrial inner membrane|
|regulation of cellular respiration|
|mitochondrial translation|
|mitochondrial gene expression|
|regulation of generation of precursor metabolites and energy|
|translation|
|GTP binding|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|apoptotic process|
|programmed cell death|
|cell death|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.71|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.89|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.9|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.493|
|[[:human genes:n:ndufa3|NDUFA3]]|0.481|
|[[:human genes:n:ndufs2|NDUFS2]]|0.469|
|[[:human genes:f:fastkd2|FASTKD2]]|0.467|
|[[:human genes:a:acad9|ACAD9]]|0.464|
|[[:human genes:c:c12orf65|C12orf65]]|0.463|
|[[:human genes:m:mtif2|MTIF2]]|0.461|
|[[:human genes:s:sfxn4|SFXN4]]|0.459|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.453|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.451|
|[[:human genes:g:grsf1|GRSF1]]|0.45|
|[[:human genes:m:mettl17|METTL17]]|0.444|
|[[:human genes:n:ndufa13|NDUFA13]]|0.443|
|[[:human genes:m:mto1|MTO1]]|0.442|
|[[:human genes:n:nubpl|NUBPL]]|0.442|
|[[:human genes:n:ndufb11|NDUFB11]]|0.442|
|[[:human genes:n:ndufb7|NDUFB7]]|0.436|
|[[:human genes:n:ndufa1|NDUFA1]]|0.435|
|[[:human genes:m:mrpl45|MRPL45]]|0.427|
|[[:human genes:n:ndufb4|NDUFB4]]|0.427|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.426|
|[[:human genes:n:ndufa2|NDUFA2]]|0.425|
|[[:human genes:r:rmnd1|RMND1]]|0.423|
|[[:human genes:m:mrp63|MRP63]]|0.422|
|[[:human genes:r:rpusd3|RPUSD3]]|0.422|
|[[:human genes:n:ndufa11|NDUFA11]]|0.421|
|[[:human genes:l:lars2|LARS2]]|0.42|
|[[:human genes:f:foxred1|FOXRED1]]|0.417|
|[[:human genes:c:clpp|CLPP]]|0.417|
|[[:human genes:n:ndufb9|NDUFB9]]|0.416|
|[[:human genes:n:ndufb6|NDUFB6]]|0.414|
|[[:human genes:y:yars2|YARS2]]|0.413|
|[[:human genes:m:mrps21|MRPS21]]|0.409|
|[[:human genes:f:ftsj2|FTSJ2]]|0.409|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.407|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.407|
|[[:human genes:n:ndufc1|NDUFC1]]|0.407|
|[[:human genes:n:ndufa8|NDUFA8]]|0.405|
|[[:human genes:n:ndufb2|NDUFB2]]|0.402|
|[[:human genes:p:pet117|PET117]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|3/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2518
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOA1 Expression in NALM6 Cells: 5.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>