======= NOD1 =======
== Gene Information ==
* **Official Symbol**: NOD1
* **Official Name**: nucleotide binding oligomerization domain containing 1
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10392|10392]]
* **UniProt**: [[https://www.uniprot.org/uniprot/Q9Y239|Q9Y239]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=NOD1&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOD1|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/605980|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017].
* **UniProt Summary**: Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection. {ECO:0000269|PubMed:11058605, ECO:0000269|PubMed:17054981, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:22672233}.
|NACHT|
|CARD|
|interleukin-8 biosynthetic process|
|positive regulation of xenophagy|
|regulation of xenophagy|
|positive regulation of dendritic cell antigen processing and presentation|
|interleukin-8 production|
|cellular response to muramyl dipeptide|
|positive regulation of antigen processing and presentation|
|regulation of dendritic cell antigen processing and presentation|
|detection of bacterium|
|cytokine biosynthetic process|
|detection of other organism|
|cytokine metabolic process|
|CARD domain binding|
|cysteine-type endopeptidase activator activity involved in apoptotic process|
|peptidoglycan binding|
|detection of external biotic stimulus|
|response to muramyl dipeptide|
|regulation of antigen processing and presentation|
|positive regulation of nitric-oxide synthase activity|
|detection of biotic stimulus|
|positive regulation of monooxygenase activity|
|nucleotide-binding oligomerization domain containing signaling pathway|
|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|
|cytoplasmic pattern recognition receptor signaling pathway|
|regulation of nitric-oxide synthase activity|
|positive regulation of interleukin-1 beta production|
|positive regulation of oxidoreductase activity|
|regulation of monooxygenase activity|
|positive regulation of interleukin-1 production|
|positive regulation of macroautophagy|
|positive regulation of NIK/NF-kappaB signaling|
|JNK cascade|
|regulation of interleukin-1 beta production|
|positive regulation of tumor necrosis factor production|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|defense response to Gram-positive bacterium|
|positive regulation of interleukin-6 production|
|regulation of interleukin-1 production|
|regulation of oxidoreductase activity|
|interleukin-1-mediated signaling pathway|
|stress-activated MAPK cascade|
|regulation of NIK/NF-kappaB signaling|
|positive regulation of autophagy|
|pattern recognition receptor signaling pathway|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of JNK cascade|
|regulation of interleukin-6 production|
|stress-activated protein kinase signaling cascade|
|regulation of tumor necrosis factor production|
|cytokine production|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of tumor necrosis factor superfamily cytokine production|
|activation of MAPK activity|
|intracellular receptor signaling pathway|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|positive regulation of endopeptidase activity|
|regulation of macroautophagy|
|cellular response to interleukin-1|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of JNK cascade|
|positive regulation of peptidase activity|
|basolateral plasma membrane|
|response to interleukin-1|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of stress-activated MAPK cascade|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|regulation of cysteine-type endopeptidase activity|
|activation of innate immune response|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of MAP kinase activity|
|protein-containing complex binding|
|regulation of ERK1 and ERK2 cascade|
|apical plasma membrane|
|cellular response to peptide|
|activation of protein kinase activity|
|defense response to bacterium|
|regulation of autophagy|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of innate immune response|
|regulation of MAP kinase activity|
|positive regulation of proteolysis|
|positive regulation of response to biotic stimulus|
|positive regulation of cellular catabolic process|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|cellular response to drug|
|regulation of endopeptidase activity|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|regulation of innate immune response|
|response to peptide|
|positive regulation of defense response|
|inflammatory response|
|positive regulation of multi-organism process|
|regulation of protein serine/threonine kinase activity|
|protein complex oligomerization|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|activation of immune response|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|response to bacterium|
|detection of stimulus|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|positive regulation of immune response|
|regulation of kinase activity|
|protein homodimerization activity|
|apoptotic process|
|defense response to other organism|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|response to nitrogen compound|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|immune response|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.74|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.37|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.67|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.74|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.74|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|3.49|
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 7139
* **Expression level (log2 read counts)**: 4.52
{{:chemogenomics:nalm6 dist.png?nolink |}}