======= NOL10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOL10
  * **<color #00a2e8>Official Name</color>**: nucleolar protein 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79954|79954]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BSC4|Q9BSC4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOL10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOL10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616197|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NUC153|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|small-subunit processome|
|maturation of SSU-rRNA|
|ribosomal small subunit biogenesis|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.71|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.72|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.77|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.88|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.96|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|3.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpl6|RPL6]]|0.557|
|[[:human genes:r:rps12|RPS12]]|0.556|
|[[:human genes:c:chd4|CHD4]]|0.549|
|[[:human genes:v:vasn|VASN]]|0.524|
|[[:human genes:t:timeless|TIMELESS]]|0.523|
|[[:human genes:r:rpl35|RPL35]]|0.517|
|[[:human genes:s:supt6h|SUPT6H]]|0.517|
|[[:human genes:t:tceb3c|TCEB3C]]|0.512|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.51|
|[[:human genes:r:rps7|RPS7]]|0.51|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.507|
|[[:human genes:p:prim1|PRIM1]]|0.502|
|[[:human genes:s:slc6a17|SLC6A17]]|0.502|
|[[:human genes:r:rps3a|RPS3A]]|0.501|
|[[:human genes:d:dtl|DTL]]|0.496|
|[[:human genes:t:ticrr|TICRR]]|0.495|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.495|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.489|
|[[:human genes:t:terf1|TERF1]]|0.488|
|[[:human genes:t:twistnb|TWISTNB]]|0.485|
|[[:human genes:r:rbm39|RBM39]]|0.484|
|[[:human genes:p:psmd3|PSMD3]]|0.477|
|[[:human genes:p:psmb4|PSMB4]]|0.475|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.475|
|[[:human genes:a:aamp|AAMP]]|0.475|
|[[:human genes:c:ctage4|CTAGE4]]|0.474|
|[[:human genes:k:kctd17|KCTD17]]|0.474|
|[[:human genes:p:psmc6|PSMC6]]|0.472|
|[[:human genes:b:bysl|BYSL]]|0.469|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.469|
|[[:human genes:a:arcn1|ARCN1]]|0.469|
|[[:human genes:o:orc6|ORC6]]|0.469|
|[[:human genes:o:ogfr|OGFR]]|0.468|
|[[:human genes:r:rrp15|RRP15]]|0.468|
|[[:human genes:p:pan3|PAN3]]|0.467|
|[[:human genes:w:wdr43|WDR43]]|0.465|
|[[:human genes:n:nupl1|NUPL1]]|0.465|
|[[:human genes:n:nop16|NOP16]]|0.463|
|[[:human genes:z:znf830|ZNF830]]|0.462|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.462|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.462|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.462|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.461|
|[[:human genes:c:c14orf93|C14orf93]]|0.461|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.461|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.46|
|[[:human genes:o:orc1|ORC1]]|0.46|
|[[:human genes:p:psma6|PSMA6]]|0.457|
|[[:human genes:p:pola1|POLA1]]|0.457|
|[[:human genes:p:ppan|PPAN]]|0.457|
|[[:human genes:c:copb1|COPB1]]|0.456|
|[[:human genes:p:psmd11|PSMD11]]|0.454|
|[[:human genes:m:mfsd12|MFSD12]]|0.454|
|[[:human genes:p:psmb1|PSMB1]]|0.453|
|[[:human genes:n:nbpf10|NBPF10]]|0.452|
|[[:human genes:s:sf3a3|SF3A3]]|0.452|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.452|
|[[:human genes:a:akt1s1|AKT1S1]]|0.451|
|[[:human genes:r:rps9|RPS9]]|0.45|
|[[:human genes:c:ccna2|CCNA2]]|0.45|
|[[:human genes:c:cep192|CEP192]]|0.449|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.449|
|[[:human genes:p:polr2d|POLR2D]]|0.448|
|[[:human genes:n:nop14|NOP14]]|0.447|
|[[:human genes:r:rpl34|RPL34]]|0.446|
|[[:human genes:c:cln6|CLN6]]|0.445|
|[[:human genes:p:pcf11|PCF11]]|0.445|
|[[:human genes:i:ik|IK]]|0.445|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.444|
|[[:human genes:r:rps2|RPS2]]|0.443|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.443|
|[[:human genes:r:rps28|RPS28]]|0.443|
|[[:human genes:p:pbxip1|PBXIP1]]|0.443|
|[[:human genes:b:brix1|BRIX1]]|0.442|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.442|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.442|
|[[:human genes:c:cbwd3|CBWD3]]|0.44|
|[[:human genes:p:psma7|PSMA7]]|0.44|
|[[:human genes:n:napa|NAPA]]|0.44|
|[[:human genes:p:polr1a|POLR1A]]|0.439|
|[[:human genes:p:pwp2|PWP2]]|0.439|
|[[:human genes:u:utp3|UTP3]]|0.438|
|[[:human genes:r:rnpc3|RNPC3]]|0.437|
|[[:human genes:d:ddx56|DDX56]]|0.437|
|[[:human genes:n:nol12|NOL12]]|0.437|
|[[:human genes:c:cope|COPE]]|0.436|
|[[:human genes:g:golga8o|GOLGA8O]]|0.436|
|[[:human genes:c:copg1|COPG1]]|0.436|
|[[:human genes:i:igfn1|IGFN1]]|0.435|
|[[:human genes:t:tfip11|TFIP11]]|0.435|
|[[:human genes:p:pan2|PAN2]]|0.434|
|[[:human genes:x:xylt2|XYLT2]]|0.432|
|[[:human genes:p:psmd14|PSMD14]]|0.432|
|[[:human genes:r:riok2|RIOK2]]|0.432|
|[[:human genes:c:cdc6|CDC6]]|0.431|
|[[:human genes:a:aqr|AQR]]|0.43|
|[[:human genes:o:osbp|OSBP]]|0.428|
|[[:human genes:p:psmb2|PSMB2]]|0.428|
|[[:human genes:s:supt5h|SUPT5H]]|0.427|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.427|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.427|
|[[:human genes:s:sult2b1|SULT2B1]]|0.426|
|[[:human genes:a:atp6ap2|ATP6AP2]]|0.424|
|[[:human genes:p:pole|POLE]]|0.424|
|[[:human genes:s:syt9|SYT9]]|0.424|
|[[:human genes:p:polr2h|POLR2H]]|0.424|
|[[:human genes:p:psmd7|PSMD7]]|0.423|
|[[:human genes:o:or10g3|OR10G3]]|0.423|
|[[:human genes:t:terf2|TERF2]]|0.422|
|[[:human genes:t:tgm5|TGM5]]|0.422|
|[[:human genes:p:pola2|POLA2]]|0.422|
|[[:human genes:k:krt78|KRT78]]|0.421|
|[[:human genes:s:snip1|SNIP1]]|0.42|
|[[:human genes:a:ankle2|ANKLE2]]|0.42|
|[[:human genes:c:c3orf17|C3orf17]]|0.42|
|[[:human genes:c:cbwd6|CBWD6]]|0.419|
|[[:human genes:t:tyms|TYMS]]|0.419|
|[[:human genes:r:rps3|RPS3]]|0.419|
|[[:human genes:m:myb|MYB]]|0.418|
|[[:human genes:u:utp20|UTP20]]|0.418|
|[[:human genes:s:sap30bp|SAP30BP]]|0.418|
|[[:human genes:c:cdh24|CDH24]]|0.417|
|[[:human genes:k:krt2|KRT2]]|0.417|
|[[:human genes:c:cdca3|CDCA3]]|0.417|
|[[:human genes:s:srfbp1|SRFBP1]]|0.417|
|[[:human genes:r:rps5|RPS5]]|0.417|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.417|
|[[:human genes:c:cbwd5|CBWD5]]|0.417|
|[[:human genes:m:med14|MED14]]|0.417|
|[[:human genes:c:copb2|COPB2]]|0.416|
|[[:human genes:e:exosc4|EXOSC4]]|0.416|
|[[:human genes:r:rffl|RFFL]]|0.416|
|[[:human genes:e:exosc9|EXOSC9]]|0.415|
|[[:human genes:p:psmd2|PSMD2]]|0.415|
|[[:human genes:c:chaf1a|CHAF1A]]|0.415|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.414|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.414|
|[[:human genes:c:ccdc116|CCDC116]]|0.414|
|[[:human genes:r:rad51|RAD51]]|0.413|
|[[:human genes:w:wdr87|WDR87]]|0.413|
|[[:human genes:s:ssh2|SSH2]]|0.412|
|[[:human genes:c:cdc73|CDC73]]|0.412|
|[[:human genes:k:kif3c|KIF3C]]|0.411|
|[[:human genes:r:rpl14|RPL14]]|0.409|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.409|
|[[:human genes:e:exosc3|EXOSC3]]|0.408|
|[[:human genes:v:vps28|VPS28]]|0.408|
|[[:human genes:n:npipb8|NPIPB8]]|0.408|
|[[:human genes:a:aatf|AATF]]|0.407|
|[[:human genes:g:gosr2|GOSR2]]|0.407|
|[[:human genes:c:cgb2|CGB2]]|0.407|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.407|
|[[:human genes:z:zfand5|ZFAND5]]|0.407|
|[[:human genes:d:dimt1|DIMT1]]|0.406|
|[[:human genes:t:tspy8|TSPY8]]|0.406|
|[[:human genes:e:exd1|EXD1]]|0.405|
|[[:human genes:f:fbxw9|FBXW9]]|0.405|
|[[:human genes:s:smg7|SMG7]]|0.405|
|[[:human genes:z:znf106|ZNF106]]|0.405|
|[[:human genes:r:rpl7|RPL7]]|0.405|
|[[:human genes:m:mki67ip|MKI67IP]]|0.404|
|[[:human genes:r:rps11|RPS11]]|0.403|
|[[:human genes:r:rpl31|RPL31]]|0.403|
|[[:human genes:d:ddtl|DDTL]]|0.402|
|[[:human genes:t:tspy2|TSPY2]]|0.402|
|[[:human genes:h:hist1h4b|HIST1H4B]]|0.402|
|[[:human genes:f:fam160a1|FAM160A1]]|0.402|
|[[:human genes:r:rnf113a|RNF113A]]|0.401|
|[[:human genes:n:npipb5|NPIPB5]]|0.4|
|[[:human genes:n:nxf1|NXF1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 728/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|26/28|
|bone|26/26|
|breast|30/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 723
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOL10 Expression in NALM6 Cells: 5.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>