======= NOL11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOL11
  * **<color #00a2e8>Official Name</color>**: nucleolar protein 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25926|25926]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H8H0|Q9H8H0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOL11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOL11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615366|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. {ECO:0000269|PubMed:22916032}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NUC205|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|t-UTP complex|
|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|
|regulation of transcription of nucleolar large rRNA by RNA polymerase I|
|positive regulation of transcription by RNA polymerase I|
|regulation of transcription by RNA polymerase I|
|maturation of SSU-rRNA|
|ribosomal small subunit biogenesis|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.28|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-2.16|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-1.85|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.76|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.72|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.71|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.71|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2377
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOL11 Expression in NALM6 Cells: 7.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>