======= NOL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOL3
  * **<color #00a2e8>Official Name</color>**: nucleolar protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8996|8996]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60936|O60936]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605235|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 1: May be involved in RNA splicing. {ECO:0000269|PubMed:10196175}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CARD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to injury involved in regulation of muscle adaptation|
|negative regulation of muscle atrophy|
|negative regulation of mitochondrial membrane permeability involved in apoptotic process|
|death effector domain binding|
|regulation of muscle atrophy|
|cardiac muscle cell apoptotic process|
|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway|
|striated muscle cell apoptotic process|
|regulation of hypoxia-induced intrinsic apoptotic signaling pathway|
|muscle cell apoptotic process|
|negative regulation of mitochondrial membrane permeability|
|negative regulation of cellular response to hypoxia|
|inhibition of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of membrane permeability|
|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|release of sequestered calcium ion into cytosol by endoplasmic reticulum|
|negative regulation of muscle adaptation|
|caspase binding|
|zymogen inhibition|
|inhibition of cysteine-type endopeptidase activity|
|regulation of cellular response to hypoxia|
|sarcoplasmic reticulum calcium ion transport|
|death receptor binding|
|response to stimulus involved in regulation of muscle adaptation|
|negative regulation of necrotic cell death|
|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of release of cytochrome c from mitochondria|
|negative regulation of tumor necrosis factor-mediated signaling pathway|
|negative regulation of cardiac muscle cell apoptotic process|
|regulation of mitochondrial membrane permeability involved in apoptotic process|
|negative regulation of striated muscle cell apoptotic process|
|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|
|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|regulation of necrotic cell death|
|mRNA splice site selection|
|blood vessel remodeling|
|negative regulation of protein processing|
|negative regulation of protein maturation|
|regulation of cardiac muscle cell apoptotic process|
|negative regulation of muscle cell apoptotic process|
|regulation of striated muscle cell apoptotic process|
|sarcoplasmic reticulum|
|negative regulation of cellular response to oxidative stress|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of response to oxidative stress|
|regulation of release of cytochrome c from mitochondria|
|response to ischemia|
|negative regulation of mitochondrion organization|
|release of sequestered calcium ion into cytosol|
|spliceosomal complex assembly|
|negative regulation of sequestering of calcium ion|
|regulation of tumor necrosis factor-mediated signaling pathway|
|apoptotic mitochondrial changes|
|negative regulation of cytokine-mediated signaling pathway|
|regulation of oxidative stress-induced cell death|
|negative regulation of response to cytokine stimulus|
|regulation of protein processing|
|calcium ion transmembrane import into cytosol|
|regulation of protein maturation|
|regulation of muscle cell apoptotic process|
|regulation of mitochondrial membrane permeability|
|calcium ion transport into cytosol|
|regulation of cellular response to oxidative stress|
|regulation of membrane permeability|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of response to oxidative stress|
|regulation of muscle adaptation|
|cytosolic calcium ion transport|
|negative regulation of cysteine-type endopeptidase activity|
|negative regulation of intrinsic apoptotic signaling pathway|
|tissue remodeling|
|negative regulation of extrinsic apoptotic signaling pathway|
|regulation of NIK/NF-kappaB signaling|
|regulation of sequestering of calcium ion|
|mitochondrial membrane organization|
|intrinsic apoptotic signaling pathway|
|regulation of extrinsic apoptotic signaling pathway|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|regulation of mitochondrion organization|
|calcium ion transmembrane transport|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|mitochondrial transport|
|negative regulation of apoptotic signaling pathway|
|ribonucleoprotein complex assembly|
|regulation of muscle system process|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|ribonucleoprotein complex subunit organization|
|calcium ion transport|
|negative regulation of peptidase activity|
|positive regulation of cytosolic calcium ion concentration|
|apoptotic signaling pathway|
|divalent metal ion transport|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|divalent inorganic cation transport|
|regulation of cytosolic calcium ion concentration|
|response to hypoxia|
|negative regulation of proteolysis|
|response to decreased oxygen levels|
|negative regulation of organelle organization|
|response to oxygen levels|
|RNA splicing|
|regulation of apoptotic signaling pathway|
|regulation of endopeptidase activity|
|cellular calcium ion homeostasis|
|mitochondrion organization|
|regulation of peptidase activity|
|calcium ion homeostasis|
|negative regulation of hydrolase activity|
|ribonucleoprotein complex biogenesis|
|cellular divalent inorganic cation homeostasis|
|mRNA processing|
|divalent inorganic cation homeostasis|
|negative regulation of intracellular signal transduction|
|protein complex oligomerization|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|response to wounding|
|regulation of system process|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|mRNA metabolic process|
|negative regulation of cellular component organization|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|regulation of proteolysis|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|ion homeostasis|
|negative regulation of catalytic activity|
|cation transport|
|cellular protein-containing complex assembly|
|membrane organization|
|nucleolus|
|RNA processing|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|apoptotic process|
|ion transmembrane transport|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|identical protein binding|
|cell death|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|negative regulation of molecular function|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|transmembrane transport|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|RNA binding|
|regulation of response to stress|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|homeostatic process|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|negative regulation of gene expression|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.99|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.93|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.85|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3903
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOL3 Expression in NALM6 Cells: 2.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>