======= NOL6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOL6
  * **<color #00a2e8>Official Name</color>**: nucleolar protein 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65083|65083]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H6R4|Q9H6R4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOL6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOL6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611532|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nrap|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CURI complex|
|UTP-C complex|
|condensed nuclear chromosome|
|tRNA export from nucleus|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA transport|
|small-subunit processome|
|ncRNA export from nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|protein export from nucleus|
|nuclear export|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|rRNA processing|
|RNA localization|
|rRNA metabolic process|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|intracellular protein transport|
|mitochondrion|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.84|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.74|
|[[:results:exp285|GW501516 25μM R06 exp285]]|1.77|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.78|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.83|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.97|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.99|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|2.24|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.491|
|[[:human genes:r:rrp15|RRP15]]|0.42|
|[[:human genes:b:bage2|BAGE2]]|0.415|
|[[:human genes:b:bage5|BAGE5]]|0.414|
|[[:human genes:b:bage4|BAGE4]]|0.414|
|[[:human genes:b:bage3|BAGE3]]|0.414|
|[[:human genes:b:bage|BAGE]]|0.414|
|[[:human genes:p:prim1|PRIM1]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 605/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|25/28|
|bone|21/26|
|breast|23/33|
|central nervous system|44/56|
|cervix|4/4|
|colorectal|11/17|
|esophagus|11/13|
|fibroblast|0/1|
|gastric|15/16|
|kidney|20/21|
|liver|17/20|
|lung|69/75|
|lymphocyte|11/16|
|ovary|21/26|
|pancreas|20/24|
|peripheral nervous system|11/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|21/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|14/22|
|urinary tract|21/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 88
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOL6 Expression in NALM6 Cells: 6.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>