======= NOL9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOL9
  * **<color #00a2e8>Official Name</color>**: nucleolar protein 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79707|79707]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5SY16|Q5SY16]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOL9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOL9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620304|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5'-kinase activities. Probably binds RNA. {ECO:0000269|PubMed:21063389}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Clp1|
|MobB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|polynucleotide 5-hydroxyl-kinase activity|
|cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|endonucleolytic cleavage involved in rRNA processing|
|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|maturation of LSU-rRNA|
|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|cleavage involved in rRNA processing|
|maturation of 5.8S rRNA|
|intermediate filament cytoskeleton|
|ribosomal large subunit biogenesis|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|RNA phosphodiester bond hydrolysis|
|rRNA processing|
|rRNA metabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|phosphorylation|
|RNA binding|
|ATP binding|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-3.28|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.96|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.7|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.71|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.74|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|1.76|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.84|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.89|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.96|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|2|
|[[:results:exp124|GSK343 3μM R03 exp124]]|2.01|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.02|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.22|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.24|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|2.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb4|PSMB4]]|0.469|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.459|
|[[:human genes:e:exosc6|EXOSC6]]|0.454|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.437|
|[[:human genes:r:rpl35|RPL35]]|0.433|
|[[:human genes:l:lad1|LAD1]]|0.429|
|[[:human genes:t:tceb3c|TCEB3C]]|0.428|
|[[:human genes:k:krt78|KRT78]]|0.428|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.428|
|[[:human genes:w:wdr75|WDR75]]|0.426|
|[[:human genes:p:psmb1|PSMB1]]|0.423|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.423|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.423|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.423|
|[[:human genes:s:sart1|SART1]]|0.423|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.421|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.417|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.411|
|[[:human genes:n:nsf|NSF]]|0.41|
|[[:human genes:c:cactin|CACTIN]]|0.406|
|[[:human genes:r:rpl34|RPL34]]|0.405|
|[[:human genes:r:rps7|RPS7]]|0.404|
|[[:human genes:m:myb|MYB]]|0.4|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 667/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|25/28|
|bone|20/26|
|breast|26/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|21/21|
|liver|15/20|
|lung|70/75|
|lymphocyte|14/16|
|ovary|21/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|27/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 783
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOL9 Expression in NALM6 Cells: 6.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>