======= NOLC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOLC1
  * **<color #00a2e8>Official Name</color>**: nucleolar and coiled-body phosphoprotein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9221|9221]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14978|Q14978]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOLC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOLC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602394|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SRP40 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|box H/ACA snoRNP complex binding|
|box C/D snoRNP complex binding|
|box C/D snoRNA binding|
|box H/ACA snoRNA metabolic process|
|box H/ACA snoRNA binding|
|box H/ACA snoRNP complex|
|RNA polymerase I core binding|
|nucleolus organization|
|box C/D snoRNP complex|
|neural crest formation|
|snoRNA metabolic process|
|nuclear localization sequence binding|
|Cajal body|
|regulation of protein import into nucleus|
|regulation of protein import|
|epithelial to mesenchymal transition|
|response to osmotic stress|
|neural crest cell development|
|mesenchymal cell development|
|stem cell development|
|neural crest cell differentiation|
|regulation of nucleocytoplasmic transport|
|regulation of protein localization to nucleus|
|nucleus organization|
|fibrillar center|
|mesenchymal cell differentiation|
|stem cell differentiation|
|rRNA processing|
|mesenchyme development|
|rRNA metabolic process|
|regulation of intracellular protein transport|
|protein domain specific binding|
|ribosome biogenesis|
|transcription factor binding|
|regulation of intracellular transport|
|regulation of translation|
|ncRNA processing|
|GTP binding|
|regulation of cellular amide metabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|protein heterodimerization activity|
|posttranscriptional regulation of gene expression|
|regulation of cellular protein localization|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|DNA-binding transcription factor activity|
|mitotic cell cycle|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|nucleolus|
|RNA processing|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|embryo development|
|regulation of protein localization|
|response to abiotic stimulus|
|cell cycle|
|RNA binding|
|DNA binding|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.95|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.88|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.87|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.73|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.73|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.73|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.78|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.78|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 35/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|2/26|
|breast|1/33|
|central nervous system|9/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3240
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOLC1 Expression in NALM6 Cells: 8.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>