======= NOP14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOP14
  * **<color #00a2e8>Official Name</color>**: NOP14 nucleolar protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8602|8602]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78316|P78316]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOP14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOP14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611526|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nop14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Noc4p-Nop14p complex|
|rRNA 5-end processing|
|endonucleolytic cleavage to generate mature 5-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|90S preribosome|
|endonucleolytic cleavage involved in rRNA processing|
|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|snoRNA binding|
|ncRNA 5-end processing|
|RNA 5-end processing|
|cleavage involved in rRNA processing|
|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|maturation of 5.8S rRNA|
|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|small-subunit processome|
|maturation of SSU-rRNA|
|ribosomal small subunit biogenesis|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|RNA phosphodiester bond hydrolysis|
|rRNA processing|
|rRNA metabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|enzyme binding|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.97|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.73|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.74|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|1.78|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.92|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.99|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.565|
|[[:human genes:r:rps2|RPS2]]|0.447|
|[[:human genes:n:nol10|NOL10]]|0.447|
|[[:human genes:r:rbbp5|RBBP5]]|0.439|
|[[:human genes:n:nsf|NSF]]|0.437|
|[[:human genes:r:rps28|RPS28]]|0.421|
|[[:human genes:r:rps12|RPS12]]|0.421|
|[[:human genes:p:pwp2|PWP2]]|0.417|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.416|
|[[:human genes:p:psmd11|PSMD11]]|0.404|
|[[:human genes:c:cactin|CACTIN]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 455/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|10/28|
|blood|17/28|
|bone|14/26|
|breast|23/33|
|central nervous system|37/56|
|cervix|2/4|
|colorectal|12/17|
|esophagus|9/13|
|fibroblast|0/1|
|gastric|11/16|
|kidney|12/21|
|liver|7/20|
|lung|49/75|
|lymphocyte|10/16|
|ovary|16/26|
|pancreas|13/24|
|peripheral nervous system|13/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|14/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|14/22|
|urinary tract|18/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1780
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOP14 Expression in NALM6 Cells: 7.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>