======= NOP16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOP16
  * **<color #00a2e8>Official Name</color>**: NOP16 nucleolar protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51491|51491]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3C1|Q9Y3C1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOP16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOP16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612861|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nop16|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosomal large subunit biogenesis|
|ribosome biogenesis|
|ribonucleoprotein complex biogenesis|
|intracellular membrane-bounded organelle|
|nucleolus|
|RNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp534|Trientine 500μM R08 exp534]]|-2.16|
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.98|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.87|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.81|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.78|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.7|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|1.71|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.72|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.84|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.84|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.87|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.96|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.96|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|2.02|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.03|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.06|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.13|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|2.16|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.18|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|2.2|
|[[:results:exp187|proTAME 5μM R04 exp187]]|2.21|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|2.25|
|[[:results:exp124|GSK343 3μM R03 exp124]]|2.25|
|[[:results:exp148|SB202190 10μM R03 exp148]]|2.39|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|2.53|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.68|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.522|
|[[:human genes:r:rps2|RPS2]]|0.522|
|[[:human genes:c:chd4|CHD4]]|0.515|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.505|
|[[:human genes:p:psma6|PSMA6]]|0.501|
|[[:human genes:s:scaf1|SCAF1]]|0.501|
|[[:human genes:r:rps28|RPS28]]|0.495|
|[[:human genes:p:psmd11|PSMD11]]|0.492|
|[[:human genes:r:rps7|RPS7]]|0.489|
|[[:human genes:p:pan3|PAN3]]|0.489|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.488|
|[[:human genes:d:ddtl|DDTL]]|0.487|
|[[:human genes:z:zfand5|ZFAND5]]|0.487|
|[[:human genes:p:psmb4|PSMB4]]|0.482|
|[[:human genes:s:supt6h|SUPT6H]]|0.482|
|[[:human genes:t:taf1|TAF1]]|0.479|
|[[:human genes:c:cdt1|CDT1]]|0.479|
|[[:human genes:a:aamp|AAMP]]|0.478|
|[[:human genes:r:rbbp5|RBBP5]]|0.477|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.473|
|[[:human genes:r:rps12|RPS12]]|0.473|
|[[:human genes:n:npipb8|NPIPB8]]|0.473|
|[[:human genes:m:myt1l|MYT1L]]|0.471|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.47|
|[[:human genes:c:ccna2|CCNA2]]|0.469|
|[[:human genes:c:cbwd3|CBWD3]]|0.468|
|[[:human genes:s:slc6a17|SLC6A17]]|0.467|
|[[:human genes:o:orc6|ORC6]]|0.467|
|[[:human genes:p:psmd14|PSMD14]]|0.467|
|[[:human genes:p:psma7|PSMA7]]|0.467|
|[[:human genes:r:rad51|RAD51]]|0.467|
|[[:human genes:c:cbwd5|CBWD5]]|0.465|
|[[:human genes:n:ndc80|NDC80]]|0.465|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.465|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.465|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.465|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.465|
|[[:human genes:n:nol10|NOL10]]|0.463|
|[[:human genes:v:vasn|VASN]]|0.463|
|[[:human genes:p:pcf11|PCF11]]|0.463|
|[[:human genes:m:mt1e|MT1E]]|0.463|
|[[:human genes:k:kctd17|KCTD17]]|0.462|
|[[:human genes:n:nupl1|NUPL1]]|0.462|
|[[:human genes:d:dtl|DTL]]|0.462|
|[[:human genes:d:disp2|DISP2]]|0.461|
|[[:human genes:n:npipb5|NPIPB5]]|0.459|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.458|
|[[:human genes:z:znf106|ZNF106]]|0.455|
|[[:human genes:m:myo1h|MYO1H]]|0.454|
|[[:human genes:r:rps3a|RPS3A]]|0.453|
|[[:human genes:m:myb|MYB]]|0.453|
|[[:human genes:d:ddx56|DDX56]]|0.452|
|[[:human genes:s:smg7|SMG7]]|0.452|
|[[:human genes:c:c14orf93|C14orf93]]|0.452|
|[[:human genes:p:paf1|PAF1]]|0.45|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.449|
|[[:human genes:p:psmd1|PSMD1]]|0.447|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.446|
|[[:human genes:a:atxn1|ATXN1]]|0.444|
|[[:human genes:r:ranbp2|RANBP2]]|0.443|
|[[:human genes:s:s1pr4|S1PR4]]|0.441|
|[[:human genes:r:rps9|RPS9]]|0.44|
|[[:human genes:r:rnf121|RNF121]]|0.439|
|[[:human genes:e:exosc5|EXOSC5]]|0.438|
|[[:human genes:u:uqcrh|UQCRH]]|0.438|
|[[:human genes:t:twistnb|TWISTNB]]|0.437|
|[[:human genes:s:smg1|SMG1]]|0.436|
|[[:human genes:p:ppm1d|PPM1D]]|0.435|
|[[:human genes:r:rpl14|RPL14]]|0.434|
|[[:human genes:t:tceb3c|TCEB3C]]|0.434|
|[[:human genes:k:krt2|KRT2]]|0.433|
|[[:human genes:s:ssh2|SSH2]]|0.433|
|[[:human genes:r:rpl35|RPL35]]|0.432|
|[[:human genes:r:rffl|RFFL]]|0.432|
|[[:human genes:h:hivep3|HIVEP3]]|0.431|
|[[:human genes:f:fcn2|FCN2]]|0.43|
|[[:human genes:c:copg1|COPG1]]|0.43|
|[[:human genes:c:ctr9|CTR9]]|0.429|
|[[:human genes:s:sf3a3|SF3A3]]|0.429|
|[[:human genes:r:rrn3|RRN3]]|0.428|
|[[:human genes:p:pan2|PAN2]]|0.428|
|[[:human genes:s:sfpq|SFPQ]]|0.427|
|[[:human genes:x:xylt2|XYLT2]]|0.427|
|[[:human genes:u:utp3|UTP3]]|0.426|
|[[:human genes:s:snip1|SNIP1]]|0.426|
|[[:human genes:m:med14|MED14]]|0.426|
|[[:human genes:a:akirin2|AKIRIN2]]|0.424|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.423|
|[[:human genes:p:polr2j3|POLR2J3]]|0.423|
|[[:human genes:p:pole|POLE]]|0.423|
|[[:human genes:t:tspy8|TSPY8]]|0.422|
|[[:human genes:p:psmc2|PSMC2]]|0.419|
|[[:human genes:z:znf830|ZNF830]]|0.418|
|[[:human genes:c:cdc73|CDC73]]|0.417|
|[[:human genes:r:rps11|RPS11]]|0.417|
|[[:human genes:a:art5|ART5]]|0.416|
|[[:human genes:n:narfl|NARFL]]|0.416|
|[[:human genes:t:top1mt|TOP1MT]]|0.416|
|[[:human genes:t:timeless|TIMELESS]]|0.415|
|[[:human genes:l:lrr1|LRR1]]|0.415|
|[[:human genes:m:med17|MED17]]|0.415|
|[[:human genes:g:gosr2|GOSR2]]|0.415|
|[[:human genes:r:rrm1|RRM1]]|0.413|
|[[:human genes:t:terf1|TERF1]]|0.412|
|[[:human genes:s:slc4a1|SLC4A1]]|0.412|
|[[:human genes:p:parp3|PARP3]]|0.412|
|[[:human genes:p:psmb1|PSMB1]]|0.41|
|[[:human genes:t:trim52|TRIM52]]|0.41|
|[[:human genes:r:rpl30|RPL30]]|0.41|
|[[:human genes:i:iscu|ISCU]]|0.409|
|[[:human genes:o:orc1|ORC1]]|0.409|
|[[:human genes:p:ppfia4|PPFIA4]]|0.408|
|[[:human genes:a:aqr|AQR]]|0.408|
|[[:human genes:s:ssfa2|SSFA2]]|0.408|
|[[:human genes:c:copb1|COPB1]]|0.408|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.407|
|[[:human genes:f:fam86b2|FAM86B2]]|0.407|
|[[:human genes:c:cbwd6|CBWD6]]|0.407|
|[[:human genes:r:rps20|RPS20]]|0.407|
|[[:human genes:p:psmd8|PSMD8]]|0.407|
|[[:human genes:r:rfxank|RFXANK]]|0.406|
|[[:human genes:w:wdr43|WDR43]]|0.406|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.405|
|[[:human genes:z:znf655|ZNF655]]|0.404|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.404|
|[[:human genes:a:adrm1|ADRM1]]|0.404|
|[[:human genes:o:ogfr|OGFR]]|0.403|
|[[:human genes:o:or10g3|OR10G3]]|0.403|
|[[:human genes:m:mdm2|MDM2]]|0.403|
|[[:human genes:n:nup133|NUP133]]|0.403|
|[[:human genes:c:cope|COPE]]|0.403|
|[[:human genes:e:exosc9|EXOSC9]]|0.402|
|[[:human genes:h:hinfp|HINFP]]|0.402|
|[[:human genes:d:ddt|DDT]]|0.401|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.401|
|[[:human genes:p:psmc1|PSMC1]]|0.401|
|[[:human genes:t:terf2|TERF2]]|0.4|
|[[:human genes:u:upf1|UPF1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 651/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|25/28|
|bone|25/26|
|breast|26/33|
|central nervous system|52/56|
|cervix|3/4|
|colorectal|15/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|21/21|
|liver|17/20|
|lung|62/75|
|lymphocyte|14/16|
|ovary|23/26|
|pancreas|22/24|
|peripheral nervous system|15/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|17/22|
|urinary tract|25/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 314
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOP16 Expression in NALM6 Cells: 5.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>