======= NOS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOS1
  * **<color #00a2e8>Official Name</color>**: nitric oxide synthase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4842|4842]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29475|P29475]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/163731|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
|NAD binding 1|
|FAD binding 1|
|Flavodoxin 1|
|NO synthase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process|
|retrograde trans-synaptic signaling by soluble gas|
|retrograde trans-synaptic signaling by nitric oxide|
|positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway|
|negative regulation of serotonin uptake|
|nitric-oxide synthase activity|
|ryanodine receptor complex|
|trans-synaptic signaling by soluble gas|
|trans-synaptic signaling by nitric oxide|
|regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process|
|synaptic signaling by nitric oxide|
|tetrahydrobiopterin binding|
|regulation of serotonin uptake|
|positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cadmium ion binding|
|positive regulation of the force of heart contraction|
|peptidyl-cysteine S-nitrosylation|
|protein nitrosylation|
|NADPH-hemoprotein reductase activity|
|negative regulation of neurotransmitter uptake|
|retrograde trans-synaptic signaling|
|arginine binding|
|positive regulation of guanylate cyclase activity|
|arginine catabolic process|
|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|
|regulation of guanylate cyclase activity|
|regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|nitric oxide biosynthetic process|
|FMN binding|
|arginine metabolic process|
|nitric oxide metabolic process|
|negative regulation of calcium ion transport into cytosol|
|regulation of neurotransmitter uptake|
|nitric oxide mediated signal transduction|
|reactive nitrogen species metabolic process|
|positive regulation of sodium ion transmembrane transport|
|positive regulation of nucleotide biosynthetic process|
|positive regulation of purine nucleotide biosynthetic process|
|positive regulation of cyclase activity|
|myoblast fusion|
|negative regulation of neurotransmitter transport|
|positive regulation of lyase activity|
|positive regulation of cAMP-mediated signaling|
|calyx of Held|
|reactive oxygen species biosynthetic process|
|regulation of ryanodine-sensitive calcium-release channel activity|
|glutamine family amino acid catabolic process|
|regulation of the force of heart contraction|
|positive regulation of G protein-coupled receptor signaling pathway|
|vesicle membrane|
|exogenous drug catabolic process|
|vasodilation|
|positive regulation of histone acetylation|
|negative regulation of potassium ion transport|
|positive regulation of peptidyl-lysine acetylation|
|sodium channel regulator activity|
|positive regulation of sodium ion transport|
|syncytium formation by plasma membrane fusion|
|cell-cell fusion|
|NADP binding|
|syncytium formation|
|peptidyl-cysteine modification|
|regulation of purine nucleotide biosynthetic process|
|regulation of nucleotide biosynthetic process|
|positive regulation of protein acetylation|
|regulation of cyclase activity|
|neurotransmitter biosynthetic process|
|T-tubule|
|sarcoplasmic reticulum|
|regulation of lyase activity|
|positive regulation of purine nucleotide metabolic process|
|positive regulation of nucleotide metabolic process|
|negative regulation of blood pressure|
|regulation of cAMP-mediated signaling|
|photoreceptor inner segment|
|regulation of histone acetylation|
|myotube differentiation|
|flavin adenine dinucleotide binding|
|positive regulation of blood vessel diameter|
|scaffold protein binding|
|negative regulation of calcium ion transport|
|regulation of peptidyl-lysine acetylation|
|regulation of sodium ion transmembrane transport|
|regulation of cardiac conduction|
|multicellular organismal response to stress|
|glutamine family amino acid metabolic process|
|regulation of protein acetylation|
|caveola|
|regulation of cardiac muscle contraction|
|cell redox homeostasis|
|regulation of release of sequestered calcium ion into cytosol|
|regulation of sodium ion transport|
|regulation of calcium ion transmembrane transporter activity|
|positive regulation of histone modification|
|regulation of striated muscle contraction|
|neurotransmitter metabolic process|
|regulation of potassium ion transport|
|regulation of calcium-mediated signaling|
|regulation of calcium ion transport into cytosol|
|sarcolemma|
|positive regulation of chromatin organization|
|positive regulation of peptidyl-serine phosphorylation|
|alpha-amino acid catabolic process|
|striated muscle contraction|
|response to heat|
|reactive oxygen species metabolic process|
|regulation of purine nucleotide metabolic process|
|oxidoreductase activity|
|regulation of nucleotide metabolic process|
|regulation of sequestering of calcium ion|
|cellular amino acid catabolic process|
|ion channel binding|
|Z disc|
|regulation of peptidyl-serine phosphorylation|
|positive regulation of small molecule metabolic process|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|positive regulation of cation transmembrane transport|
|heme binding|
|regulation of neurotransmitter transport|
|regulation of G protein-coupled receptor signaling pathway|
|drug catabolic process|
|regulation of histone modification|
|negative regulation of ion transport|
|regulation of calcium ion transmembrane transport|
|dendritic spine|
|positive regulation of ion transmembrane transport|
|regulation of muscle contraction|
|vascular process in circulatory system|
|regulation of cation channel activity|
|positive regulation of chromosome organization|
|response to temperature stimulus|
|regulation of blood pressure|
|regulation of chromatin organization|
|striated muscle cell differentiation|
|positive regulation of transmembrane transport|
|calmodulin binding|
|alpha-amino acid metabolic process|
|membrane raft|
|regulation of muscle system process|
|regulation of heart contraction|
|muscle cell differentiation|
|regulation of calcium ion transport|
|muscle contraction|
|postsynaptic density|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|synapse|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of blood circulation|
|muscle system process|
|cellular amino acid metabolic process|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|response to hypoxia|
|regulation of chromosome organization|
|regulation of neurotransmitter levels|
|response to decreased oxygen levels|
|cytoskeleton|
|response to oxygen levels|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|regulation of small molecule metabolic process|
|trans-synaptic signaling|
|small molecule catabolic process|
|negative regulation of hydrolase activity|
|synaptic signaling|
|muscle structure development|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|cellular response to growth factor stimulus|
|drug metabolic process|
|regulation of anatomical structure size|
|response to growth factor|
|regulation of transmembrane transport|
|regulation of system process|
|protein-containing complex|
|positive regulation of organelle organization|
|response to bacterium|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|negative regulation of catalytic activity|
|regulation of neurogenesis|
|response to lipid|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|response to hormone|
|carboxylic acid metabolic process|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|oxidation-reduction process|
|positive regulation of transport|
|oxoacid metabolic process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|organic acid metabolic process|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|mitochondrion|
|regulation of hydrolase activity|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11374
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOS1 Expression in NALM6 Cells: 3.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>