======= NOS1AP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOS1AP
  * **<color #00a2e8>Official Name</color>**: nitric oxide synthase 1 adaptor protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9722|9722]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75052|O75052]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOS1AP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOS1AP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605551|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PID|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of peptidyl-cysteine S-nitrosylation|
|positive regulation of membrane repolarization during cardiac muscle cell action potential|
|positive regulation of ventricular cardiac muscle cell action potential|
|positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential|
|positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|
|regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|
|inward rectifier potassium channel complex|
|positive regulation of delayed rectifier potassium channel activity|
|regulation of membrane repolarization during ventricular cardiac muscle cell action potential|
|positive regulation of actin filament-based movement|
|positive regulation of cardiac muscle cell contraction|
|positive regulation of nitric oxide mediated signal transduction|
|regulation of membrane repolarization during cardiac muscle cell action potential|
|regulation of heart rate by chemical signal|
|regulation of peptidyl-cysteine S-nitrosylation|
|regulation of membrane repolarization during action potential|
|positive regulation of action potential|
|regulation of nitric oxide mediated signal transduction|
|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|
|postsynaptic actin cytoskeleton organization|
|positive regulation of cardiac muscle contraction|
|L-type voltage-gated calcium channel complex|
|positive regulation of striated muscle contraction|
|nitric-oxide synthase binding|
|postsynaptic cytoskeleton organization|
|regulation of ventricular cardiac muscle cell action potential|
|positive regulation of voltage-gated potassium channel activity|
|regulation of high voltage-gated calcium channel activity|
|regulation of delayed rectifier potassium channel activity|
|positive regulation of nitric-oxide synthase activity|
|regulation of ventricular cardiac muscle cell membrane repolarization|
|positive regulation of potassium ion transmembrane transporter activity|
|positive regulation of monooxygenase activity|
|regulation of cardiac muscle cell membrane repolarization|
|regulation of cardiac muscle cell action potential|
|sarcoplasmic reticulum membrane|
|regulation of membrane repolarization|
|regulation of voltage-gated calcium channel activity|
|regulation of cardiac muscle cell contraction|
|positive regulation of potassium ion transmembrane transport|
|positive regulation of heart contraction|
|positive regulation of nitric oxide biosynthetic process|
|positive regulation of nitric oxide metabolic process|
|regulation of actin filament-based movement|
|T-tubule|
|regulation of nitric-oxide synthase activity|
|positive regulation of potassium ion transport|
|positive regulation of muscle contraction|
|regulation of action potential|
|positive regulation of reactive oxygen species biosynthetic process|
|positive regulation of oxidoreductase activity|
|regulation of monooxygenase activity|
|regulation of potassium ion transmembrane transporter activity|
|regulation of nitric oxide biosynthetic process|
|positive regulation of cation channel activity|
|positive regulation of blood circulation|
|caveola|
|regulation of cardiac muscle contraction|
|regulation of potassium ion transmembrane transport|
|regulation of reactive oxygen species biosynthetic process|
|regulation of calcium ion transmembrane transporter activity|
|postsynapse organization|
|regulation of striated muscle contraction|
|positive regulation of reactive oxygen species metabolic process|
|regulation of oxidoreductase activity|
|regulation of potassium ion transport|
|regulation of heart rate|
|sarcolemma|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|Z disc|
|positive regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transport|
|positive regulation of ion transmembrane transport|
|regulation of muscle contraction|
|regulation of cation channel activity|
|regulation of reactive oxygen species metabolic process|
|positive regulation of transmembrane transport|
|regulation of muscle system process|
|nuclear membrane|
|regulation of heart contraction|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|synapse organization|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of blood circulation|
|regulation of cation transmembrane transport|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|actin cytoskeleton organization|
|positive regulation of cellular component movement|
|regulation of transmembrane transport|
|actin filament-based process|
|regulation of system process|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|positive regulation of transport|
|regulation of cellular component movement|
|positive regulation of intracellular signal transduction|
|cytoskeleton organization|
|positive regulation of protein modification process|
|mitochondrion|
|positive regulation of catalytic activity|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.88|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9482
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.22 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOS1AP Expression in NALM6 Cells: 0.22'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>