======= NOS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOS2
  * **<color #00a2e8>Official Name</color>**: nitric oxide synthase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4843|4843]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35228|P35228]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/163730|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Flavodoxin 1|
|NO synthase|
|NAD binding 1|
|FAD binding 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nitric-oxide synthase activity|
|prostaglandin secretion|
|tetrahydrobiopterin binding|
|interleukin-8 secretion|
|interleukin-6 secretion|
|protein nitrosylation|
|NADPH-hemoprotein reductase activity|
|prostaglandin transport|
|peptidyl-cysteine S-nitrosylation|
|interleukin-8 production|
|arginine binding|
|arginine catabolic process|
|positive regulation of guanylate cyclase activity|
|interleukin-6 production|
|regulation of guanylate cyclase activity|
|nitric oxide biosynthetic process|
|positive regulation of killing of cells of other organism|
|FMN binding|
|nitric oxide metabolic process|
|regulation of killing of cells of other organism|
|arginine metabolic process|
|cortical cytoskeleton|
|innate immune response in mucosa|
|reactive nitrogen species metabolic process|
|nitric oxide mediated signal transduction|
|positive regulation of nucleotide biosynthetic process|
|positive regulation of purine nucleotide biosynthetic process|
|positive regulation of cyclase activity|
|positive regulation of lyase activity|
|reactive oxygen species biosynthetic process|
|glutamine family amino acid catabolic process|
|icosanoid secretion|
|vesicle membrane|
|mucosal immune response|
|regulation of cellular respiration|
|fatty acid derivative transport|
|icosanoid transport|
|organ or tissue specific immune response|
|NADP binding|
|peptidyl-cysteine modification|
|regulation of purine nucleotide biosynthetic process|
|superoxide metabolic process|
|regulation of nucleotide biosynthetic process|
|regulation of cytokine production involved in inflammatory response|
|regulation of cyclase activity|
|neurotransmitter biosynthetic process|
|positive regulation of nucleotide metabolic process|
|negative regulation of blood pressure|
|regulation of lyase activity|
|positive regulation of purine nucleotide metabolic process|
|cytokine secretion|
|peroxisomal matrix|
|positive regulation of leukocyte mediated cytotoxicity|
|flavin adenine dinucleotide binding|
|positive regulation of cell killing|
|protein localization to peroxisome|
|protein targeting to peroxisome|
|establishment of protein localization to peroxisome|
|glutamine family amino acid metabolic process|
|peroxisomal transport|
|fatty acid transport|
|cell redox homeostasis|
|regulation of leukocyte mediated cytotoxicity|
|peroxisome organization|
|acid secretion|
|defense response to Gram-negative bacterium|
|neurotransmitter metabolic process|
|regulation of cell killing|
|alpha-amino acid catabolic process|
|peroxisome|
|reactive oxygen species metabolic process|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|oxidoreductase activity|
|cellular amino acid catabolic process|
|negative regulation of protein catabolic process|
|monocarboxylic acid transport|
|positive regulation of small molecule metabolic process|
|circadian rhythm|
|heme binding|
|cytokine production|
|protein secretion|
|establishment of protein localization to extracellular region|
|regulation of generation of precursor metabolites and energy|
|cellular response to interferon-gamma|
|protein localization to extracellular region|
|peptide secretion|
|regulation of insulin secretion|
|response to interferon-gamma|
|regulation of blood pressure|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|calmodulin binding|
|alpha-amino acid metabolic process|
|regulation of peptide hormone secretion|
|cellular response to biotic stimulus|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|regulation of hormone secretion|
|rhythmic process|
|organic acid transport|
|carboxylic acid transport|
|lipid transport|
|negative regulation of catabolic process|
|cellular amino acid metabolic process|
|response to lipopolysaccharide|
|lipid localization|
|response to molecule of bacterial origin|
|defense response to bacterium|
|regulation of inflammatory response|
|second-messenger-mediated signaling|
|response to hypoxia|
|regulation of neurotransmitter levels|
|response to decreased oxygen levels|
|protein targeting|
|response to oxygen levels|
|regulation of protein catabolic process|
|blood circulation|
|circulatory system process|
|cellular response to drug|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|small molecule catabolic process|
|organic anion transport|
|regulation of protein secretion|
|regulation of peptide secretion|
|drug metabolic process|
|positive regulation of multi-organism process|
|cellular response to lipid|
|regulation of hormone levels|
|anion transport|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of secretion|
|response to lipid|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|cellular homeostasis|
|carboxylic acid metabolic process|
|response to hormone|
|defense response to other organism|
|oxidation-reduction process|
|intracellular protein transport|
|regulation of catabolic process|
|oxoacid metabolic process|
|secretion by cell|
|cellular response to cytokine stimulus|
|response to drug|
|organic acid metabolic process|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|ion transport|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|intracellular signal transduction|
|negative regulation of gene expression|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.87|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6535
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOS2 Expression in NALM6 Cells: -3.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>