======= NOS3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOS3
  * **<color #00a2e8>Official Name</color>**: nitric oxide synthase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4846|4846]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29474|P29474]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOS3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOS3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/163729|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FAD binding 1|
|NAD binding 1|
|NO synthase|
|Flavodoxin 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|muscle hyperplasia|
|smooth muscle hyperplasia|
|negative regulation of muscle hyperplasia|
|regulation of muscle hyperplasia|
|nitric-oxide synthase activity|
|smooth muscle adaptation|
|tetrahydrobiopterin binding|
|cadmium ion binding|
|regulation of systemic arterial blood pressure by endothelin|
|NADPH-hemoprotein reductase activity|
|regulation of the force of heart contraction by chemical signal|
|arginine binding|
|ovulation from ovarian follicle|
|positive regulation of guanylate cyclase activity|
|arginine catabolic process|
|negative regulation of muscle adaptation|
|regulation of guanylate cyclase activity|
|removal of superoxide radicals|
|nitric oxide biosynthetic process|
|cellular response to superoxide|
|cellular response to oxygen radical|
|FMN binding|
|pulmonary valve morphogenesis|
|arginine metabolic process|
|nitric oxide metabolic process|
|response to superoxide|
|ovulation|
|response to oxygen radical|
|negative regulation of platelet activation|
|nitric oxide mediated signal transduction|
|reactive nitrogen species metabolic process|
|pulmonary valve development|
|positive regulation of nucleotide biosynthetic process|
|positive regulation of cyclase activity|
|positive regulation of purine nucleotide biosynthetic process|
|positive regulation of lyase activity|
|reactive oxygen species biosynthetic process|
|glutamine family amino acid catabolic process|
|regulation of the force of heart contraction|
|negative regulation of biomineralization|
|actin monomer binding|
|negative regulation of biomineral tissue development|
|aortic valve morphogenesis|
|vesicle membrane|
|vasodilation|
|homeostasis of number of cells within a tissue|
|regulation of platelet activation|
|blood vessel remodeling|
|muscle adaptation|
|aortic valve development|
|negative regulation of potassium ion transport|
|response to fluid shear stress|
|lipopolysaccharide-mediated signaling pathway|
|endocardial cushion morphogenesis|
|NADP binding|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|regulation of systemic arterial blood pressure by hormone|
|semi-lunar valve development|
|superoxide metabolic process|
|regulation of purine nucleotide biosynthetic process|
|regulation of nucleotide biosynthetic process|
|ventricular septum morphogenesis|
|regulation of cyclase activity|
|ovulation cycle process|
|endocardial cushion development|
|neurotransmitter biosynthetic process|
|regulation of nitric-oxide synthase activity|
|positive regulation of purine nucleotide metabolic process|
|regulation of lyase activity|
|positive regulation of nucleotide metabolic process|
|negative regulation of blood pressure|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|negative regulation of blood coagulation|
|mesenchyme morphogenesis|
|negative regulation of hemostasis|
|positive regulation of Notch signaling pathway|
|negative regulation of coagulation|
|heart valve morphogenesis|
|regulation of monooxygenase activity|
|positive regulation of blood vessel endothelial cell migration|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|flavin adenine dinucleotide binding|
|positive regulation of blood vessel diameter|
|scaffold protein binding|
|negative regulation of calcium ion transport|
|heart valve development|
|endothelial cell migration|
|ovulation cycle|
|endocytic vesicle membrane|
|glutamine family amino acid metabolic process|
|negative regulation of wound healing|
|ventricular septum development|
|cardiac septum morphogenesis|
|caveola|
|cell redox homeostasis|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|epithelial cell migration|
|regulation of muscle adaptation|
|negative regulation of response to wounding|
|epithelium migration|
|regulation of sodium ion transport|
|female gonad development|
|regulation of blood vessel endothelial cell migration|
|cellular oxidant detoxification|
|neurotransmitter metabolic process|
|development of primary female sexual characteristics|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|regulation of systemic arterial blood pressure|
|tissue migration|
|regulation of oxidoreductase activity|
|regulation of potassium ion transport|
|positive regulation of endothelial cell migration|
|tissue remodeling|
|cellular detoxification|
|negative regulation of extrinsic apoptotic signaling pathway|
|regulation of Notch signaling pathway|
|alpha-amino acid catabolic process|
|female sex differentiation|
|response to heat|
|cardiac septum development|
|reactive oxygen species metabolic process|
|regulation of purine nucleotide metabolic process|
|oxidoreductase activity|
|regulation of nucleotide metabolic process|
|cellular amino acid catabolic process|
|cardiac chamber morphogenesis|
|detoxification|
|cardiac ventricle development|
|female gamete generation|
|cellular response to reactive oxygen species|
|regulation of nervous system process|
|positive regulation of small molecule metabolic process|
|regulation of wound healing|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|positive regulation of epithelial cell migration|
|heme binding|
|negative regulation of ion transport|
|regulation of extrinsic apoptotic signaling pathway|
|regulation of endothelial cell migration|
|positive regulation of angiogenesis|
|regulation of response to wounding|
|vascular process in circulatory system|
|lung development|
|cardiac chamber development|
|ameboidal-type cell migration|
|respiratory tube development|
|response to temperature stimulus|
|regulation of blood pressure|
|positive regulation of vasculature development|
|cellular response to lipopolysaccharide|
|tissue homeostasis|
|cellular response to molecule of bacterial origin|
|response to reactive oxygen species|
|respiratory system development|
|negative regulation of cell activation|
|homeostasis of number of cells|
|calmodulin binding|
|gonad development|
|alpha-amino acid metabolic process|
|cellular response to toxic substance|
|cellular response to biotic stimulus|
|development of primary sexual characteristics|
|regulation of epithelial cell migration|
|mesenchyme development|
|negative regulation of apoptotic signaling pathway|
|regulation of muscle system process|
|cellular response to oxidative stress|
|regulation of heart contraction|
|regulation of calcium ion transport|
|heart morphogenesis|
|sex differentiation|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|rhythmic process|
|regulation of angiogenesis|
|regulation of blood circulation|
|muscle system process|
|cellular amino acid metabolic process|
|response to lipopolysaccharide|
|angiogenesis|
|regulation of vasculature development|
|multicellular organismal homeostasis|
|response to molecule of bacterial origin|
|second-messenger-mediated signaling|
|anatomical structure homeostasis|
|regulation of neurotransmitter levels|
|negative regulation of response to external stimulus|
|cytoskeleton|
|in utero embryonic development|
|response to oxidative stress|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|regulation of apoptotic signaling pathway|
|blood vessel morphogenesis|
|reproductive structure development|
|regulation of small molecule metabolic process|
|reproductive system development|
|small molecule catabolic process|
|cofactor metabolic process|
|mitochondrion organization|
|negative regulation of hydrolase activity|
|negative regulation of transport|
|blood vessel development|
|regulation of body fluid levels|
|drug metabolic process|
|positive regulation of cell migration|
|response to toxic substance|
|vasculature development|
|regulation of anatomical structure size|
|cardiovascular system development|
|cellular response to lipid|
|positive regulation of cell motility|
|heart development|
|response to inorganic substance|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|tissue morphogenesis|
|regulation of system process|
|Golgi membrane|
|chordate embryonic development|
|regulation of cell activation|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|response to bacterium|
|gamete generation|
|regulation of ion transport|
|negative regulation of catalytic activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|response to lipid|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to hormone|
|carboxylic acid metabolic process|
|regulation of cell motility|
|negative regulation of developmental process|
|animal organ morphogenesis|
|oxidation-reduction process|
|cell migration|
|embryo development|
|regulation of locomotion|
|Golgi apparatus|
|negative regulation of cell death|
|multi-organism reproductive process|
|regulation of cellular component movement|
|oxoacid metabolic process|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8588
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOS3 Expression in NALM6 Cells: 2.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>