======= NOTCH2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOTCH2
  * **<color #00a2e8>Official Name</color>**: notch receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4853|4853]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q04721|Q04721]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOTCH2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOTCH2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600275|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NODP|
|EGF CA|
|Ank 2|
|Ank|
|NOD|
|DUF3454|
|EGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of growth rate|
|regulation of growth rate|
|marginal zone B cell differentiation|
|regulation of osteoclast development|
|Notch signaling involved in heart development|
|positive regulation of keratinocyte proliferation|
|atrial septum morphogenesis|
|pulmonary valve morphogenesis|
|mature B cell differentiation involved in immune response|
|pulmonary valve development|
|atrial septum development|
|regulation of bone development|
|cell surface receptor signaling pathway involved in heart development|
|mature B cell differentiation|
|cardiac atrium morphogenesis|
|regulation of keratinocyte proliferation|
|cardiac atrium development|
|regulation of actin cytoskeleton reorganization|
|semi-lunar valve development|
|cell fate determination|
|B cell activation involved in immune response|
|bone remodeling|
|heart valve morphogenesis|
|heart valve development|
|positive regulation of Ras protein signal transduction|
|regulation of osteoclast differentiation|
|positive regulation of small GTPase mediated signal transduction|
|cardiac septum morphogenesis|
|tissue remodeling|
|B cell differentiation|
|cardiac septum development|
|lymphocyte activation involved in immune response|
|regulation of myeloid leukocyte differentiation|
|Notch signaling pathway|
|cardiac chamber morphogenesis|
|stem cell population maintenance|
|maintenance of cell number|
|cell cycle arrest|
|B cell activation|
|cardiac chamber development|
|transcription initiation from RNA polymerase II promoter|
|positive regulation of epithelial cell proliferation|
|receptor complex|
|signaling receptor activity|
|positive regulation of ERK1 and ERK2 cascade|
|DNA-templated transcription, initiation|
|regulation of myeloid cell differentiation|
|lymphocyte differentiation|
|negative regulation of growth|
|regulation of Ras protein signal transduction|
|cell fate commitment|
|heart morphogenesis|
|regulation of leukocyte differentiation|
|regulation of ERK1 and ERK2 cascade|
|leukocyte differentiation|
|regulation of epithelial cell proliferation|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|lymphocyte activation|
|regulation of actin filament-based process|
|regulation of hemopoiesis|
|transcription by RNA polymerase II|
|heart development|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|hemopoiesis|
|negative regulation of cell cycle|
|hematopoietic or lymphoid organ development|
|cell surface|
|Golgi membrane|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|RNA biosynthetic process|
|regulation of growth|
|calcium ion binding|
|regulation of MAPK cascade|
|circulatory system development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|apoptotic process|
|leukocyte activation|
|regulation of cell development|
|endoplasmic reticulum membrane|
|animal organ morphogenesis|
|negative regulation of cell death|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|cell death|
|nucleobase-containing compound biosynthetic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of protein modification process|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|cell cycle|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|extracellular region|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.73|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.73|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.78|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|2|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.04|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vasn|VASN]]|0.41|
|[[:human genes:p:polr2j3|POLR2J3]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2650
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOTCH2 Expression in NALM6 Cells: 7.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>