======= NOTCH3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOTCH3
  * **<color #00a2e8>Official Name</color>**: notch receptor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4854|4854]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UM47|Q9UM47]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOTCH3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOTCH3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600276|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Notch|
|EGF CA|
|EGF|
|NOD|
|DUF3454|
|NODP|
|Ank|
|Ank 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glomerular capillary formation|
|glomerulus vasculature morphogenesis|
|renal system vasculature morphogenesis|
|kidney vasculature morphogenesis|
|glomerulus morphogenesis|
|positive regulation of transcription of Notch receptor target|
|glomerulus vasculature development|
|renal system vasculature development|
|kidney vasculature development|
|negative regulation of Notch signaling pathway|
|glomerulus development|
|artery morphogenesis|
|neuron fate commitment|
|artery development|
|positive regulation of smooth muscle cell proliferation|
|regulation of Notch signaling pathway|
|nephron development|
|Notch signaling pathway|
|regulation of smooth muscle cell proliferation|
|transcription initiation from RNA polymerase II promoter|
|receptor complex|
|signaling receptor activity|
|actin cytoskeleton|
|DNA-templated transcription, initiation|
|negative regulation of neuron differentiation|
|cell fate commitment|
|kidney development|
|renal system development|
|negative regulation of neurogenesis|
|cadherin binding|
|negative regulation of nervous system development|
|angiogenesis|
|urogenital system development|
|negative regulation of cell development|
|enzyme binding|
|forebrain development|
|blood vessel morphogenesis|
|transcription by RNA polymerase II|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|cell surface|
|Golgi membrane|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|tube morphogenesis|
|regulation of neuron differentiation|
|negative regulation of cell differentiation|
|calcium ion binding|
|brain development|
|head development|
|regulation of neurogenesis|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|central nervous system development|
|neuron differentiation|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp136|MS094 2μM R03 exp136]]|-1.87|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.72|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.7|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.73|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13874
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOTCH3 Expression in NALM6 Cells: 1.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>