======= NPIPB8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPIPB8
  * **<color #00a2e8>Official Name</color>**: nuclear pore complex interacting protein family member B8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=728734|728734]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/E9PQR5|E9PQR5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPIPB8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPIPB8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NPIP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-2.95|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-2.47|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.39|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.33|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.1|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.94|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.94|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.84|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.84|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.8|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.78|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.71|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.71|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.7|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.71|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.74|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.75|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.81|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.88|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.91|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.92|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.99|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2.1|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|2.23|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|2.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cope|COPE]]|0.537|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.53|
|[[:human genes:t:tceb3c|TCEB3C]]|0.522|
|[[:human genes:u:upf1|UPF1]]|0.519|
|[[:human genes:r:rpl6|RPL6]]|0.499|
|[[:human genes:p:pwp2|PWP2]]|0.494|
|[[:human genes:r:rad51|RAD51]]|0.488|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.486|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.485|
|[[:human genes:r:rps7|RPS7]]|0.478|
|[[:human genes:g:golga8o|GOLGA8O]]|0.475|
|[[:human genes:n:nop16|NOP16]]|0.473|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.469|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.466|
|[[:human genes:p:psma6|PSMA6]]|0.465|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.463|
|[[:human genes:s:stil|STIL]]|0.461|
|[[:human genes:t:ticrr|TICRR]]|0.453|
|[[:human genes:s:sf3a1|SF3A1]]|0.453|
|[[:human genes:c:cgb2|CGB2]]|0.451|
|[[:human genes:c:c14orf93|C14orf93]]|0.448|
|[[:human genes:c:cdc6|CDC6]]|0.448|
|[[:human genes:t:trim52|TRIM52]]|0.447|
|[[:human genes:r:rps2|RPS2]]|0.446|
|[[:human genes:p:plk1|PLK1]]|0.446|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.446|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.445|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.445|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.445|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.444|
|[[:human genes:t:twistnb|TWISTNB]]|0.441|
|[[:human genes:r:rps5|RPS5]]|0.44|
|[[:human genes:r:rps12|RPS12]]|0.437|
|[[:human genes:v:vasn|VASN]]|0.437|
|[[:human genes:m:myb|MYB]]|0.437|
|[[:human genes:p:psmc2|PSMC2]]|0.437|
|[[:human genes:p:psmd3|PSMD3]]|0.437|
|[[:human genes:c:cdc73|CDC73]]|0.436|
|[[:human genes:p:psma7|PSMA7]]|0.436|
|[[:human genes:p:psmb4|PSMB4]]|0.436|
|[[:human genes:k:krt78|KRT78]]|0.435|
|[[:human genes:e:exosc5|EXOSC5]]|0.435|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.435|
|[[:human genes:p:psmc5|PSMC5]]|0.435|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.435|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.434|
|[[:human genes:p:psmd1|PSMD1]]|0.433|
|[[:human genes:i:igfn1|IGFN1]]|0.433|
|[[:human genes:c:col2a1|COL2A1]]|0.432|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.431|
|[[:human genes:r:rilpl1|RILPL1]]|0.431|
|[[:human genes:s:sprr2b|SPRR2B]]|0.429|
|[[:human genes:c:cbwd3|CBWD3]]|0.429|
|[[:human genes:c:cdc45|CDC45]]|0.428|
|[[:human genes:p:paf1|PAF1]]|0.427|
|[[:human genes:r:rpl35|RPL35]]|0.427|
|[[:human genes:c:cbwd5|CBWD5]]|0.426|
|[[:human genes:t:timeless|TIMELESS]]|0.425|
|[[:human genes:p:psmd6|PSMD6]]|0.424|
|[[:human genes:l:lrr1|LRR1]]|0.424|
|[[:human genes:p:polr2j3|POLR2J3]]|0.423|
|[[:human genes:c:ccna2|CCNA2]]|0.422|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.422|
|[[:human genes:r:rad21|RAD21]]|0.422|
|[[:human genes:p:pbxip1|PBXIP1]]|0.419|
|[[:human genes:s:scaf1|SCAF1]]|0.419|
|[[:human genes:c:chd4|CHD4]]|0.419|
|[[:human genes:h:hap1|HAP1]]|0.418|
|[[:human genes:m:myo1h|MYO1H]]|0.418|
|[[:human genes:p:psmb2|PSMB2]]|0.417|
|[[:human genes:p:psmb3|PSMB3]]|0.417|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.416|
|[[:human genes:s:slc6a17|SLC6A17]]|0.415|
|[[:human genes:k:kctd17|KCTD17]]|0.414|
|[[:human genes:p:psmc6|PSMC6]]|0.412|
|[[:human genes:o:orc1|ORC1]]|0.412|
|[[:human genes:n:nol12|NOL12]]|0.412|
|[[:human genes:r:rps9|RPS9]]|0.411|
|[[:human genes:o:orc6|ORC6]]|0.41|
|[[:human genes:r:rps20|RPS20]]|0.409|
|[[:human genes:n:nup54|NUP54]]|0.409|
|[[:human genes:r:rbbp5|RBBP5]]|0.409|
|[[:human genes:c:cbwd6|CBWD6]]|0.408|
|[[:human genes:s:supt5h|SUPT5H]]|0.408|
|[[:human genes:p:psmb1|PSMB1]]|0.408|
|[[:human genes:n:nol10|NOL10]]|0.408|
|[[:human genes:m:mdm2|MDM2]]|0.407|
|[[:human genes:x:xylt2|XYLT2]]|0.405|
|[[:human genes:r:rrn3|RRN3]]|0.404|
|[[:human genes:c:c3orf22|C3orf22]]|0.404|
|[[:human genes:p:psmc1|PSMC1]]|0.404|
|[[:human genes:s:sprr2a|SPRR2A]]|0.403|
|[[:human genes:p:pola1|POLA1]]|0.402|
|[[:human genes:p:pole|POLE]]|0.402|
|[[:human genes:r:rps11|RPS11]]|0.402|
|[[:human genes:g:gjc3|GJC3]]|0.402|
|[[:human genes:d:ddx56|DDX56]]|0.402|
|[[:human genes:m:mt1e|MT1E]]|0.401|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1107
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPIPB8 Expression in NALM6 Cells: 1.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>