======= NPNT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPNT
  * **<color #00a2e8>Official Name</color>**: nephronectin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=255743|255743]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UXI9|Q6UXI9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPNT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPNT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610306|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EGF CA|
|EGF 3|
|MAM|
|cEGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|
|pilomotor reflex|
|integrin alpha8-beta1 complex|
|smooth muscle contractile fiber|
|cell-cell adhesion mediated by integrin|
|positive regulation of alkaline phosphatase activity|
|regulation of alkaline phosphatase activity|
|reflex|
|cell adhesion mediated by integrin|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|positive regulation of smooth muscle contraction|
|smooth muscle cell differentiation|
|positive regulation of phosphatase activity|
|branching involved in ureteric bud morphogenesis|
|positive regulation of muscle contraction|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|positive regulation of dephosphorylation|
|positive regulation of osteoblast differentiation|
|regulation of smooth muscle contraction|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|nephron tubule development|
|renal tubule development|
|kidney morphogenesis|
|positive regulation of ossification|
|ureteric bud development|
|mesonephric epithelium development|
|mesonephric tubule development|
|basement membrane|
|mesonephros development|
|nephron epithelium development|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of osteoblast differentiation|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|positive regulation of cell-substrate adhesion|
|nephron development|
|cell-matrix adhesion|
|kidney epithelium development|
|integrin binding|
|branching morphogenesis of an epithelial tube|
|extracellular matrix structural constituent|
|morphogenesis of a branching epithelium|
|regulation of muscle contraction|
|morphogenesis of a branching structure|
|regulation of phosphatase activity|
|cell-substrate adhesion|
|regulation of ossification|
|regulation of cell-substrate adhesion|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of dephosphorylation|
|regulation of muscle system process|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cellular response to tumor necrosis factor|
|muscle cell differentiation|
|response to tumor necrosis factor|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|renal system development|
|regulation of ERK1 and ERK2 cascade|
|epithelial tube morphogenesis|
|urogenital system development|
|extracellular matrix organization|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|positive regulation of cell adhesion|
|morphogenesis of an epithelium|
|muscle structure development|
|cell-cell adhesion|
|positive regulation of MAPK cascade|
|tissue morphogenesis|
|regulation of system process|
|tube morphogenesis|
|regulation of cell adhesion|
|calcium ion binding|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|tube development|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|response to cytokine|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8494
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPNT Expression in NALM6 Cells: -2.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>