======= NPPA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPPA
  * **<color #00a2e8>Official Name</color>**: natriuretic peptide A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4878|4878]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01160|P01160]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPPA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPPA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/108780|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. {ECO:0000269|PubMed:1672777}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ANP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of collecting lymphatic vessel constriction|
|neuropeptide receptor binding|
|regulation of collecting lymphatic vessel constriction|
|positive regulation of potassium ion export across plasma membrane|
|positive regulation of histamine secretion by mast cell|
|positive regulation of delayed rectifier potassium channel activity|
|hormone receptor binding|
|regulation of atrial cardiac muscle cell membrane repolarization|
|regulation of potassium ion export across plasma membrane|
|positive regulation of cGMP-mediated signaling|
|regulation of histamine secretion by mast cell|
|physiological cardiac muscle hypertrophy|
|physiological muscle hypertrophy|
|cell growth involved in cardiac muscle cell development|
|receptor guanylyl cyclase signaling pathway|
|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|
|cGMP biosynthetic process|
|positive regulation of cardiac muscle contraction|
|muscle hypertrophy in response to stress|
|positive regulation of striated muscle contraction|
|regulation of cGMP-mediated signaling|
|cardiac muscle adaptation|
|cardiac muscle hypertrophy in response to stress|
|regulation of high voltage-gated calcium channel activity|
|positive regulation of mast cell degranulation|
|positive regulation of mast cell activation involved in immune response|
|positive regulation of voltage-gated potassium channel activity|
|response to muscle stretch|
|cGMP metabolic process|
|negative regulation of systemic arterial blood pressure|
|regulation of delayed rectifier potassium channel activity|
|positive regulation of mast cell activation|
|mast cell granule|
|cyclic purine nucleotide metabolic process|
|cyclic nucleotide biosynthetic process|
|positive regulation of potassium ion transmembrane transporter activity|
|positive regulation of leukocyte degranulation|
|positive regulation of heart rate|
|cGMP-mediated signaling|
|regulation of cardiac muscle cell membrane repolarization|
|striated muscle adaptation|
|cardiac muscle tissue growth|
|neuropeptide hormone activity|
|heart growth|
|cardiac muscle hypertrophy|
|striated muscle hypertrophy|
|positive regulation of myeloid leukocyte mediated immunity|
|muscle hypertrophy|
|muscle adaptation|
|regulation of mast cell degranulation|
|regulation of membrane repolarization|
|regulation of voltage-gated calcium channel activity|
|regulation of mast cell activation involved in immune response|
|positive regulation of neurotransmitter transport|
|positive regulation of heart contraction|
|positive regulation of potassium ion transmembrane transport|
|cyclic nucleotide metabolic process|
|regulation of mast cell activation|
|positive regulation of potassium ion transport|
|positive regulation of muscle contraction|
|negative regulation of blood pressure|
|regulation of leukocyte degranulation|
|positive regulation of regulated secretory pathway|
|regulation of potassium ion transmembrane transporter activity|
|regulation of myeloid leukocyte mediated immunity|
|cardiac muscle cell development|
|cardiac cell development|
|regulation of cardiac conduction|
|positive regulation of cation channel activity|
|positive regulation of blood circulation|
|regulation of cardiac muscle contraction|
|cellular response to mechanical stimulus|
|regulation of potassium ion transmembrane transport|
|regulation of calcium ion transmembrane transporter activity|
|cardiac muscle cell differentiation|
|developmental cell growth|
|positive regulation of exocytosis|
|cell growth|
|regulation of striated muscle contraction|
|regulation of systemic arterial blood pressure|
|regulation of potassium ion transport|
|organ growth|
|regulation of heart rate|
|hormone activity|
|positive regulation of ion transmembrane transporter activity|
|neuropeptide signaling pathway|
|positive regulation of transporter activity|
|cardiocyte differentiation|
|positive regulation of hormone secretion|
|positive regulation of leukocyte mediated immunity|
|striated muscle cell development|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|positive regulation of inflammatory response|
|regulation of tube size|
|positive regulation of cation transmembrane transport|
|regulation of neurotransmitter transport|
|regulation of calcium ion transmembrane transport|
|muscle cell development|
|purine ribonucleotide biosynthetic process|
|positive regulation of ion transmembrane transport|
|purine nucleotide biosynthetic process|
|regulation of muscle contraction|
|ribonucleotide biosynthetic process|
|cardiac muscle tissue development|
|regulation of regulated secretory pathway|
|ribose phosphate biosynthetic process|
|vascular process in circulatory system|
|purine-containing compound biosynthetic process|
|cyclic-nucleotide-mediated signaling|
|regulation of cation channel activity|
|transcription initiation from RNA polymerase II promoter|
|female pregnancy|
|regulation of blood pressure|
|negative regulation of cell growth|
|striated muscle cell differentiation|
|positive regulation of transmembrane transport|
|regulation of leukocyte mediated immunity|
|positive regulation of intracellular transport|
|multi-multicellular organism process|
|response to mechanical stimulus|
|DNA-templated transcription, initiation|
|positive regulation of immune effector process|
|regulation of exocytosis|
|response to insulin|
|protein folding|
|regulation of muscle system process|
|negative regulation of growth|
|regulation of heart contraction|
|nucleotide biosynthetic process|
|muscle cell differentiation|
|nucleoside phosphate biosynthetic process|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of hormone secretion|
|positive regulation of ion transport|
|regulation of transporter activity|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle tissue development|
|muscle system process|
|purine ribonucleotide metabolic process|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|regulation of cation transmembrane transport|
|cellular response to external stimulus|
|signaling receptor binding|
|ribose phosphate metabolic process|
|second-messenger-mediated signaling|
|regulation of inflammatory response|
|response to hypoxia|
|regulation of intracellular transport|
|response to decreased oxygen levels|
|collagen-containing extracellular matrix|
|purine-containing compound metabolic process|
|response to oxygen levels|
|regulation of metal ion transport|
|developmental growth|
|blood circulation|
|response to peptide hormone|
|growth|
|circulatory system process|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|positive regulation of cell activation|
|regulation of cell growth|
|regulation of membrane potential|
|positive regulation of secretion|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|regulation of immune effector process|
|response to peptide|
|positive regulation of defense response|
|muscle structure development|
|regulation of ion transmembrane transport|
|transcription by RNA polymerase II|
|regulation of anatomical structure size|
|heart development|
|regulation of hormone levels|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|regulation of vesicle-mediated transport|
|regulation of transmembrane transport|
|regulation of system process|
|protein-containing complex|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|carbohydrate derivative biosynthetic process|
|transcription, DNA-templated|
|regulation of cell activation|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of growth|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|enzyme linked receptor protein signaling pathway|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of secretion|
|positive regulation of immune response|
|circulatory system development|
|organophosphate metabolic process|
|response to hormone|
|regulation of cellular localization|
|positive regulation of transport|
|multi-organism reproductive process|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|carbohydrate derivative metabolic process|
|response to nitrogen compound|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|extracellular space|
|cellular nitrogen compound biosynthetic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|RNA metabolic process|
|intracellular signal transduction|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|extracellular region|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-2.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12835
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPPA Expression in NALM6 Cells: -0.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>