======= NPRL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPRL3
  * **<color #00a2e8>Official Name</color>**: NPR3 like, GATOR1 complex subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8131|8131]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12980|Q12980]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPRL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPRL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600928|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The function of the encoded protein is not known. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. {ECO:0000269|PubMed:23723238}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NPR3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GATOR1 complex|
|TORC1 signaling|
|aorta morphogenesis|
|TOR signaling|
|regulation of autophagosome assembly|
|regulation of vacuole organization|
|cellular response to amino acid starvation|
|response to amino acid starvation|
|negative regulation of TOR signaling|
|aorta development|
|artery morphogenesis|
|ventricular septum development|
|artery development|
|roof of mouth development|
|regulation of TOR signaling|
|cardiac septum development|
|cardiac ventricle development|
|cellular response to starvation|
|cardiac muscle tissue development|
|cardiac chamber development|
|regulation of macroautophagy|
|response to starvation|
|regulation of organelle assembly|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|GTPase activator activity|
|striated muscle tissue development|
|muscle tissue development|
|lysosomal membrane|
|regulation of autophagy|
|cellular response to external stimulus|
|blood vessel morphogenesis|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|blood vessel development|
|response to nutrient levels|
|negative regulation of intracellular signal transduction|
|vasculature development|
|cardiovascular system development|
|heart development|
|response to extracellular stimulus|
|tube morphogenesis|
|positive regulation of hydrolase activity|
|regulation of cellular catabolic process|
|tube development|
|circulatory system development|
|regulation of cellular component biogenesis|
|regulation of catabolic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|negative regulation of response to stimulus|
|intracellular signal transduction|
|cellular response to stress|
|tissue development|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-4.93|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-4.35|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-4.03|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-3.71|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-3.56|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-3.54|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-3.4|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-3.39|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-3.36|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-3.35|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-3.34|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-3.2|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-3|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.99|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.98|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.97|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.96|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.93|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.92|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.82|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.82|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.75|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.74|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.7|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-2.66|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.6|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.58|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-2.57|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.54|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.54|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-2.53|
|[[:results:exp340|BN82002 4μM R07 exp340]]|-2.51|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.48|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-2.47|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.45|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.42|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.4|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.39|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-2.36|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.33|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-2.32|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.32|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.31|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.3|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.26|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.23|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.23|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.22|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.22|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.18|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.18|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-2.16|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.15|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.14|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-2.11|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-2.1|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-2.1|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-2.08|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-2.08|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-2.07|
|[[:results:exp275|Citral 75μM R06 exp275]]|-2.07|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.03|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.02|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.98|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.96|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.95|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.94|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.94|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.93|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.91|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.91|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.9|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.89|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.88|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.88|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.88|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.85|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.83|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.8|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.8|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.76|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.74|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.74|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.73|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.73|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|1.73|
|[[:results:exp483|FTY720 3μM R08 exp483]]|1.75|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.76|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.93|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.94|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.95|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.95|
|[[:results:exp124|GSK343 3μM R03 exp124]]|2|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|2.02|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|2.04|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|2.18|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.24|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|2.42|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.68|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.78|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.93|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.97|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|3.01|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|3.1|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.14|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|3.28|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|3.34|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|4.2|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|4.26|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|5.56|
|[[:results:exp504|MK2206 4μM R08 exp504]]|7.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nprl2|NPRL2]]|0.849|
|[[:human genes:d:depdc5|DEPDC5]]|0.839|
|[[:human genes:s:szt2|SZT2]]|0.826|
|[[:human genes:k:kptn|KPTN]]|0.729|
|[[:human genes:i:itfg2|ITFG2]]|0.722|
|[[:human genes:c:c12orf66|C12orf66]]|0.713|
|[[:human genes:s:sesn2|SESN2]]|0.656|
|[[:human genes:t:tsc2|TSC2]]|0.653|
|[[:human genes:t:tsc1|TSC1]]|0.627|
|[[:human genes:c:ccdc130|CCDC130]]|0.473|
|[[:human genes:z:zfp36l2|ZFP36L2]]|0.445|
|[[:human genes:p:prkaa1|PRKAA1]]|0.411|
|[[:human genes:a:anp32a|ANP32A]]|0.409|
|[[:human genes:h:hexim1|HEXIM1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14613
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPRL3 Expression in NALM6 Cells: 5.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>