======= NPSR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPSR1
  * **<color #00a2e8>Official Name</color>**: neuropeptide S receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=387129|387129]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6W5P4|Q6W5P4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPSR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPSR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608595|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vasopressin receptor activity|
|neuropeptide receptor activity|
|positive regulation of release of sequestered calcium ion into cytosol|
|positive regulation of calcium ion transport into cytosol|
|positive regulation of calcium ion transmembrane transport|
|regulation of release of sequestered calcium ion into cytosol|
|regulation of calcium ion transport into cytosol|
|neuropeptide signaling pathway|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|positive regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transport|
|positive regulation of ion transmembrane transport|
|positive regulation of transmembrane transport|
|regulation of calcium ion transport|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cellular homeostasis|
|regulation of cellular localization|
|positive regulation of transport|
|chemical homeostasis|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|homeostatic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.09|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.13|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.31|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.49|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.5|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.58|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|3.18|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|3.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14375
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPSR1 Expression in NALM6 Cells: -2.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>