======= NPTN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPTN
  * **<color #00a2e8>Official Name</color>**: neuroplastin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27020|27020]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y639|Q9Y639]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPTN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPTN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612820|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|ig|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission|
|type 1 fibroblast growth factor receptor binding|
|positive regulation of long-term neuronal synaptic plasticity|
|positive regulation of fibroblast growth factor receptor signaling pathway|
|trans-synaptic signaling by trans-synaptic complex|
|trans-synaptic signaling, modulating synaptic transmission|
|excitatory synapse assembly|
|inhibitory synapse|
|integral component of presynaptic active zone membrane|
|dendrite self-avoidance|
|regulation of receptor localization to synapse|
|cell-cell adhesion mediator activity|
|positive regulation of long-term synaptic potentiation|
|regulation of protein localization to synapse|
|regulation of long-term neuronal synaptic plasticity|
|regulation of fibroblast growth factor receptor signaling pathway|
|immunological synapse|
|regulation of long-term synaptic potentiation|
|long-term synaptic potentiation|
|visual learning|
|neuron recognition|
|integral component of postsynaptic density membrane|
|regulation of neuronal synaptic plasticity|
|visual behavior|
|cell adhesion molecule binding|
|GABA-ergic synapse|
|presynaptic membrane|
|associative learning|
|Schaffer collateral - CA1 synapse|
|synapse assembly|
|ion channel binding|
|learning|
|positive regulation of synaptic transmission|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|regulation of synaptic plasticity|
|positive regulation of ERK1 and ERK2 cascade|
|cell recognition|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|learning or memory|
|axon guidance|
|neuron projection guidance|
|synapse organization|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cytokine production|
|positive regulation of neuron projection development|
|positive regulation of cytosolic calcium ion concentration|
|regulation of ERK1 and ERK2 cascade|
|axon|
|cognition|
|response to light stimulus|
|positive regulation of cellular protein localization|
|regulation of cytosolic calcium ion concentration|
|glutamatergic synapse|
|positive regulation of neuron differentiation|
|axonogenesis|
|positive regulation of cell projection organization|
|axon development|
|dendrite|
|cell morphogenesis involved in neuron differentiation|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|divalent inorganic cation homeostasis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell-cell adhesion|
|cell part morphogenesis|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|cellular metal ion homeostasis|
|cell morphogenesis involved in differentiation|
|behavior|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of cytokine production|
|regulation of plasma membrane bounded cell projection organization|
|cation homeostasis|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|cell morphogenesis|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|ion homeostasis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|cellular homeostasis|
|regulation of cellular localization|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|positive regulation of cell differentiation|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|chemical homeostasis|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|locomotion|
|positive regulation of developmental process|
|nervous system process|
|regulation of protein phosphorylation|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.51|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.34|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-2.22|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.12|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.09|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-2.07|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-1.98|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.85|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.84|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.83|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.94|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|3.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12443
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPTN Expression in NALM6 Cells: 5.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>