======= NPY =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPY
  * **<color #00a2e8>Official Name</color>**: neuropeptide Y
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4852|4852]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01303|P01303]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPY&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPY|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/162640|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hormone 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuropeptide Y receptor binding|
|positive regulation of appetite|
|positive regulation of response to food|
|positive regulation of response to extracellular stimulus|
|positive regulation of response to nutrient levels|
|adult feeding behavior|
|regulation of response to food|
|intestinal epithelial cell differentiation|
|regulation of appetite|
|regulation of response to extracellular stimulus|
|regulation of response to nutrient levels|
|neuropeptide hormone activity|
|calcium channel regulator activity|
|G protein-coupled receptor binding|
|central nervous system neuron development|
|cell|
|feeding behavior|
|columnar/cuboidal epithelial cell differentiation|
|neuropeptide signaling pathway|
|cerebral cortex development|
|digestive tract development|
|digestive system development|
|adult behavior|
|pallium development|
|central nervous system neuron differentiation|
|regulation of blood pressure|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|telencephalon development|
|signaling receptor binding|
|forebrain development|
|blood circulation|
|circulatory system process|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|synaptic signaling|
|response to nutrient levels|
|response to extracellular stimulus|
|behavior|
|positive regulation of response to external stimulus|
|neuron projection development|
|epithelial cell differentiation|
|G protein-coupled receptor activity|
|brain development|
|head development|
|neuron development|
|tube development|
|central nervous system development|
|Golgi apparatus|
|neuron differentiation|
|regulation of response to external stimulus|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|G protein-coupled receptor signaling pathway|
|generation of neurons|
|extracellular space|
|neurogenesis|
|cell development|
|tissue development|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.82|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.85|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.96|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.96|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.61|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5493
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPY Expression in NALM6 Cells: 2.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>