======= NR1H3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NR1H3
  * **<color #00a2e8>Official Name</color>**: nuclear receptor subfamily 1 group H member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10062|10062]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13133|Q13133]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NR1H3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NR1H3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602423|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). {ECO:0000250|UniProtKB:Q9Z0Y9, ECO:0000269|PubMed:25661920}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C4|
|Hormone recep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of secretion of lysosomal enzymes|
|negative regulation of secretion of lysosomal enzymes|
|sterol response element binding|
|regulation of nuclear receptor transcription coactivator activity|
|negative regulation of pinocytosis|
|negative regulation of pancreatic juice secretion|
|regulation of pancreatic juice secretion|
|negative regulation of interferon-gamma-mediated signaling pathway|
|negative regulation of response to interferon-gamma|
|negative regulation of cholesterol storage|
|positive regulation of lipoprotein lipase activity|
|positive regulation of toll-like receptor 4 signaling pathway|
|positive regulation of triglyceride lipase activity|
|regulation of pinocytosis|
|positive regulation of triglyceride biosynthetic process|
|positive regulation of receptor biosynthetic process|
|negative regulation of macrophage derived foam cell differentiation|
|regulation of cholesterol storage|
|positive regulation of cholesterol efflux|
|negative regulation of macrophage activation|
|regulation of triglyceride biosynthetic process|
|positive regulation of fatty acid biosynthetic process|
|negative regulation of digestive system process|
|negative regulation of lipid storage|
|positive regulation of triglyceride metabolic process|
|regulation of lipoprotein lipase activity|
|regulation of toll-like receptor 4 signaling pathway|
|regulation of receptor biosynthetic process|
|positive regulation of sterol transport|
|positive regulation of cholesterol transport|
|regulation of cholesterol efflux|
|positive regulation of toll-like receptor signaling pathway|
|regulation of response to interferon-gamma|
|regulation of interferon-gamma-mediated signaling pathway|
|negative regulation of lipid transport|
|regulation of macrophage derived foam cell differentiation|
|positive regulation of fatty acid metabolic process|
|acylglycerol homeostasis|
|triglyceride homeostasis|
|regulation of triglyceride metabolic process|
|apoptotic cell clearance|
|regulation of digestive system process|
|negative regulation of lipid localization|
|negative regulation of endocytosis|
|regulation of lipid storage|
|regulation of cholesterol transport|
|regulation of fatty acid biosynthetic process|
|response to progesterone|
|regulation of sterol transport|
|negative regulation of cold-induced thermogenesis|
|nuclear receptor activity|
|cholesterol binding|
|regulation of macrophage activation|
|steroid hormone receptor activity|
|negative regulation of innate immune response|
|negative regulation of cytokine-mediated signaling pathway|
|positive regulation of lipid transport|
|negative regulation of response to cytokine stimulus|
|nuclear receptor transcription coactivator activity|
|regulation of toll-like receptor signaling pathway|
|positive regulation of lipase activity|
|RNA polymerase II transcription factor complex|
|transcription regulatory region sequence-specific DNA binding|
|positive regulation of lipid biosynthetic process|
|cholesterol homeostasis|
|sterol homeostasis|
|positive regulation of lipid localization|
|regulation of fatty acid metabolic process|
|negative regulation of response to biotic stimulus|
|regulation of lipase activity|
|regulation of lipid transport|
|regulation of circadian rhythm|
|steroid hormone mediated signaling pathway|
|negative regulation of protein secretion|
|lipid homeostasis|
|negative regulation of inflammatory response|
|positive regulation of small molecule metabolic process|
|regulation of lipid localization|
|negative regulation of peptide secretion|
|positive regulation of lipid metabolic process|
|regulation of cold-induced thermogenesis|
|negative regulation of immune response|
|regulation of cytokine-mediated signaling pathway|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|regulation of cellular ketone metabolic process|
|negative regulation of leukocyte activation|
|transcription initiation from RNA polymerase II promoter|
|regulation of response to cytokine stimulus|
|negative regulation of protein transport|
|cellular response to lipopolysaccharide|
|negative regulation of establishment of protein localization|
|regulation of lipid biosynthetic process|
|cellular response to steroid hormone stimulus|
|cellular response to molecule of bacterial origin|
|response to ketone|
|negative regulation of cell activation|
|negative regulation of secretion by cell|
|signaling receptor activity|
|receptor complex|
|regulation of endocytosis|
|negative regulation of defense response|
|cellular response to biotic stimulus|
|negative regulation of multi-organism process|
|DNA-templated transcription, initiation|
|transcription regulatory region DNA binding|
|negative regulation of secretion|
|nuclear chromatin|
|transcription coactivator activity|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|response to steroid hormone|
|phagocytosis|
|transcription factor binding|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|negative regulation of response to external stimulus|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|negative regulation of immune system process|
|regulation of innate immune response|
|regulation of protein secretion|
|positive regulation of defense response|
|transcription by RNA polymerase II|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of body fluid levels|
|positive regulation of multi-organism process|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|cellular response to organic cyclic compound|
|regulation of vesicle-mediated transport|
|regulation of system process|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|regulation of cell activation|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|response to bacterium|
|negative regulation of cellular component organization|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|regulation of secretion|
|zinc ion binding|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|response to hormone|
|response to organic cyclic compound|
|negative regulation of developmental process|
|positive regulation of transport|
|response to drug|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|positive regulation of immune system process|
|regulation of immune response|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15793
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NR1H3 Expression in NALM6 Cells: 2.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>