======= NR2E1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NR2E1
  * **<color #00a2e8>Official Name</color>**: nuclear receptor subfamily 2 group E member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7101|7101]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y466|Q9Y466]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NR2E1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NR2E1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603849|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an orphan receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hormone recep|
|zf-C4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of timing of neuron differentiation|
|amygdala development|
|anterior commissure morphogenesis|
|aggressive behavior|
|layer formation in cerebral cortex|
|negative regulation of astrocyte differentiation|
|regulation of timing of cell differentiation|
|regulation of development, heterochronic|
|dentate gyrus development|
|telencephalon glial cell migration|
|cerebral cortex radial glia guided migration|
|negative regulation of neural precursor cell proliferation|
|cerebral cortex neuron differentiation|
|central nervous system projection neuron axonogenesis|
|negative regulation of glial cell differentiation|
|regulation of astrocyte differentiation|
|cerebral cortex radially oriented cell migration|
|behavioral fear response|
|behavioral defense response|
|olfactory bulb development|
|olfactory lobe development|
|fear response|
|central nervous system neuron axonogenesis|
|glial cell migration|
|regulation of cell migration involved in sprouting angiogenesis|
|positive regulation of stem cell proliferation|
|negative regulation of gliogenesis|
|cerebral cortex cell migration|
|long-term synaptic potentiation|
|social behavior|
|intraspecies interaction between organisms|
|steroid hormone receptor activity|
|positive regulation of neural precursor cell proliferation|
|telencephalon cell migration|
|forebrain cell migration|
|regulation of stem cell proliferation|
|somatic stem cell population maintenance|
|forebrain generation of neurons|
|multi-organism behavior|
|multicellular organismal response to stress|
|regulation of sprouting angiogenesis|
|regulation of glial cell differentiation|
|central nervous system neuron development|
|hippocampus development|
|regulation of neural precursor cell proliferation|
|regulation of blood vessel endothelial cell migration|
|regulation of dendrite morphogenesis|
|limbic system development|
|histone deacetylase binding|
|regulation of gliogenesis|
|cerebral cortex development|
|steroid hormone mediated signaling pathway|
|stem cell population maintenance|
|maintenance of cell number|
|retina development in camera-type eye|
|regulation of dendrite development|
|positive regulation of synaptic transmission|
|regulation of endothelial cell migration|
|positive regulation of angiogenesis|
|hormone-mediated signaling pathway|
|pallium development|
|transcription initiation from RNA polymerase II promoter|
|central nervous system neuron differentiation|
|positive regulation of vasculature development|
|cellular response to steroid hormone stimulus|
|regulation of synaptic plasticity|
|gliogenesis|
|DNA-templated transcription, initiation|
|regulation of epithelial cell migration|
|visual perception|
|sensory perception of light stimulus|
|negative regulation of neuron differentiation|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|cell fate commitment|
|telencephalon development|
|regulation of angiogenesis|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|camera-type eye development|
|regulation of vasculature development|
|response to steroid hormone|
|negative regulation of cell development|
|extracellular matrix organization|
|eye development|
|visual system development|
|sensory system development|
|axonogenesis|
|positive regulation of cell cycle|
|extracellular structure organization|
|forebrain development|
|axon development|
|sequence-specific DNA binding|
|cell morphogenesis involved in neuron differentiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|neuron projection morphogenesis|
|transcription by RNA polymerase II|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell part morphogenesis|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|sensory organ development|
|cell morphogenesis involved in differentiation|
|behavior|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of neuron differentiation|
|neuron projection development|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|zinc ion binding|
|regulation of cell migration|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cell migration|
|sensory perception|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|nucleobase-containing compound biosynthetic process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|defense response|
|positive regulation of developmental process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9036
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NR2E1 Expression in NALM6 Cells: -0.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>