======= NRD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NRDC
  * **<color #00a2e8>Official Name</color>**: nardilysin convertase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4898|4898]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43847|O43847]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NRD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NRD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602651|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M16|
|Peptidase M16 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|epidermal growth factor binding|
|positive regulation of membrane protein ectodomain proteolysis|
|regulation of membrane protein ectodomain proteolysis|
|neuromuscular junction development|
|negative regulation of cold-induced thermogenesis|
|metalloendopeptidase activity|
|regulation of cold-induced thermogenesis|
|positive regulation of protein catabolic process|
|synapse organization|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|regulation of endopeptidase activity|
|positive regulation of catabolic process|
|regulation of peptidase activity|
|cell population proliferation|
|cell surface|
|regulation of proteolysis|
|regulation of cellular catabolic process|
|cell migration|
|regulation of catabolic process|
|cell motility|
|localization of cell|
|negative regulation of multicellular organismal process|
|mitochondrion|
|proteolysis|
|regulation of hydrolase activity|
|locomotion|
|movement of cell or subcellular component|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.71|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pdap1|PDAP1]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5979
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NRD1 Expression in NALM6 Cells: 7.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>