======= NRG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NRG1
  * **<color #00a2e8>Official Name</color>**: neuregulin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3084|3084]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02297|Q02297]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NRG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NRG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142445|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-set|
|ig|
|I-set|
|Neuregulin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|directional guidance of interneurons involved in migration from the subpallium to the cortex|
|chemorepulsion involved in interneuron migration from the subpallium to the cortex|
|ERBB3 signaling pathway|
|neurotransmitter receptor metabolic process|
|ErbB-3 class receptor binding|
|ErbB-2 class receptor binding|
|transmembrane receptor protein tyrosine kinase activator activity|
|regulation of protein heterodimerization activity|
|endocardial cell differentiation|
|cardiac endothelial cell differentiation|
|interneuron migration from the subpallium to the cortex|
|postsynapse to nucleus signaling pathway|
|protein tyrosine kinase activator activity|
|cardiac muscle cell myoblast differentiation|
|substrate-independent telencephalic tangential interneuron migration|
|substrate-independent telencephalic tangential migration|
|cardiac conduction system development|
|negative regulation of neuron migration|
|activation of transmembrane receptor protein tyrosine kinase activity|
|cardioblast differentiation|
|endocardium development|
|glial cell fate commitment|
|ventricular trabecula myocardium morphogenesis|
|positive regulation of calcineurin-mediated signaling|
|positive regulation of calcineurin-NFAT signaling cascade|
|positive regulation of cardiac muscle cell differentiation|
|regulation of protein homodimerization activity|
|myelination in peripheral nervous system|
|peripheral nervous system axon ensheathment|
|chemorepellent activity|
|positive regulation of cardiocyte differentiation|
|Schwann cell development|
|heart trabecula morphogenesis|
|activation of protein kinase B activity|
|ERBB2 signaling pathway|
|regulation of calcineurin-NFAT signaling cascade|
|regulation of calcineurin-mediated signaling|
|myoblast differentiation|
|Schwann cell differentiation|
|regulation of cardiac muscle cell differentiation|
|postsynaptic signal transduction|
|regulation of neuron migration|
|positive regulation of calcium-mediated signaling|
|positive regulation of cardiac muscle tissue development|
|negative chemotaxis|
|trabecula morphogenesis|
|ventricular cardiac muscle tissue morphogenesis|
|regulation of cardiocyte differentiation|
|ventricular cardiac muscle tissue development|
|positive regulation of protein tyrosine kinase activity|
|receptor tyrosine kinase binding|
|telencephalon cell migration|
|positive regulation of striated muscle cell differentiation|
|forebrain cell migration|
|positive regulation of Ras protein signal transduction|
|neuron fate commitment|
|GABA-ergic synapse|
|cardiac muscle tissue morphogenesis|
|oligodendrocyte differentiation|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle organ development|
|positive regulation of muscle tissue development|
|ERBB signaling pathway|
|positive regulation of small GTPase mediated signal transduction|
|cardiac ventricle morphogenesis|
|peripheral nervous system development|
|neuromuscular junction|
|regulation of cardiac muscle tissue development|
|neural crest cell development|
|muscle tissue morphogenesis|
|endothelial cell differentiation|
|transcription coregulator activity|
|mesenchymal cell development|
|stem cell development|
|positive regulation of muscle cell differentiation|
|muscle organ morphogenesis|
|cardiac muscle cell differentiation|
|neural crest cell differentiation|
|regulation of protein tyrosine kinase activity|
|synapse assembly|
|endothelium development|
|regulation of calcium-mediated signaling|
|regulation of striated muscle cell differentiation|
|receptor metabolic process|
|myelination|
|glial cell development|
|ensheathment of neurons|
|axon ensheathment|
|cardiocyte differentiation|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|mammary gland development|
|integrin binding|
|regulation of striated muscle tissue development|
|negative regulation of protein catabolic process|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|regulation of muscle cell differentiation|
|activation of MAPK activity|
|mesenchymal cell differentiation|
|stem cell differentiation|
|cardiac muscle tissue development|
|growth factor activity|
|positive regulation of protein kinase B signaling|
|glial cell differentiation|
|cardiac chamber development|
|cytokine activity|
|positive regulation of peptidyl-tyrosine phosphorylation|
|locomotory behavior|
|striated muscle cell differentiation|
|gliogenesis|
|regulation of protein binding|
|regulation of protein kinase B signaling|
|mesenchyme development|
|negative regulation of secretion|
|regulation of Ras protein signal transduction|
|muscle cell differentiation|
|cell fate commitment|
|heart morphogenesis|
|regulation of peptidyl-tyrosine phosphorylation|
|telencephalon development|
|negative regulation of cell migration|
|positive regulation of MAP kinase activity|
|synapse organization|
|negative regulation of cell motility|
|striated muscle tissue development|
|negative regulation of neurogenesis|
|muscle organ development|
|axon|
|muscle tissue development|
|negative regulation of cellular component movement|
|negative regulation of catabolic process|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|activation of protein kinase activity|
|negative regulation of cell development|
|signaling receptor binding|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of small GTPase mediated signal transduction|
|glutamatergic synapse|
|MAPK cascade|
|regulation of binding|
|regulation of protein catabolic process|
|forebrain development|
|signal transduction by protein phosphorylation|
|gland development|
|synaptic signaling|
|muscle structure development|
|wound healing|
|negative regulation of transport|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|heart development|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|tissue morphogenesis|
|response to wounding|
|behavior|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|epithelial cell differentiation|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|brain development|
|regulation of MAPK cascade|
|head development|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of neurogenesis|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|regulation of cell migration|
|circulatory system development|
|regulation of kinase activity|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|regulation of catabolic process|
|regulation of cellular component movement|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|negative regulation of protein metabolic process|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|phosphorylation|
|locomotion|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|extracellular region|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18451
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NRG1 Expression in NALM6 Cells: -2.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>