======= NSA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NSA2
  * **<color #00a2e8>Official Name</color>**: NSA2 ribosome biogenesis factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10412|10412]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95478|O95478]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NSA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NSA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612497|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S8e|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|preribosome, large subunit precursor|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.26|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.74|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.87|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.92|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.96|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|2.12|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|2.43|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.53|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 434/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|17/28|
|blood|19/28|
|bone|18/26|
|breast|22/33|
|central nervous system|40/56|
|cervix|3/4|
|colorectal|10/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|14/16|
|kidney|13/21|
|liver|10/20|
|lung|45/75|
|lymphocyte|10/16|
|ovary|16/26|
|pancreas|10/24|
|peripheral nervous system|10/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|9/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|15/22|
|urinary tract|16/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 283
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NSA2 Expression in NALM6 Cells: 6.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>