======= NSFL1C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NSFL1C
  * **<color #00a2e8>Official Name</color>**: NSFL1 cofactor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55968|55968]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UNZ2|Q9UNZ2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NSFL1C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NSFL1C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606610|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UBX|
|SEP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|VCP-NSFL1C complex|
|negative regulation of protein localization to centrosome|
|positive regulation of mitotic centrosome separation|
|regulation of mitotic centrosome separation|
|regulation of protein localization to centrosome|
|positive regulation of centrosome cycle|
|spindle pole centrosome|
|nuclear envelope reassembly|
|establishment of mitotic spindle orientation|
|establishment of mitotic spindle localization|
|establishment of spindle orientation|
|Golgi stack|
|establishment of spindle localization|
|intermediate filament cytoskeleton|
|spindle localization|
|positive regulation of mitotic nuclear division|
|nuclear envelope organization|
|regulation of centrosome cycle|
|autophagosome assembly|
|autophagosome organization|
|positive regulation of nuclear division|
|ubiquitin binding|
|ATPase binding|
|microtubule cytoskeleton organization involved in mitosis|
|phospholipid binding|
|negative regulation of cellular protein localization|
|establishment of cell polarity|
|chromosome|
|vacuole organization|
|membrane fusion|
|Golgi organization|
|nucleus organization|
|positive regulation of mitotic cell cycle|
|macroautophagy|
|regulation of mitotic nuclear division|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|establishment or maintenance of cell polarity|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|autophagy|
|process utilizing autophagic mechanism|
|positive regulation of cell cycle process|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|establishment of organelle localization|
|positive regulation of cell cycle|
|endomembrane system organization|
|microtubule cytoskeleton organization|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|modification-dependent macromolecule catabolic process|
|organelle localization|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|protein catabolic process|
|regulation of cell cycle process|
|organelle assembly|
|membrane organization|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|cell cycle process|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cytoskeleton organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-3.06|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.55|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-2.37|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.3|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-2.27|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.21|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-2.11|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.85|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.84|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.75|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.74|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.7|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.73|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.75|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|1.75|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.93|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.08|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17703
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NSFL1C Expression in NALM6 Cells: 5.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>