======= NSL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NSL1
  * **<color #00a2e8>Official Name</color>**: NSL1 component of MIS12 kinetochore complex
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25936|25936]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96IY1|Q96IY1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NSL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NSL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609174|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:16585270}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mis14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|MIS12/MIND type complex|
|condensed chromosome kinetochore|
|mitotic sister chromatid segregation|
|sister chromatid segregation|
|mitotic nuclear division|
|nuclear chromosome segregation|
|chromosome segregation|
|nuclear division|
|organelle fission|
|nuclear speck|
|cell division|
|mitotic cell cycle process|
|mitotic cell cycle|
|cell cycle process|
|chromosome organization|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.91|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.33|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.3|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.17|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.09|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.07|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.96|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.77|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.82|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 21/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|1/25|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|1/21|
|liver|0/20|
|lung|4/75|
|lymphocyte|2/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|2/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1807
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NSL1 Expression in NALM6 Cells: 4.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>