======= NTRK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NTRK2
  * **<color #00a2e8>Official Name</color>**: neurotrophic receptor tyrosine kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4915|4915]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16620|Q16620]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NTRK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NTRK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600456|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin- 4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin- dependent calcium signaling in glial cells and mediate communication between neurons and glia. {ECO:0000269|PubMed:15494731}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|Pkinase Tyr|
|LRRNT|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|trans-synaptic signaling by neuropeptide|
|brain-derived neurotrophic factor-activated receptor activity|
|trans-synaptic signaling by neuropeptide, modulating synaptic transmission|
|synaptic signaling via neuropeptide|
|trans-synaptic signaling by BDNF, modulating synaptic transmission|
|neurotrophin receptor activity|
|trans-synaptic signaling by BDNF|
|brain-derived neurotrophic factor binding|
|neurotrophin binding|
|brain-derived neurotrophic factor receptor signaling pathway|
|positive regulation of non-membrane spanning protein tyrosine kinase activity|
|regulation of non-membrane spanning protein tyrosine kinase activity|
|retinal rod cell development|
|neuronal action potential propagation|
|action potential propagation|
|cellular response to brain-derived neurotrophic factor stimulus|
|trans-synaptic signaling, modulating synaptic transmission|
|peripheral nervous system neuron differentiation|
|peripheral nervous system neuron development|
|negative regulation of anoikis|
|neurotrophin TRK receptor signaling pathway|
|regulation of anoikis|
|peripheral nervous system axon ensheathment|
|myelination in peripheral nervous system|
|neurotrophin signaling pathway|
|Schwann cell development|
|glutamate secretion|
|activation of phospholipase C activity|
|eye photoreceptor cell development|
|Schwann cell differentiation|
|positive regulation of phospholipase C activity|
|eye photoreceptor cell differentiation|
|regulation of phospholipase C activity|
|photoreceptor cell development|
|acidic amino acid transport|
|long-term synaptic potentiation|
|terminal bouton|
|cellular response to nerve growth factor stimulus|
|axon terminus|
|response to nerve growth factor|
|positive regulation of protein tyrosine kinase activity|
|transmission of nerve impulse|
|transmembrane receptor protein tyrosine kinase activity|
|mechanoreceptor differentiation|
|photoreceptor cell differentiation|
|positive regulation of phospholipase activity|
|positive regulation of synapse assembly|
|vasculogenesis|
|cellular response to amino acid stimulus|
|oligodendrocyte differentiation|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|peripheral nervous system development|
|dicarboxylic acid transport|
|central nervous system neuron development|
|acid secretion|
|positive regulation of axonogenesis|
|feeding behavior|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|protein tyrosine kinase activity|
|regulation of protein tyrosine kinase activity|
|action potential|
|regulation of lipase activity|
|regulation of synapse assembly|
|positive regulation of peptidyl-serine phosphorylation|
|myelination|
|glial cell development|
|axon ensheathment|
|ensheathment of neurons|
|response to amino acid|
|cerebral cortex development|
|amino acid transport|
|regulation of phosphatidylinositol 3-kinase signaling|
|neuron migration|
|multicellular organismal signaling|
|regulation of peptidyl-serine phosphorylation|
|retina development in camera-type eye|
|circadian rhythm|
|peptidyl-tyrosine phosphorylation|
|negative regulation of neuron apoptotic process|
|learning|
|eye morphogenesis|
|peptidyl-tyrosine modification|
|dendritic spine|
|positive regulation of synaptic transmission|
|early endosome membrane|
|positive regulation of cell morphogenesis involved in differentiation|
|glial cell differentiation|
|pallium development|
|central nervous system neuron differentiation|
|regulation of axonogenesis|
|regulation of synaptic plasticity|
|positive regulation of peptidyl-tyrosine phosphorylation|
|protein autophosphorylation|
|receptor complex|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|cellular response to acid chemical|
|positive regulation of ERK1 and ERK2 cascade|
|gliogenesis|
|regulation of synapse organization|
|regulation of protein kinase B signaling|
|regulation of synapse structure or activity|
|regulation of peptidyl-tyrosine phosphorylation|
|postsynaptic density|
|early endosome|
|sensory organ morphogenesis|
|telencephalon development|
|learning or memory|
|rhythmic process|
|positive regulation of neuron projection development|
|carboxylic acid transport|
|organic acid transport|
|regulation of ERK1 and ERK2 cascade|
|axon|
|cognition|
|regulation of cell morphogenesis involved in differentiation|
|regulation of neuron death|
|camera-type eye development|
|response to acid chemical|
|eye development|
|visual system development|
|sensory system development|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|forebrain development|
|blood vessel morphogenesis|
|dendrite|
|regulation of membrane potential|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|positive regulation of neurogenesis|
|regulation of GTPase activity|
|blood vessel development|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|sensory organ development|
|behavior|
|positive regulation of kinase activity|
|anion transport|
|cellular response to organonitrogen compound|
|Golgi membrane|
|tube morphogenesis|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|brain development|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|head development|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|tube development|
|circulatory system development|
|regulation of kinase activity|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|central nervous system development|
|negative regulation of cell death|
|response to organonitrogen compound|
|secretion by cell|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|cell-cell signaling|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|locomotion|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|nitrogen compound transport|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10992
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NTRK2 Expression in NALM6 Cells: -0.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>