======= NUDT16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUDT16
  * **<color #00a2e8>Official Name</color>**: nudix hydrolase 16
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=131870|131870]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96DE0|Q96DE0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUDT16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUDT16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617381|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal- dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms (PubMed:20385596, PubMed:26121039). The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP (PubMed:20385596). Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions (PubMed:20385596). {ECO:0000269|PubMed:15053875, ECO:0000269|PubMed:17567574, ECO:0000269|PubMed:18820299, ECO:0000269|PubMed:20385596, ECO:0000269|PubMed:21070968, ECO:0000269|PubMed:21337011, ECO:0000269|PubMed:26121039}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NUDIX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|XTP binding|
|XDP catabolic process|
|dITP metabolic process|
|ITP binding|
|dITP catabolic process|
|IDP metabolic process|
|dITP diphosphatase activity|
|negative regulation of rRNA processing|
|IDP catabolic process|
|snoRNA catabolic process|
|cobalt ion binding|
|phosphodiesterase decapping endonuclease activity|
|purine ribonucleoside diphosphate catabolic process|
|negative regulation of ribosome biogenesis|
|purine nucleoside diphosphate catabolic process|
|nucleotide phosphatase activity, acting on free nucleotides|
|purine deoxyribonucleoside triphosphate catabolic process|
|purine deoxyribonucleotide catabolic process|
|purine nucleoside triphosphate catabolic process|
|ribonucleoside diphosphate catabolic process|
|nucleoside diphosphate catabolic process|
|purine deoxyribonucleoside triphosphate metabolic process|
|deoxyribonucleoside triphosphate catabolic process|
|adenosine to inosine editing|
|m7G(5)pppN diphosphatase activity|
|purine deoxyribonucleotide metabolic process|
|metalloexopeptidase activity|
|regulation of rRNA processing|
|nucleoside triphosphate catabolic process|
|chloride ion binding|
|regulation of ribosome biogenesis|
|snoRNA binding|
|snoRNA metabolic process|
|deoxyribonucleoside triphosphate metabolic process|
|deoxyribonucleotide catabolic process|
|deoxyribose phosphate catabolic process|
|base conversion or substitution editing|
|ncRNA catabolic process|
|positive regulation of double-strand break repair|
|2-deoxyribonucleotide metabolic process|
|purine ribonucleotide catabolic process|
|deoxyribose phosphate metabolic process|
|ribonucleotide catabolic process|
|deoxyribonucleotide metabolic process|
|purine nucleotide catabolic process|
|nucleobase-containing small molecule catabolic process|
|purine-containing compound catabolic process|
|purine nucleoside diphosphate metabolic process|
|manganese ion binding|
|purine ribonucleoside diphosphate metabolic process|
|ribonucleoside diphosphate metabolic process|
|nucleotide catabolic process|
|positive regulation of DNA repair|
|purine nucleoside triphosphate metabolic process|
|nucleoside phosphate catabolic process|
|regulation of double-strand break repair|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|nucleoside diphosphate metabolic process|
|nucleoside triphosphate metabolic process|
|positive regulation of response to DNA damage stimulus|
|nucleobase-containing small molecule biosynthetic process|
|regulation of DNA repair|
|organophosphate catabolic process|
|RNA phosphodiester bond hydrolysis|
|mRNA binding|
|RNA modification|
|carbohydrate derivative catabolic process|
|positive regulation of DNA metabolic process|
|magnesium ion binding|
|mRNA catabolic process|
|regulation of response to DNA damage stimulus|
|RNA catabolic process|
|positive regulation of cell cycle process|
|nucleic acid phosphodiester bond hydrolysis|
|dephosphorylation|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|regulation of DNA metabolic process|
|purine-containing compound metabolic process|
|nucleobase-containing compound catabolic process|
|positive regulation of cell cycle|
|GTP binding|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|mRNA metabolic process|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|nucleolus|
|protein homodimerization activity|
|organophosphate metabolic process|
|cellular macromolecule catabolic process|
|positive regulation of cell population proliferation|
|regulation of cellular component biogenesis|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|proteolysis|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of response to stress|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|negative regulation of gene expression|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8989
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUDT16 Expression in NALM6 Cells: 3.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>