======= NUFIP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUFIP2
  * **<color #00a2e8>Official Name</color>**: nuclear FMR1 interacting protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57532|57532]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z417|Q7Z417]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUFIP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUFIP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609356|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds RNA. {ECO:0000269|PubMed:12837692}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|polysomal ribosome|
|cytoplasmic stress granule|
|nuclear body|
|RNA binding|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.76|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.74|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.71|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.72|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|1.86|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.86|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.9|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.93|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|2.16|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.17|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.27|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.514|
|[[:human genes:c:ccna2|CCNA2]]|0.476|
|[[:human genes:t:tfip11|TFIP11]]|0.466|
|[[:human genes:z:znf148|ZNF148]]|0.465|
|[[:human genes:c:cdc73|CDC73]]|0.462|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.458|
|[[:human genes:t:tceb3c|TCEB3C]]|0.453|
|[[:human genes:s:sf3a3|SF3A3]]|0.447|
|[[:human genes:a:akirin2|AKIRIN2]]|0.446|
|[[:human genes:a:ankle2|ANKLE2]]|0.446|
|[[:human genes:s:snrpa1|SNRPA1]]|0.445|
|[[:human genes:c:cwc22|CWC22]]|0.442|
|[[:human genes:i:iscu|ISCU]]|0.442|
|[[:human genes:c:copg1|COPG1]]|0.441|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.438|
|[[:human genes:k:kctd17|KCTD17]]|0.437|
|[[:human genes:s:sec13|SEC13]]|0.436|
|[[:human genes:c:cyb561a3|CYB561A3]]|0.432|
|[[:human genes:t:ticrr|TICRR]]|0.432|
|[[:human genes:u:ube2e1|UBE2E1]]|0.43|
|[[:human genes:v:vasn|VASN]]|0.425|
|[[:human genes:c:chaf1a|CHAF1A]]|0.424|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.422|
|[[:human genes:n:ndc1|NDC1]]|0.421|
|[[:human genes:v:vps54|VPS54]]|0.421|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.419|
|[[:human genes:o:orc1|ORC1]]|0.417|
|[[:human genes:n:narfl|NARFL]]|0.416|
|[[:human genes:c:cdc6|CDC6]]|0.416|
|[[:human genes:c:crnkl1|CRNKL1]]|0.413|
|[[:human genes:p:psmb4|PSMB4]]|0.411|
|[[:human genes:s:snrnp70|SNRNP70]]|0.411|
|[[:human genes:n:napa|NAPA]]|0.41|
|[[:human genes:n:nup160|NUP160]]|0.41|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.41|
|[[:human genes:d:dtl|DTL]]|0.408|
|[[:human genes:c:chd4|CHD4]]|0.407|
|[[:human genes:w:wdr75|WDR75]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1124
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUFIP2 Expression in NALM6 Cells: 8.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>