======= NUP160 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUP160
  * **<color #00a2e8>Official Name</color>**: nucleoporin 160
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23279|23279]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12769|Q12769]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUP160&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUP160|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607614|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in poly(A)+ RNA transport. {ECO:0000269|PubMed:11684705}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nup160|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear pore outer ring|
|structural constituent of nuclear pore|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|intracellular transport of virus|
|host cell|
|transport of virus|
|protein sumoylation|
|multi-organism localization|
|multi-organism transport|
|nuclear pore|
|regulation of cellular response to heat|
|regulation of glycolytic process|
|kinetochore|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|viral transcription|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|nephron development|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|viral gene expression|
|regulation of gene silencing|
|protein export from nucleus|
|mRNA transport|
|regulation of generation of precursor metabolites and energy|
|nuclear export|
|nuclear envelope|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|kidney development|
|renal system development|
|peptidyl-lysine modification|
|urogenital system development|
|regulation of small molecule metabolic process|
|viral process|
|regulation of cellular response to stress|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|intracellular protein transport|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.57|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.3|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.3|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.97|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.79|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.72|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.7|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.7|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.73|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.76|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.81|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.84|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.85|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.88|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.94|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.96|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.97|
|[[:results:exp303|39°C R06 exp303]]|2.05|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.07|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|2.08|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|2.11|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.11|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|2.18|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.23|
|[[:results:exp114|A-196 10μM R03 exp114]]|2.24|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|2.25|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|2.42|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|2.45|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|2.64|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|2.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb4|PSMB4]]|0.593|
|[[:human genes:c:copg1|COPG1]]|0.559|
|[[:human genes:t:tceb3c|TCEB3C]]|0.551|
|[[:human genes:n:npipb5|NPIPB5]]|0.538|
|[[:human genes:p:prim1|PRIM1]]|0.537|
|[[:human genes:c:cdc73|CDC73]]|0.534|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.529|
|[[:human genes:v:vasn|VASN]]|0.529|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.528|
|[[:human genes:s:slc6a17|SLC6A17]]|0.527|
|[[:human genes:s:supt5h|SUPT5H]]|0.524|
|[[:human genes:t:ticrr|TICRR]]|0.523|
|[[:human genes:d:dtl|DTL]]|0.522|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.511|
|[[:human genes:c:chd4|CHD4]]|0.51|
|[[:human genes:n:nupl1|NUPL1]]|0.509|
|[[:human genes:p:pole|POLE]]|0.507|
|[[:human genes:c:c14orf93|C14orf93]]|0.506|
|[[:human genes:p:psmd14|PSMD14]]|0.502|
|[[:human genes:r:rpl35|RPL35]]|0.5|
|[[:human genes:s:sec13|SEC13]]|0.498|
|[[:human genes:c:cbwd3|CBWD3]]|0.498|
|[[:human genes:c:cbwd5|CBWD5]]|0.494|
|[[:human genes:p:psma6|PSMA6]]|0.494|
|[[:human genes:p:psmd3|PSMD3]]|0.493|
|[[:human genes:l:lrr1|LRR1]]|0.492|
|[[:human genes:p:pola1|POLA1]]|0.491|
|[[:human genes:a:arcn1|ARCN1]]|0.487|
|[[:human genes:n:nfatc4|NFATC4]]|0.485|
|[[:human genes:m:mt1e|MT1E]]|0.482|
|[[:human genes:p:psmb2|PSMB2]]|0.481|
|[[:human genes:p:pwp2|PWP2]]|0.48|
|[[:human genes:c:cbwd6|CBWD6]]|0.479|
|[[:human genes:p:psmc2|PSMC2]]|0.479|
|[[:human genes:n:nup85|NUP85]]|0.478|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.478|
|[[:human genes:c:cdc45|CDC45]]|0.477|
|[[:human genes:r:rrp7a|RRP7A]]|0.475|
|[[:human genes:p:psma7|PSMA7]]|0.473|
|[[:human genes:s:snrpa1|SNRPA1]]|0.472|
|[[:human genes:s:sart1|SART1]]|0.472|
|[[:human genes:r:rbbp5|RBBP5]]|0.471|
|[[:human genes:i:ints5|INTS5]]|0.469|
|[[:human genes:p:psmc5|PSMC5]]|0.469|
|[[:human genes:p:polr2f|POLR2F]]|0.469|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.469|
|[[:human genes:c:copz1|COPZ1]]|0.468|
|[[:human genes:e:eif4a3|EIF4A3]]|0.467|
|[[:human genes:r:rps2|RPS2]]|0.464|
|[[:human genes:u:upf1|UPF1]]|0.464|
|[[:human genes:n:narfl|NARFL]]|0.463|
|[[:human genes:h:hap1|HAP1]]|0.462|
|[[:human genes:c:chaf1a|CHAF1A]]|0.462|
|[[:human genes:c:cgb2|CGB2]]|0.461|
|[[:human genes:r:rad51|RAD51]]|0.461|
|[[:human genes:c:cmya5|CMYA5]]|0.459|
|[[:human genes:r:rbm39|RBM39]]|0.459|
|[[:human genes:a:ahctf1|AHCTF1]]|0.459|
|[[:human genes:z:znf830|ZNF830]]|0.459|
|[[:human genes:v:vps28|VPS28]]|0.456|
|[[:human genes:p:psmd2|PSMD2]]|0.455|
|[[:human genes:c:ccna2|CCNA2]]|0.455|
|[[:human genes:s:sf3a1|SF3A1]]|0.454|
|[[:human genes:p:pan3|PAN3]]|0.454|
|[[:human genes:s:slc4a1|SLC4A1]]|0.453|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.453|
|[[:human genes:a:aqr|AQR]]|0.453|
|[[:human genes:o:orc1|ORC1]]|0.452|
|[[:human genes:c:copb1|COPB1]]|0.451|
|[[:human genes:s:stil|STIL]]|0.45|
|[[:human genes:d:dock6|DOCK6]]|0.449|
|[[:human genes:o:osbp|OSBP]]|0.448|
|[[:human genes:i:ints6|INTS6]]|0.448|
|[[:human genes:t:twistnb|TWISTNB]]|0.448|
|[[:human genes:a:aamp|AAMP]]|0.448|
|[[:human genes:g:gar1|GAR1]]|0.447|
|[[:human genes:l:loc643669|LOC643669]]|0.446|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.444|
|[[:human genes:c:cdc6|CDC6]]|0.444|
|[[:human genes:c:copa|COPA]]|0.443|
|[[:human genes:s:ssh2|SSH2]]|0.443|
|[[:human genes:r:rpsa|RPSA]]|0.443|
|[[:human genes:l:lad1|LAD1]]|0.443|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.442|
|[[:human genes:c:cactin|CACTIN]]|0.442|
|[[:human genes:k:krt78|KRT78]]|0.442|
|[[:human genes:b:brd2|BRD2]]|0.441|
|[[:human genes:d:ddx56|DDX56]]|0.44|
|[[:human genes:t:tfip11|TFIP11]]|0.44|
|[[:human genes:n:ncapg|NCAPG]]|0.44|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.439|
|[[:human genes:i:iscu|ISCU]]|0.439|
|[[:human genes:c:cope|COPE]]|0.439|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.439|
|[[:human genes:a:acsf2|ACSF2]]|0.438|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.437|
|[[:human genes:z:znf655|ZNF655]]|0.436|
|[[:human genes:n:nup205|NUP205]]|0.436|
|[[:human genes:t:tpx2|TPX2]]|0.435|
|[[:human genes:w:wdr75|WDR75]]|0.435|
|[[:human genes:m:med17|MED17]]|0.434|
|[[:human genes:t:tsg101|TSG101]]|0.434|
|[[:human genes:d:dido1|DIDO1]]|0.434|
|[[:human genes:t:tagln|TAGLN]]|0.434|
|[[:human genes:r:riok2|RIOK2]]|0.434|
|[[:human genes:p:plk1|PLK1]]|0.432|
|[[:human genes:s:slc38a7|SLC38A7]]|0.432|
|[[:human genes:b:bod1l1|BOD1L1]]|0.432|
|[[:human genes:c:ckap5|CKAP5]]|0.431|
|[[:human genes:n:nup153|NUP153]]|0.43|
|[[:human genes:p:psmd11|PSMD11]]|0.429|
|[[:human genes:r:rad21|RAD21]]|0.429|
|[[:human genes:e:exosc9|EXOSC9]]|0.429|
|[[:human genes:a:ankle2|ANKLE2]]|0.429|
|[[:human genes:p:paf1|PAF1]]|0.428|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.427|
|[[:human genes:p:psmd1|PSMD1]]|0.427|
|[[:human genes:n:nup155|NUP155]]|0.425|
|[[:human genes:u:ube2q2l|UBE2Q2L]]|0.425|
|[[:human genes:f:fam25b|FAM25B]]|0.425|
|[[:human genes:d:dnm2|DNM2]]|0.425|
|[[:human genes:p:psmb3|PSMB3]]|0.424|
|[[:human genes:r:rfc1|RFC1]]|0.424|
|[[:human genes:p:plrg1|PLRG1]]|0.423|
|[[:human genes:z:znf148|ZNF148]]|0.423|
|[[:human genes:k:kpnb1|KPNB1]]|0.423|
|[[:human genes:e:exosc5|EXOSC5]]|0.421|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.42|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.42|
|[[:human genes:i:ints1|INTS1]]|0.419|
|[[:human genes:f:fam86b2|FAM86B2]]|0.419|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.419|
|[[:human genes:p:polr2j3|POLR2J3]]|0.419|
|[[:human genes:d:ddtl|DDTL]]|0.418|
|[[:human genes:t:tinf2|TINF2]]|0.418|
|[[:human genes:k:kiaa1211|KIAA1211]]|0.416|
|[[:human genes:s:smg1|SMG1]]|0.416|
|[[:human genes:p:pola2|POLA2]]|0.416|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.415|
|[[:human genes:s:sf3a3|SF3A3]]|0.415|
|[[:human genes:t:tyms|TYMS]]|0.415|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.415|
|[[:human genes:a:aldh1b1|ALDH1B1]]|0.413|
|[[:human genes:k:kctd17|KCTD17]]|0.413|
|[[:human genes:t:timeless|TIMELESS]]|0.413|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.412|
|[[:human genes:p:polr2l|POLR2L]]|0.412|
|[[:human genes:f:ftsj3|FTSJ3]]|0.411|
|[[:human genes:p:prpf8|PRPF8]]|0.411|
|[[:human genes:c:chchd3|CHCHD3]]|0.411|
|[[:human genes:e:exosc6|EXOSC6]]|0.411|
|[[:human genes:d:ddx23|DDX23]]|0.411|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.411|
|[[:human genes:p:pigs|PIGS]]|0.41|
|[[:human genes:w:wdr87|WDR87]]|0.41|
|[[:human genes:n:nufip2|NUFIP2]]|0.41|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.41|
|[[:human genes:i:igfn1|IGFN1]]|0.409|
|[[:human genes:g:golga6a|GOLGA6A]]|0.409|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.408|
|[[:human genes:u:usp35|USP35]]|0.407|
|[[:human genes:a:aatf|AATF]]|0.407|
|[[:human genes:a:atp13a1|ATP13A1]]|0.407|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.407|
|[[:human genes:n:npipb15|NPIPB15]]|0.407|
|[[:human genes:r:rpl8|RPL8]]|0.406|
|[[:human genes:n:nckap1l|NCKAP1L]]|0.406|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.406|
|[[:human genes:x:xab2|XAB2]]|0.406|
|[[:human genes:o:orc6|ORC6]]|0.404|
|[[:human genes:r:rffl|RFFL]]|0.404|
|[[:human genes:s:sf3b2|SF3B2]]|0.403|
|[[:human genes:c:cwc22|CWC22]]|0.402|
|[[:human genes:s:snip1|SNIP1]]|0.402|
|[[:human genes:n:nsf|NSF]]|0.402|
|[[:human genes:w:wdr61|WDR61]]|0.401|
|[[:human genes:r:rrn3|RRN3]]|0.401|
|[[:human genes:d:ddx41|DDX41]]|0.401|
|[[:human genes:n:napa|NAPA]]|0.401|
|[[:human genes:j:jund|JUND]]|0.4|
|[[:human genes:p:parp3|PARP3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 203/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|5/28|
|bone|10/26|
|breast|16/33|
|central nervous system|9/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|2/21|
|liver|7/20|
|lung|26/75|
|lymphocyte|5/16|
|ovary|6/26|
|pancreas|9/24|
|peripheral nervous system|6/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|6/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|4/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 954
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUP160 Expression in NALM6 Cells: 8.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>