======= OAS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OAS1
  * **<color #00a2e8>Official Name</color>**: 2'-5'-oligoadenylate synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4938|4938]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00973|P00973]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OAS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OAS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164350|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|OAS1 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|2-5-oligoadenylate synthetase activity|
|regulation of ribonuclease activity|
|regulation of nuclease activity|
|negative regulation of viral genome replication|
|cellular response to type I interferon|
|type I interferon signaling pathway|
|response to type I interferon|
|double-stranded RNA binding|
|interferon-gamma-mediated signaling pathway|
|negative regulation of viral life cycle|
|regulation of viral genome replication|
|negative regulation of viral process|
|glucose metabolic process|
|regulation of viral life cycle|
|hexose metabolic process|
|cellular response to interferon-gamma|
|response to interferon-gamma|
|glucose homeostasis|
|carbohydrate homeostasis|
|defense response to virus|
|monosaccharide metabolic process|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|response to virus|
|carbohydrate metabolic process|
|cytokine-mediated signaling pathway|
|innate immune response|
|regulation of multi-organism process|
|defense response to other organism|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|immune effector process|
|response to cytokine|
|chemical homeostasis|
|mitochondrion|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|ATP binding|
|homeostatic process|
|small molecule metabolic process|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12644
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OAS1 Expression in NALM6 Cells: 2.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>