======= OAZ1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OAZ1
  * **<color #00a2e8>Official Name</color>**: ornithine decarboxylase antizyme 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4946|4946]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54368|P54368]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OAZ1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OAZ1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601579|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240, PubMed:26305948, PubMed:26443277). Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (PubMed:26305948). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:17900240). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:12097147). {ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:17900240, ECO:0000269|PubMed:26305948, ECO:0000269|PubMed:26443277}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of polyamine transmembrane transport|
|ornithine decarboxylase inhibitor activity|
|regulation of polyamine transmembrane transport|
|polyamine biosynthetic process|
|polyamine metabolic process|
|cellular biogenic amine biosynthetic process|
|amine biosynthetic process|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|regulation of cellular amino acid metabolic process|
|amine metabolic process|
|regulation of cellular amine metabolic process|
|negative regulation of transmembrane transport|
|positive regulation of intracellular protein transport|
|regulation of cellular ketone metabolic process|
|positive regulation of intracellular transport|
|positive regulation of protein catabolic process|
|regulation of intracellular protein transport|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|regulation of protein catabolic process|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|positive regulation of establishment of protein localization|
|negative regulation of transport|
|regulation of cellular protein localization|
|regulation of transmembrane transport|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|negative regulation of catalytic activity|
|regulation of cellular localization|
|positive regulation of transport|
|regulation of catabolic process|
|regulation of protein localization|
|negative regulation of molecular function|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of protein metabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.7|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.7|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.74|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.75|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.85|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.85|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.09|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.22|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.37|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.43|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1985
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OAZ1 Expression in NALM6 Cells: 8.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>