======= ODF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ODF2
  * **<color #00a2e8>Official Name</color>**: outer dense fiber of sperm tails 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4957|4957]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5BJF6|Q5BJF6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ODF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ODF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602015|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|outer dense fiber|
|centriolar subdistal appendage|
|ciliary transition fiber|
|centriole-centriole cohesion|
|sperm flagellum|
|centrosome cycle|
|microtubule organizing center organization|
|ciliary basal body-plasma membrane docking|
|spindle pole|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|centriole|
|spermatid development|
|spermatid differentiation|
|organelle localization by membrane tethering|
|membrane docking|
|structural molecule activity|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|germ cell development|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|microtubule|
|cilium assembly|
|cellular process involved in reproduction in multicellular organism|
|cilium organization|
|regulation of mitotic cell cycle phase transition|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|microtubule cytoskeleton organization|
|centrosome|
|spermatogenesis|
|male gamete generation|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|developmental process involved in reproduction|
|microtubule-based process|
|mitotic cell cycle|
|gamete generation|
|regulation of cell cycle process|
|organelle assembly|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|cell cycle process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|cell cycle|
|reproductive process|
|reproduction|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.85|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-1.77|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.36|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|5.23|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|5.57|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|6.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cradd|CRADD]]|0.742|
|[[:human genes:p:pidd|PIDD]]|0.693|
|[[:human genes:p:pibf1|PIBF1]]|0.672|
|[[:human genes:o:ofd1|OFD1]]|0.664|
|[[:human genes:c:c2cd3|C2CD3]]|0.661|
|[[:human genes:c:casp2|CASP2]]|0.66|
|[[:human genes:c:ccdc41|CCDC41]]|0.644|
|[[:human genes:c:cep76|CEP76]]|0.639|
|[[:human genes:c:c14orf80|C14orf80]]|0.633|
|[[:human genes:s:sclt1|SCLT1]]|0.631|
|[[:human genes:c:cep128|CEP128]]|0.627|
|[[:human genes:k:kiaa0753|KIAA0753]]|0.618|
|[[:human genes:c:c16orf59|C16orf59]]|0.616|
|[[:human genes:c:cep120|CEP120]]|0.612|
|[[:human genes:n:nin|NIN]]|0.606|
|[[:human genes:a:ankrd26|ANKRD26]]|0.581|
|[[:human genes:t:tubd1|TUBD1]]|0.516|
|[[:human genes:t:tube1|TUBE1]]|0.505|
|[[:human genes:c:cep78|CEP78]]|0.502|
|[[:human genes:f:fopnl|FOPNL]]|0.499|
|[[:human genes:h:hyls1|HYLS1]]|0.481|
|[[:human genes:r:rttn|RTTN]]|0.474|
|[[:human genes:k:kiaa0586|KIAA0586]]|0.448|
|[[:human genes:c:cep44|CEP44]]|0.445|
|[[:human genes:s:srp9|SRP9]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5413
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ODF2 Expression in NALM6 Cells: 6.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>