======= ONECUT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ONECUT2
  * **<color #00a2e8>Official Name</color>**: one cut homeobox 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9480|9480]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95948|O95948]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ONECUT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ONECUT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604894|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CUT|
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peripheral nervous system neuron development|
|peripheral nervous system neuron differentiation|
|endocrine pancreas development|
|pancreas development|
|peripheral nervous system development|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cell-matrix adhesion|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|endocrine system development|
|liver development|
|hepaticobiliary system development|
|negative regulation of cellular response to growth factor stimulus|
|epithelial cell development|
|regulation of cell-substrate adhesion|
|actin cytoskeleton|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cell fate commitment|
|regulation of cellular response to growth factor stimulus|
|cilium assembly|
|cilium organization|
|gland development|
|plasma membrane bounded cell projection assembly|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|cell projection assembly|
|positive regulation of cell migration|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|epithelial cell differentiation|
|regulation of cell adhesion|
|organelle assembly|
|neuron development|
|regulation of cell migration|
|regulation of cell motility|
|animal organ morphogenesis|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|DNA binding|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-2.05|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.49|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12307
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.85 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ONECUT2 Expression in NALM6 Cells: -0.85'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>