======= OPTN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OPTN
  * **<color #00a2e8>Official Name</color>**: optineurin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10133|10133]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96CV9|Q96CV9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OPTN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OPTN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602432|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NEMO|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of receptor recycling|
|parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization|
|regulation of xenophagy|
|positive regulation of xenophagy|
|positive regulation of mitophagy in response to mitochondrial depolarization|
|positive regulation of mitophagy|
|Golgi ribbon formation|
|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization|
|regulation of autophagy of mitochondrion in response to mitochondrial depolarization|
|regulation of mitophagy|
|positive regulation of autophagy of mitochondrion|
|response to mitochondrial depolarisation|
|K63-linked polyubiquitin modification-dependent protein binding|
|regulation of receptor recycling|
|protein localization to Golgi apparatus|
|polyubiquitin modification-dependent protein binding|
|Golgi to plasma membrane protein transport|
|regulation of autophagy of mitochondrion|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|establishment of protein localization to plasma membrane|
|Golgi to plasma membrane transport|
|positive regulation of macroautophagy|
|autophagosome|
|protein binding, bridging|
|recycling endosome membrane|
|defense response to Gram-negative bacterium|
|vesicle-mediated transport to the plasma membrane|
|post-Golgi vesicle-mediated transport|
|positive regulation of mitochondrion organization|
|positive regulation of autophagy|
|cellular response to unfolded protein|
|G2/M transition of mitotic cell cycle|
|Golgi organization|
|cell cycle G2/M phase transition|
|cellular response to topologically incorrect protein|
|Rab GTPase binding|
|response to unfolded protein|
|trans-Golgi network|
|regulation of macroautophagy|
|regulation of mitochondrion organization|
|protein localization to plasma membrane|
|response to topologically incorrect protein|
|protein C-terminus binding|
|protein localization to cell periphery|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|autophagy|
|process utilizing autophagic mechanism|
|establishment of protein localization to membrane|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|defense response to bacterium|
|regulation of autophagy|
|positive regulation of response to biotic stimulus|
|positive regulation of cellular catabolic process|
|Golgi vesicle transport|
|endomembrane system organization|
|positive regulation of catabolic process|
|positive regulation of defense response|
|protein localization to membrane|
|negative regulation of intracellular signal transduction|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|mitotic cell cycle process|
|positive regulation of response to external stimulus|
|Golgi membrane|
|positive regulation of organelle organization|
|mitotic cell cycle|
|response to bacterium|
|perinuclear region of cytoplasm|
|protein localization to organelle|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of cellular catabolic process|
|defense response to other organism|
|Golgi apparatus|
|regulation of catabolic process|
|cell cycle process|
|identical protein binding|
|cell death|
|regulation of response to external stimulus|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|protein transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|cellular response to stress|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.16|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.15|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-2.03|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.96|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.89|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.84|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.81|
|[[:results:exp149|SB203580 25μM R03 exp149]]|1.84|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.87|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.9|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.96|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8115
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OPTN Expression in NALM6 Cells: 4.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>