======= ORC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ORC1
  * **<color #00a2e8>Official Name</color>**: origin recognition complex subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4998|4998]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13415|Q13415]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ORC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ORC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601902|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cdc6 C|
|BAH|
|AAA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|origin recognition complex|
|nuclear origin of replication recognition complex|
|mitotic DNA replication checkpoint|
|DNA replication checkpoint|
|DNA replication origin binding|
|mitotic G2/M transition checkpoint|
|regulation of transcription involved in G1/S transition of mitotic cell cycle|
|DNA replication initiation|
|negative regulation of G2/M transition of mitotic cell cycle|
|negative regulation of cell cycle G2/M phase transition|
|mitotic DNA integrity checkpoint|
|nuclear chromosome, telomeric region|
|G1/S transition of mitotic cell cycle|
|DNA-dependent DNA replication|
|cell cycle G1/S phase transition|
|DNA integrity checkpoint|
|mitotic cell cycle checkpoint|
|cell cycle checkpoint|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|DNA replication|
|negative regulation of cell cycle phase transition|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|chromatin binding|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|DNA metabolic process|
|regulation of cell cycle process|
|nucleolus|
|cell cycle process|
|regulation of cell cycle|
|cell cycle|
|DNA binding|
|ATP binding|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.3|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-2.28|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.08|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-2.04|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.02|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.93|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.74|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.73|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.74|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.76|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.76|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.79|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.8|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|1.81|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.83|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.86|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.89|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.9|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.92|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.01|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.01|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.02|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.04|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.14|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.14|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|2.21|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.35|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.595|
|[[:human genes:t:tceb3c|TCEB3C]]|0.595|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.584|
|[[:human genes:v:vasn|VASN]]|0.581|
|[[:human genes:c:chd4|CHD4]]|0.572|
|[[:human genes:c:cbwd3|CBWD3]]|0.565|
|[[:human genes:o:orc6|ORC6]]|0.556|
|[[:human genes:m:mt1e|MT1E]]|0.553|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.552|
|[[:human genes:r:rps2|RPS2]]|0.55|
|[[:human genes:c:cope|COPE]]|0.547|
|[[:human genes:p:psmd3|PSMD3]]|0.547|
|[[:human genes:c:cbwd5|CBWD5]]|0.546|
|[[:human genes:t:tfip11|TFIP11]]|0.545|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.542|
|[[:human genes:p:psmb4|PSMB4]]|0.542|
|[[:human genes:c:cbwd6|CBWD6]]|0.537|
|[[:human genes:s:supt6h|SUPT6H]]|0.533|
|[[:human genes:c:c14orf93|C14orf93]]|0.531|
|[[:human genes:c:copg1|COPG1]]|0.53|
|[[:human genes:p:pcf11|PCF11]]|0.528|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.527|
|[[:human genes:g:gar1|GAR1]]|0.525|
|[[:human genes:r:riok2|RIOK2]]|0.518|
|[[:human genes:r:rpl35|RPL35]]|0.515|
|[[:human genes:k:kctd17|KCTD17]]|0.515|
|[[:human genes:f:fam25b|FAM25B]]|0.511|
|[[:human genes:s:slc4a1|SLC4A1]]|0.507|
|[[:human genes:s:sf3a1|SF3A1]]|0.507|
|[[:human genes:n:nupl1|NUPL1]]|0.506|
|[[:human genes:c:cdc6|CDC6]]|0.504|
|[[:human genes:p:pan3|PAN3]]|0.504|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.503|
|[[:human genes:i:igfn1|IGFN1]]|0.502|
|[[:human genes:t:ticrr|TICRR]]|0.502|
|[[:human genes:p:paf1|PAF1]]|0.5|
|[[:human genes:h:hist1h4b|HIST1H4B]]|0.5|
|[[:human genes:c:cln6|CLN6]]|0.499|
|[[:human genes:p:psmc6|PSMC6]]|0.499|
|[[:human genes:r:rps12|RPS12]]|0.498|
|[[:human genes:g:golga6a|GOLGA6A]]|0.498|
|[[:human genes:p:pigs|PIGS]]|0.498|
|[[:human genes:r:rpl14|RPL14]]|0.497|
|[[:human genes:t:twistnb|TWISTNB]]|0.496|
|[[:human genes:c:cdc73|CDC73]]|0.496|
|[[:human genes:h:hivep3|HIVEP3]]|0.496|
|[[:human genes:a:aamp|AAMP]]|0.493|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.492|
|[[:human genes:s:smg1|SMG1]]|0.492|
|[[:human genes:p:polr1a|POLR1A]]|0.492|
|[[:human genes:n:nbpf10|NBPF10]]|0.49|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.49|
|[[:human genes:l:lrr1|LRR1]]|0.489|
|[[:human genes:r:rpl34|RPL34]]|0.487|
|[[:human genes:r:rpl30|RPL30]]|0.487|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.487|
|[[:human genes:r:rad51|RAD51]]|0.486|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.486|
|[[:human genes:p:pan2|PAN2]]|0.485|
|[[:human genes:e:exosc5|EXOSC5]]|0.485|
|[[:human genes:d:disp2|DISP2]]|0.485|
|[[:human genes:i:iscu|ISCU]]|0.485|
|[[:human genes:n:nfatc4|NFATC4]]|0.485|
|[[:human genes:s:s1pr4|S1PR4]]|0.485|
|[[:human genes:a:akirin2|AKIRIN2]]|0.483|
|[[:human genes:r:rbm39|RBM39]]|0.483|
|[[:human genes:d:ddtl|DDTL]]|0.483|
|[[:human genes:r:rrn3|RRN3]]|0.483|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.483|
|[[:human genes:n:nup205|NUP205]]|0.483|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.482|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.482|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.482|
|[[:human genes:i:ik|IK]]|0.482|
|[[:human genes:o:ogfr|OGFR]]|0.481|
|[[:human genes:t:traip|TRAIP]]|0.481|
|[[:human genes:h:hap1|HAP1]]|0.481|
|[[:human genes:c:ctr9|CTR9]]|0.48|
|[[:human genes:a:aatf|AATF]]|0.48|
|[[:human genes:n:npipb5|NPIPB5]]|0.478|
|[[:human genes:c:cactin|CACTIN]]|0.477|
|[[:human genes:g:gprin2|GPRIN2]]|0.476|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.476|
|[[:human genes:n:narfl|NARFL]]|0.473|
|[[:human genes:e:eif4a3|EIF4A3]]|0.473|
|[[:human genes:p:psmd11|PSMD11]]|0.473|
|[[:human genes:p:pole|POLE]]|0.471|
|[[:human genes:s:syt9|SYT9]]|0.471|
|[[:human genes:f:fbxw9|FBXW9]]|0.471|
|[[:human genes:r:rpl6|RPL6]]|0.47|
|[[:human genes:a:ankle1|ANKLE1]]|0.468|
|[[:human genes:n:nup54|NUP54]]|0.468|
|[[:human genes:c:cdca3|CDCA3]]|0.468|
|[[:human genes:p:psmb2|PSMB2]]|0.467|
|[[:human genes:t:timeless|TIMELESS]]|0.467|
|[[:human genes:c:copb1|COPB1]]|0.467|
|[[:human genes:d:dido1|DIDO1]]|0.467|
|[[:human genes:c:c2orf27a|C2orf27A]]|0.466|
|[[:human genes:z:znf106|ZNF106]]|0.466|
|[[:human genes:p:pola2|POLA2]]|0.465|
|[[:human genes:a:aqr|AQR]]|0.465|
|[[:human genes:p:psmc2|PSMC2]]|0.464|
|[[:human genes:t:terf1|TERF1]]|0.464|
|[[:human genes:s:stil|STIL]]|0.464|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.463|
|[[:human genes:g:gon4l|GON4L]]|0.463|
|[[:human genes:m:madcam1|MADCAM1]]|0.463|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.463|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.463|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.462|
|[[:human genes:d:dtl|DTL]]|0.462|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.462|
|[[:human genes:s:smg7|SMG7]]|0.461|
|[[:human genes:s:sec13|SEC13]]|0.461|
|[[:human genes:t:top1mt|TOP1MT]]|0.461|
|[[:human genes:p:psmd1|PSMD1]]|0.461|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.461|
|[[:human genes:r:rps19|RPS19]]|0.461|
|[[:human genes:c:ccna2|CCNA2]]|0.46|
|[[:human genes:n:nol10|NOL10]]|0.46|
|[[:human genes:s:sf3a3|SF3A3]]|0.46|
|[[:human genes:c:copa|COPA]]|0.46|
|[[:human genes:c:ckap5|CKAP5]]|0.459|
|[[:human genes:p:psma6|PSMA6]]|0.459|
|[[:human genes:w:wdr87|WDR87]]|0.458|
|[[:human genes:c:cep192|CEP192]]|0.458|
|[[:human genes:t:tuba8|TUBA8]]|0.457|
|[[:human genes:a:ankle2|ANKLE2]]|0.456|
|[[:human genes:s:ssh2|SSH2]]|0.456|
|[[:human genes:r:rrp7a|RRP7A]]|0.456|
|[[:human genes:c:ccdc94|CCDC94]]|0.455|
|[[:human genes:g:golga8o|GOLGA8O]]|0.455|
|[[:human genes:p:psmd14|PSMD14]]|0.454|
|[[:human genes:b:bysl|BYSL]]|0.454|
|[[:human genes:e:elmod3|ELMOD3]]|0.453|
|[[:human genes:e:exd1|EXD1]]|0.453|
|[[:human genes:n:nup160|NUP160]]|0.452|
|[[:human genes:s:scaf1|SCAF1]]|0.451|
|[[:human genes:r:rbbp5|RBBP5]]|0.451|
|[[:human genes:s:snrnp70|SNRNP70]]|0.451|
|[[:human genes:n:nbpf16|NBPF16]]|0.449|
|[[:human genes:a:arcn1|ARCN1]]|0.447|
|[[:human genes:p:pole2|POLE2]]|0.446|
|[[:human genes:p:psap|PSAP]]|0.445|
|[[:human genes:i:ints5|INTS5]]|0.445|
|[[:human genes:p:psmd7|PSMD7]]|0.445|
|[[:human genes:t:tyms|TYMS]]|0.445|
|[[:human genes:m:med17|MED17]]|0.445|
|[[:human genes:r:rrp15|RRP15]]|0.444|
|[[:human genes:t:tspy8|TSPY8]]|0.443|
|[[:human genes:m:mdm2|MDM2]]|0.442|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.442|
|[[:human genes:p:polr2f|POLR2F]]|0.441|
|[[:human genes:u:upf1|UPF1]]|0.441|
|[[:human genes:k:krt2|KRT2]]|0.441|
|[[:human genes:e:egr2|EGR2]]|0.44|
|[[:human genes:p:polr2j3|POLR2J3]]|0.44|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.439|
|[[:human genes:r:rps14|RPS14]]|0.439|
|[[:human genes:f:fam160a1|FAM160A1]]|0.438|
|[[:human genes:k:kif3c|KIF3C]]|0.438|
|[[:human genes:g:gid4|GID4]]|0.438|
|[[:human genes:x:xylt2|XYLT2]]|0.437|
|[[:human genes:x:xab2|XAB2]]|0.437|
|[[:human genes:v:vps54|VPS54]]|0.437|
|[[:human genes:c:cnpy3|CNPY3]]|0.437|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.436|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.436|
|[[:human genes:h:hmgcr|HMGCR]]|0.436|
|[[:human genes:l:loc643669|LOC643669]]|0.436|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.436|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.436|
|[[:human genes:s:snrpa1|SNRPA1]]|0.436|
|[[:human genes:r:rpl37a|RPL37A]]|0.435|
|[[:human genes:t:tsg101|TSG101]]|0.435|
|[[:human genes:n:nol12|NOL12]]|0.435|
|[[:human genes:r:ranbp2|RANBP2]]|0.434|
|[[:human genes:c:cwc22|CWC22]]|0.433|
|[[:human genes:c:chaf1a|CHAF1A]]|0.433|
|[[:human genes:a:acsf2|ACSF2]]|0.433|
|[[:human genes:e:exosc8|EXOSC8]]|0.433|
|[[:human genes:o:or10g3|OR10G3]]|0.431|
|[[:human genes:s:strn|STRN]]|0.431|
|[[:human genes:n:nup85|NUP85]]|0.43|
|[[:human genes:g:gpx4|GPX4]]|0.429|
|[[:human genes:e:exosc9|EXOSC9]]|0.429|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.429|
|[[:human genes:a:add2|ADD2]]|0.428|
|[[:human genes:k:kpnb1|KPNB1]]|0.428|
|[[:human genes:u:uqcrh|UQCRH]]|0.428|
|[[:human genes:h:hist2h3d|HIST2H3D]]|0.427|
|[[:human genes:h:hk1|HK1]]|0.427|
|[[:human genes:u:ubap1|UBAP1]]|0.426|
|[[:human genes:r:rps7|RPS7]]|0.425|
|[[:human genes:s:sult1a3|SULT1A3]]|0.425|
|[[:human genes:m:myo1h|MYO1H]]|0.425|
|[[:human genes:s:sult1a4|SULT1A4]]|0.425|
|[[:human genes:c:copb2|COPB2]]|0.425|
|[[:human genes:r:rnf113a|RNF113A]]|0.424|
|[[:human genes:m:myb|MYB]]|0.423|
|[[:human genes:s:supt5h|SUPT5H]]|0.423|
|[[:human genes:m:mylk3|MYLK3]]|0.423|
|[[:human genes:r:rps5|RPS5]]|0.423|
|[[:human genes:g:golga8j|GOLGA8J]]|0.423|
|[[:human genes:t:taf1|TAF1]]|0.422|
|[[:human genes:n:npipa7|NPIPA7]]|0.422|
|[[:human genes:n:napa|NAPA]]|0.422|
|[[:human genes:n:npipa8|NPIPA8]]|0.422|
|[[:human genes:m:med29|MED29]]|0.422|
|[[:human genes:z:znf655|ZNF655]]|0.422|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.422|
|[[:human genes:p:polr2d|POLR2D]]|0.421|
|[[:human genes:r:rpsa|RPSA]]|0.421|
|[[:human genes:p:psmb1|PSMB1]]|0.421|
|[[:human genes:p:plk4|PLK4]]|0.42|
|[[:human genes:p:pola1|POLA1]]|0.42|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.419|
|[[:human genes:n:nup93|NUP93]]|0.419|
|[[:human genes:s:slc5a5|SLC5A5]]|0.418|
|[[:human genes:n:nup107|NUP107]]|0.418|
|[[:human genes:t:terf2|TERF2]]|0.418|
|[[:human genes:l:lipe|LIPE]]|0.418|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.418|
|[[:human genes:p:polr2a|POLR2A]]|0.418|
|[[:human genes:r:rps3a|RPS3A]]|0.418|
|[[:human genes:a:abt1|ABT1]]|0.418|
|[[:human genes:c:chmp2a|CHMP2A]]|0.418|
|[[:human genes:n:nufip2|NUFIP2]]|0.417|
|[[:human genes:s:snip1|SNIP1]]|0.417|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.417|
|[[:human genes:c:ctage4|CTAGE4]]|0.417|
|[[:human genes:v:vps28|VPS28]]|0.416|
|[[:human genes:d:dock6|DOCK6]]|0.416|
|[[:human genes:s:sf3b5|SF3B5]]|0.416|
|[[:human genes:u:utp3|UTP3]]|0.416|
|[[:human genes:m:msh5|MSH5]]|0.415|
|[[:human genes:w:wdr43|WDR43]]|0.415|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.415|
|[[:human genes:n:nckap1l|NCKAP1L]]|0.415|
|[[:human genes:m:myo18a|MYO18A]]|0.415|
|[[:human genes:c:cgb2|CGB2]]|0.414|
|[[:human genes:c:casc3|CASC3]]|0.414|
|[[:human genes:n:npipb8|NPIPB8]]|0.412|
|[[:human genes:m:mcoln1|MCOLN1]]|0.411|
|[[:human genes:i:itga2b|ITGA2B]]|0.411|
|[[:human genes:p:psma7|PSMA7]]|0.411|
|[[:human genes:p:psmd6|PSMD6]]|0.41|
|[[:human genes:c:col2a1|COL2A1]]|0.41|
|[[:human genes:s:slc38a7|SLC38A7]]|0.409|
|[[:human genes:r:rad21|RAD21]]|0.409|
|[[:human genes:a:atxn1|ATXN1]]|0.409|
|[[:human genes:n:nop16|NOP16]]|0.409|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.409|
|[[:human genes:d:ddx56|DDX56]]|0.409|
|[[:human genes:g:gnb3|GNB3]]|0.408|
|[[:human genes:n:nup188|NUP188]]|0.408|
|[[:human genes:z:znf574|ZNF574]]|0.408|
|[[:human genes:r:rps9|RPS9]]|0.408|
|[[:human genes:y:ythdc1|YTHDC1]]|0.408|
|[[:human genes:e:esf1|ESF1]]|0.408|
|[[:human genes:c:crnkl1|CRNKL1]]|0.408|
|[[:human genes:s:sel1l|SEL1L]]|0.407|
|[[:human genes:p:parp3|PARP3]]|0.407|
|[[:human genes:i:ints6|INTS6]]|0.407|
|[[:human genes:r:rffl|RFFL]]|0.407|
|[[:human genes:b:bid|BID]]|0.407|
|[[:human genes:n:nup43|NUP43]]|0.406|
|[[:human genes:f:fcn2|FCN2]]|0.406|
|[[:human genes:k:krt78|KRT78]]|0.406|
|[[:human genes:r:rps28|RPS28]]|0.405|
|[[:human genes:c:cdc45|CDC45]]|0.404|
|[[:human genes:n:nup133|NUP133]]|0.404|
|[[:human genes:t:tspy1|TSPY1]]|0.404|
|[[:human genes:p:psmb3|PSMB3]]|0.403|
|[[:human genes:p:prmt8|PRMT8]]|0.402|
|[[:human genes:r:rpl7a|RPL7A]]|0.402|
|[[:human genes:o:osbp|OSBP]]|0.402|
|[[:human genes:m:med14|MED14]]|0.402|
|[[:human genes:r:rnf4|RNF4]]|0.402|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.402|
|[[:human genes:n:numa1|NUMA1]]|0.402|
|[[:human genes:c:cmya5|CMYA5]]|0.401|
|[[:human genes:z:zfand5|ZFAND5]]|0.4|
|[[:human genes:c:cdk12|CDK12]]|0.4|
|[[:human genes:n:nup155|NUP155]]|0.4|
|[[:human genes:r:rps3|RPS3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 133/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|4/28|
|bone|3/26|
|breast|10/33|
|central nervous system|9/56|
|cervix|1/4|
|colorectal|4/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|2/21|
|liver|3/20|
|lung|16/75|
|lymphocyte|7/16|
|ovary|3/26|
|pancreas|1/24|
|peripheral nervous system|6/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|6/22|
|urinary tract|1/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 640
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ORC1 Expression in NALM6 Cells: 6.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>