======= ORC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ORC3
  * **<color #00a2e8>Official Name</color>**: origin recognition complex subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23595|23595]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBD5|Q9UBD5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ORC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ORC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604972|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ORC3 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA replication preinitiation complex|
|nuclear pre-replicative complex|
|origin recognition complex|
|pre-replicative complex assembly involved in cell cycle DNA replication|
|pre-replicative complex assembly|
|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|
|nuclear origin of replication recognition complex|
|DNA replication origin binding|
|DNA replication initiation|
|nuclear DNA replication|
|cell cycle DNA replication|
|neural precursor cell proliferation|
|nuclear chromosome, telomeric region|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|DNA-dependent DNA replication|
|protein-DNA complex assembly|
|DNA replication|
|protein-DNA complex subunit organization|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|nuclear body|
|cell population proliferation|
|mitotic cell cycle process|
|mitotic cell cycle|
|DNA metabolic process|
|cellular protein-containing complex assembly|
|cell cycle process|
|cell cycle|
|protein-containing complex assembly|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-3.44|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.64|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-2.54|
|[[:results:exp16|DABN 2μM R00 exp16]]|-2.5|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-2.49|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.45|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.43|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-2.43|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.38|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-2.38|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.37|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-2.36|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.36|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-2.29|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-2.27|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.09|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-2.09|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.06|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.02|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.99|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.97|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.97|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.93|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.92|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.91|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.89|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.89|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.83|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.81|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.81|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.8|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.79|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-1.79|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.76|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.74|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.471|
|[[:human genes:d:dhps|DHPS]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1694
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ORC3 Expression in NALM6 Cells: 5.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>