======= ORC6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ORC6
  * **<color #00a2e8>Official Name</color>**: origin recognition complex subunit 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23594|23594]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5N6|Q9Y5N6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ORC6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ORC6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607213|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. {ECO:0000269|PubMed:22427655}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ORC6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|origin recognition complex|
|nuclear origin of replication recognition complex|
|negative regulation of cell division|
|DNA replication origin binding|
|DNA replication initiation|
|G1/S transition of mitotic cell cycle|
|DNA-dependent DNA replication|
|cell cycle G1/S phase transition|
|fibrillar center|
|regulation of cell division|
|DNA replication|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|mitotic cell cycle process|
|mitotic cell cycle|
|DNA metabolic process|
|cell cycle process|
|cell cycle|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.82|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.7|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.78|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.8|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.84|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.85|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.86|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.87|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.9|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.92|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.95|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.95|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|2.01|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|2.03|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.07|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.24|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.38|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.45|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.53|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.582|
|[[:human genes:t:tfip11|TFIP11]]|0.563|
|[[:human genes:o:orc1|ORC1]]|0.556|
|[[:human genes:t:tceb3c|TCEB3C]]|0.555|
|[[:human genes:r:rrn3|RRN3]]|0.553|
|[[:human genes:c:chd4|CHD4]]|0.548|
|[[:human genes:p:pola2|POLA2]]|0.546|
|[[:human genes:p:psmd3|PSMD3]]|0.543|
|[[:human genes:t:ticrr|TICRR]]|0.543|
|[[:human genes:r:rps2|RPS2]]|0.54|
|[[:human genes:d:dtl|DTL]]|0.532|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.529|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.528|
|[[:human genes:v:vasn|VASN]]|0.528|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.527|
|[[:human genes:s:snrpa1|SNRPA1]]|0.522|
|[[:human genes:c:ccna2|CCNA2]]|0.519|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.519|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.517|
|[[:human genes:g:golga6a|GOLGA6A]]|0.515|
|[[:human genes:m:mt1e|MT1E]]|0.509|
|[[:human genes:s:supt6h|SUPT6H]]|0.508|
|[[:human genes:c:cdc6|CDC6]]|0.508|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.506|
|[[:human genes:a:acsf2|ACSF2]]|0.504|
|[[:human genes:s:slc4a1|SLC4A1]]|0.503|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.502|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.502|
|[[:human genes:p:psma6|PSMA6]]|0.5|
|[[:human genes:k:kctd17|KCTD17]]|0.499|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.499|
|[[:human genes:a:ankle1|ANKLE1]]|0.495|
|[[:human genes:p:psmb4|PSMB4]]|0.495|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.494|
|[[:human genes:c:copg1|COPG1]]|0.493|
|[[:human genes:h:hist1h4b|HIST1H4B]]|0.493|
|[[:human genes:c:cdc73|CDC73]]|0.491|
|[[:human genes:c:cln6|CLN6]]|0.49|
|[[:human genes:a:akirin2|AKIRIN2]]|0.49|
|[[:human genes:c:copb1|COPB1]]|0.489|
|[[:human genes:r:rpl35|RPL35]]|0.489|
|[[:human genes:p:pcf11|PCF11]]|0.487|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.485|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.484|
|[[:human genes:r:rbm39|RBM39]]|0.483|
|[[:human genes:a:arcn1|ARCN1]]|0.483|
|[[:human genes:n:narfl|NARFL]]|0.483|
|[[:human genes:p:polr2j3|POLR2J3]]|0.483|
|[[:human genes:c:c14orf93|C14orf93]]|0.482|
|[[:human genes:p:pole|POLE]]|0.481|
|[[:human genes:s:sf3a3|SF3A3]]|0.481|
|[[:human genes:n:nupl1|NUPL1]]|0.48|
|[[:human genes:r:rad51|RAD51]]|0.48|
|[[:human genes:n:napa|NAPA]]|0.478|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.477|
|[[:human genes:s:snip1|SNIP1]]|0.474|
|[[:human genes:c:col2a1|COL2A1]]|0.472|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.471|
|[[:human genes:m:myo1h|MYO1H]]|0.47|
|[[:human genes:p:psmc6|PSMC6]]|0.47|
|[[:human genes:n:nol10|NOL10]]|0.469|
|[[:human genes:s:ssh2|SSH2]]|0.469|
|[[:human genes:s:snrnp70|SNRNP70]]|0.469|
|[[:human genes:n:nop16|NOP16]]|0.467|
|[[:human genes:k:krt78|KRT78]]|0.466|
|[[:human genes:r:rps3a|RPS3A]]|0.466|
|[[:human genes:c:cbwd3|CBWD3]]|0.466|
|[[:human genes:s:sec13|SEC13]]|0.465|
|[[:human genes:i:ik|IK]]|0.464|
|[[:human genes:c:cbwd5|CBWD5]]|0.464|
|[[:human genes:n:npipb5|NPIPB5]]|0.464|
|[[:human genes:h:hap1|HAP1]]|0.464|
|[[:human genes:r:rpl34|RPL34]]|0.463|
|[[:human genes:p:paf1|PAF1]]|0.463|
|[[:human genes:m:myt1l|MYT1L]]|0.462|
|[[:human genes:p:psmd11|PSMD11]]|0.462|
|[[:human genes:w:wdr87|WDR87]]|0.462|
|[[:human genes:d:dock6|DOCK6]]|0.462|
|[[:human genes:e:exd1|EXD1]]|0.461|
|[[:human genes:p:psmb2|PSMB2]]|0.461|
|[[:human genes:c:ctr9|CTR9]]|0.46|
|[[:human genes:a:aamp|AAMP]]|0.46|
|[[:human genes:r:rps12|RPS12]]|0.46|
|[[:human genes:g:gosr2|GOSR2]]|0.458|
|[[:human genes:c:cdca3|CDCA3]]|0.458|
|[[:human genes:p:phf2|PHF2]]|0.458|
|[[:human genes:u:upf1|UPF1]]|0.457|
|[[:human genes:f:fam160a1|FAM160A1]]|0.457|
|[[:human genes:s:sap30bp|SAP30BP]]|0.457|
|[[:human genes:t:tspy1|TSPY1]]|0.457|
|[[:human genes:p:pan3|PAN3]]|0.457|
|[[:human genes:b:bysl|BYSL]]|0.456|
|[[:human genes:p:psmd14|PSMD14]]|0.456|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.455|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.455|
|[[:human genes:r:rrp15|RRP15]]|0.455|
|[[:human genes:p:ppfia4|PPFIA4]]|0.455|
|[[:human genes:p:plekha4|PLEKHA4]]|0.454|
|[[:human genes:e:egr2|EGR2]]|0.453|
|[[:human genes:s:sf3a1|SF3A1]]|0.452|
|[[:human genes:p:pan2|PAN2]]|0.452|
|[[:human genes:s:slc6a17|SLC6A17]]|0.452|
|[[:human genes:u:utp3|UTP3]]|0.452|
|[[:human genes:m:mylk3|MYLK3]]|0.451|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.45|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.45|
|[[:human genes:n:nup54|NUP54]]|0.448|
|[[:human genes:s:stil|STIL]]|0.448|
|[[:human genes:e:exosc6|EXOSC6]]|0.448|
|[[:human genes:d:ddtl|DDTL]]|0.446|
|[[:human genes:g:gon4l|GON4L]]|0.446|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.446|
|[[:human genes:z:znf148|ZNF148]]|0.446|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.445|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.445|
|[[:human genes:u:ubap1|UBAP1]]|0.444|
|[[:human genes:t:tspy8|TSPY8]]|0.444|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.444|
|[[:human genes:p:psmb1|PSMB1]]|0.443|
|[[:human genes:p:psmb3|PSMB3]]|0.443|
|[[:human genes:p:ppm1d|PPM1D]]|0.443|
|[[:human genes:t:tsg101|TSG101]]|0.443|
|[[:human genes:r:rpl9|RPL9]]|0.443|
|[[:human genes:a:atxn1|ATXN1]]|0.442|
|[[:human genes:s:syt9|SYT9]]|0.442|
|[[:human genes:n:nckap1l|NCKAP1L]]|0.441|
|[[:human genes:i:iscu|ISCU]]|0.44|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.44|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.439|
|[[:human genes:i:igfn1|IGFN1]]|0.439|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.438|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.438|
|[[:human genes:d:dido1|DIDO1]]|0.438|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.437|
|[[:human genes:s:supt5h|SUPT5H]]|0.437|
|[[:human genes:a:aatf|AATF]]|0.437|
|[[:human genes:m:mfsd12|MFSD12]]|0.437|
|[[:human genes:x:xylt2|XYLT2]]|0.437|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.437|
|[[:human genes:s:samd1|SAMD1]]|0.437|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.436|
|[[:human genes:n:nbpf10|NBPF10]]|0.436|
|[[:human genes:c:cdt1|CDT1]]|0.436|
|[[:human genes:a:ankle2|ANKLE2]]|0.436|
|[[:human genes:p:polr1a|POLR1A]]|0.436|
|[[:human genes:r:rfxank|RFXANK]]|0.435|
|[[:human genes:r:rpl10a|RPL10A]]|0.435|
|[[:human genes:p:pigs|PIGS]]|0.433|
|[[:human genes:l:lrr1|LRR1]]|0.433|
|[[:human genes:a:aqr|AQR]]|0.433|
|[[:human genes:r:ranbp2|RANBP2]]|0.432|
|[[:human genes:c:copa|COPA]]|0.432|
|[[:human genes:c:ctage4|CTAGE4]]|0.431|
|[[:human genes:z:znf541|ZNF541]]|0.431|
|[[:human genes:n:ncl|NCL]]|0.431|
|[[:human genes:r:rpl14|RPL14]]|0.431|
|[[:human genes:o:osbp|OSBP]]|0.43|
|[[:human genes:t:tyms|TYMS]]|0.43|
|[[:human genes:z:zfand5|ZFAND5]]|0.429|
|[[:human genes:c:chmp2a|CHMP2A]]|0.429|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.429|
|[[:human genes:p:psmc1|PSMC1]]|0.429|
|[[:human genes:c:cdc45|CDC45]]|0.429|
|[[:human genes:c:cgb2|CGB2]]|0.428|
|[[:human genes:c:cactin|CACTIN]]|0.428|
|[[:human genes:c:cbwd6|CBWD6]]|0.428|
|[[:human genes:p:plk1|PLK1]]|0.428|
|[[:human genes:c:ckap5|CKAP5]]|0.427|
|[[:human genes:r:rpp40|RPP40]]|0.427|
|[[:human genes:n:nfatc4|NFATC4]]|0.427|
|[[:human genes:s:slc5a5|SLC5A5]]|0.427|
|[[:human genes:o:ogfr|OGFR]]|0.426|
|[[:human genes:r:rps19|RPS19]]|0.426|
|[[:human genes:f:fbxw9|FBXW9]]|0.425|
|[[:human genes:t:twistnb|TWISTNB]]|0.425|
|[[:human genes:r:rps28|RPS28]]|0.424|
|[[:human genes:t:topbp1|TOPBP1]]|0.423|
|[[:human genes:w:wdr43|WDR43]]|0.422|
|[[:human genes:r:rpl6|RPL6]]|0.422|
|[[:human genes:p:psmc2|PSMC2]]|0.421|
|[[:human genes:e:eif4a3|EIF4A3]]|0.421|
|[[:human genes:p:psmd8|PSMD8]]|0.42|
|[[:human genes:c:cdh24|CDH24]]|0.42|
|[[:human genes:r:rps5|RPS5]]|0.42|
|[[:human genes:p:psmd2|PSMD2]]|0.42|
|[[:human genes:r:ran|RAN]]|0.419|
|[[:human genes:t:timeless|TIMELESS]]|0.419|
|[[:human genes:n:nup43|NUP43]]|0.419|
|[[:human genes:p:polr2a|POLR2A]]|0.419|
|[[:human genes:s:smg1|SMG1]]|0.417|
|[[:human genes:o:or10g3|OR10G3]]|0.416|
|[[:human genes:r:rbbp5|RBBP5]]|0.416|
|[[:human genes:p:psap|PSAP]]|0.416|
|[[:human genes:a:abt1|ABT1]]|0.416|
|[[:human genes:s:strn|STRN]]|0.415|
|[[:human genes:s:srgap2c|SRGAP2C]]|0.415|
|[[:human genes:e:eif3g|EIF3G]]|0.414|
|[[:human genes:d:disp2|DISP2]]|0.414|
|[[:human genes:n:nup133|NUP133]]|0.413|
|[[:human genes:n:nsf|NSF]]|0.413|
|[[:human genes:g:golga6b|GOLGA6B]]|0.412|
|[[:human genes:r:rnf113a|RNF113A]]|0.412|
|[[:human genes:t:traip|TRAIP]]|0.411|
|[[:human genes:g:gid4|GID4]]|0.411|
|[[:human genes:p:psmd1|PSMD1]]|0.411|
|[[:human genes:k:kpnb1|KPNB1]]|0.411|
|[[:human genes:n:npipb8|NPIPB8]]|0.41|
|[[:human genes:c:cep192|CEP192]]|0.41|
|[[:human genes:t:tspy2|TSPY2]]|0.41|
|[[:human genes:c:crnkl1|CRNKL1]]|0.41|
|[[:human genes:u:uqcrh|UQCRH]]|0.41|
|[[:human genes:p:psmc5|PSMC5]]|0.409|
|[[:human genes:s:smg7|SMG7]]|0.409|
|[[:human genes:r:rps3|RPS3]]|0.409|
|[[:human genes:c:copz1|COPZ1]]|0.408|
|[[:human genes:v:vps54|VPS54]]|0.408|
|[[:human genes:n:nbpf16|NBPF16]]|0.407|
|[[:human genes:s:sult2b1|SULT2B1]]|0.407|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.406|
|[[:human genes:p:psmc4|PSMC4]]|0.406|
|[[:human genes:z:znf106|ZNF106]]|0.405|
|[[:human genes:p:polr2d|POLR2D]]|0.405|
|[[:human genes:s:sf3b5|SF3B5]]|0.404|
|[[:human genes:n:nup160|NUP160]]|0.404|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.403|
|[[:human genes:s:s1pr4|S1PR4]]|0.402|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.402|
|[[:human genes:h:hivep3|HIVEP3]]|0.402|
|[[:human genes:a:add2|ADD2]]|0.402|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.402|
|[[:human genes:r:rps14|RPS14]]|0.402|
|[[:human genes:n:nup85|NUP85]]|0.401|
|[[:human genes:c:copb2|COPB2]]|0.401|
|[[:human genes:r:rrp7a|RRP7A]]|0.4|
|[[:human genes:f:fbxo5|FBXO5]]|0.4|
|[[:human genes:l:lad1|LAD1]]|0.4|
|[[:human genes:c:cope|COPE]]|0.4|
|[[:human genes:p:plk4|PLK4]]|0.4|
|[[:human genes:t:tgm5|TGM5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 702/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|27/28|
|bone|26/26|
|breast|31/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|19/20|
|lung|70/75|
|lymphocyte|16/16|
|ovary|21/26|
|pancreas|21/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|17/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1052
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ORC6 Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>