======= OSGEP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OSGEP
  * **<color #00a2e8>Official Name</color>**: O-sialoglycoprotein endopeptidase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55644|55644]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NPF4|Q9NPF4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OSGEP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OSGEP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610107|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. {ECO:0000255|HAMAP-Rule:MF_03180}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M22|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|N(6)-L-threonylcarbamoyladenine synthase activity|
|tRNA threonylcarbamoyladenosine modification|
|EKC/KEOPS complex|
|tRNA threonylcarbamoyladenosine metabolic process|
|tRNA modification|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|ncRNA processing|
|nuclear speck|
|ncRNA metabolic process|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-2.65|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.4|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.2|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-2.11|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-2.1|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-2.07|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-2.04|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.03|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.93|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.91|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.9|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.89|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.87|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.86|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-1.86|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.84|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.84|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.84|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-1.83|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.78|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.77|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.75|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.73|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.73|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.72|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.71|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rtcb|RTCB]]|0.613|
|[[:human genes:r:rpp21|RPP21]]|0.61|
|[[:human genes:g:gmppb|GMPPB]]|0.581|
|[[:human genes:t:thg1l|THG1L]]|0.566|
|[[:human genes:r:rnmt|RNMT]]|0.559|
|[[:human genes:a:alg1|ALG1]]|0.556|
|[[:human genes:g:gnb1l|GNB1L]]|0.549|
|[[:human genes:u:uhrf1|UHRF1]]|0.534|
|[[:human genes:d:ddx20|DDX20]]|0.531|
|[[:human genes:a:alg2|ALG2]]|0.529|
|[[:human genes:e:eprs|EPRS]]|0.522|
|[[:human genes:g:gfpt1|GFPT1]]|0.513|
|[[:human genes:d:dpagt1|DPAGT1]]|0.513|
|[[:human genes:p:pmm2|PMM2]]|0.512|
|[[:human genes:t:tprkb|TPRKB]]|0.511|
|[[:human genes:r:rptor|RPTOR]]|0.509|
|[[:human genes:u:uap1|UAP1]]|0.507|
|[[:human genes:d:ddost|DDOST]]|0.507|
|[[:human genes:n:nae1|NAE1]]|0.507|
|[[:human genes:t:tsen34|TSEN34]]|0.501|
|[[:human genes:n:nars|NARS]]|0.501|
|[[:human genes:c:crcp|CRCP]]|0.5|
|[[:human genes:n:nsmce1|NSMCE1]]|0.5|
|[[:human genes:d:dhps|DHPS]]|0.498|
|[[:human genes:a:atxn10|ATXN10]]|0.498|
|[[:human genes:a:adsl|ADSL]]|0.495|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.495|
|[[:human genes:a:alg13|ALG13]]|0.493|
|[[:human genes:h:hars|HARS]]|0.49|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.489|
|[[:human genes:m:med16|MED16]]|0.489|
|[[:human genes:t:tti2|TTI2]]|0.488|
|[[:human genes:d:dctn6|DCTN6]]|0.486|
|[[:human genes:e:exoc4|EXOC4]]|0.484|
|[[:human genes:y:yars|YARS]]|0.475|
|[[:human genes:e:elp2|ELP2]]|0.474|
|[[:human genes:t:tsen54|TSEN54]]|0.471|
|[[:human genes:p:polr3h|POLR3H]]|0.467|
|[[:human genes:h:haus8|HAUS8]]|0.465|
|[[:human genes:s:snapc5|SNAPC5]]|0.464|
|[[:human genes:a:aars|AARS]]|0.464|
|[[:human genes:v:vezt|VEZT]]|0.463|
|[[:human genes:e:eif4e|EIF4E]]|0.459|
|[[:human genes:s:srp14|SRP14]]|0.457|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.455|
|[[:human genes:r:rpn1|RPN1]]|0.455|
|[[:human genes:d:dohh|DOHH]]|0.454|
|[[:human genes:d:dhdds|DHDDS]]|0.453|
|[[:human genes:t:tti1|TTI1]]|0.451|
|[[:human genes:c:ccdc101|CCDC101]]|0.45|
|[[:human genes:g:gemin8|GEMIN8]]|0.448|
|[[:human genes:e:eny2|ENY2]]|0.443|
|[[:human genes:g:gemin6|GEMIN6]]|0.443|
|[[:human genes:c:cbfb|CBFB]]|0.441|
|[[:human genes:p:pam16|PAM16]]|0.441|
|[[:human genes:t:trmt5|TRMT5]]|0.441|
|[[:human genes:c:cmtr1|CMTR1]]|0.437|
|[[:human genes:p:pelo|PELO]]|0.433|
|[[:human genes:t:telo2|TELO2]]|0.433|
|[[:human genes:z:znf259|ZNF259]]|0.432|
|[[:human genes:t:ten1|TEN1]]|0.432|
|[[:human genes:h:hspd1|HSPD1]]|0.429|
|[[:human genes:d:ddx1|DDX1]]|0.429|
|[[:human genes:s:srp68|SRP68]]|0.428|
|[[:human genes:c:csnk2b|CSNK2B]]|0.427|
|[[:human genes:d:dad1|DAD1]]|0.426|
|[[:human genes:g:gemin5|GEMIN5]]|0.426|
|[[:human genes:e:elac2|ELAC2]]|0.423|
|[[:human genes:t:tgs1|TGS1]]|0.421|
|[[:human genes:t:tbca|TBCA]]|0.421|
|[[:human genes:r:rbm14|RBM14]]|0.418|
|[[:human genes:r:rad1|RAD1]]|0.418|
|[[:human genes:r:rpe|RPE]]|0.417|
|[[:human genes:b:bub3|BUB3]]|0.417|
|[[:human genes:e:exoc3|EXOC3]]|0.416|
|[[:human genes:r:rabggtb|RABGGTB]]|0.415|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.415|
|[[:human genes:s:sugt1|SUGT1]]|0.415|
|[[:human genes:s:spcs2|SPCS2]]|0.41|
|[[:human genes:p:ppcs|PPCS]]|0.41|
|[[:human genes:v:vmp1|VMP1]]|0.409|
|[[:human genes:w:wdr24|WDR24]]|0.409|
|[[:human genes:t:tp53rk|TP53RK]]|0.408|
|[[:human genes:u:utp23|UTP23]]|0.408|
|[[:human genes:a:alg14|ALG14]]|0.408|
|[[:human genes:f:fnta|FNTA]]|0.407|
|[[:human genes:c:c21orf59|C21orf59]]|0.406|
|[[:human genes:g:gtf3c5|GTF3C5]]|0.406|
|[[:human genes:m:med4|MED4]]|0.406|
|[[:human genes:t:tmem41b|TMEM41B]]|0.405|
|[[:human genes:t:triap1|TRIAP1]]|0.404|
|[[:human genes:m:mapk14|MAPK14]]|0.403|
|[[:human genes:e:eef1e1|EEF1E1]]|0.403|
|[[:human genes:f:fbxw7|FBXW7]]|0.403|
|[[:human genes:u:urm1|URM1]]|0.403|
|[[:human genes:m:mtor|MTOR]]|0.402|
|[[:human genes:s:shoc2|SHOC2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 719/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|24/26|
|breast|30/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|16/16|
|ovary|24/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|28/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 284
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OSGEP Expression in NALM6 Cells: 6.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>