======= P2RY1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: P2RY1
  * **<color #00a2e8>Official Name</color>**: purinergic receptor P2Y1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5028|5028]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P47900|P47900]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=P2RY1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20P2RY1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601167|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. {ECO:0000269|PubMed:9442040}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|A1 adenosine receptor binding|
|ADP-activated adenosine receptor activity|
|ATP-activated adenosine receptor activity|
|positive regulation of penile erection|
|positive regulation of inositol trisphosphate biosynthetic process|
|regulation of penile erection|
|regulation of inositol trisphosphate biosynthetic process|
|negative regulation of norepinephrine secretion|
|adenosine receptor signaling pathway|
|G protein-coupled purinergic nucleotide receptor activity|
|cellular response to purine-containing compound|
|G protein-coupled purinergic nucleotide receptor signaling pathway|
|positive regulation of inositol phosphate biosynthetic process|
|integral component of presynaptic active zone membrane|
|negative regulation of catecholamine secretion|
|regulation of norepinephrine secretion|
|regulation of inositol phosphate biosynthetic process|
|regulation of presynaptic cytosolic calcium ion concentration|
|cellular response to ATP|
|signal transduction involved in regulation of gene expression|
|G protein-coupled purinergic receptor signaling pathway|
|purinergic nucleotide receptor signaling pathway|
|relaxation of muscle|
|negative regulation of amine transport|
|positive regulation of alcohol biosynthetic process|
|purinergic receptor signaling pathway|
|eating behavior|
|response to ATP|
|neuron cellular homeostasis|
|glial cell migration|
|ADP binding|
|positive regulation of cellular carbohydrate metabolic process|
|scaffold protein binding|
|regulation of catecholamine secretion|
|cellular response to nutrient|
|cell body|
|sensory perception of pain|
|regulation of alcohol biosynthetic process|
|regulation of synaptic vesicle exocytosis|
|positive regulation of reproductive process|
|positive regulation of carbohydrate metabolic process|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|feeding behavior|
|regulation of amine transport|
|regulation of carbohydrate biosynthetic process|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|positive regulation of hormone secretion|
|response to organophosphorus|
|positive regulation of small molecule metabolic process|
|platelet activation|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of cellular carbohydrate metabolic process|
|regulation of tube size|
|regulation of neurotransmitter transport|
|regulation of cell shape|
|response to purine-containing compound|
|regulation of reproductive process|
|regulation of regulated secretory pathway|
|vascular process in circulatory system|
|negative regulation of binding|
|regulation of signaling receptor activity|
|protein localization to plasma membrane|
|basolateral plasma membrane|
|cilium|
|postsynaptic membrane|
|negative regulation of secretion by cell|
|regulation of carbohydrate metabolic process|
|signaling receptor activity|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|positive regulation of ERK1 and ERK2 cascade|
|response to mechanical stimulus|
|gliogenesis|
|response to nutrient|
|regulation of exocytosis|
|protein localization to cell periphery|
|negative regulation of secretion|
|cellular response to nutrient levels|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|postsynaptic density|
|cellular response to extracellular stimulus|
|regulation of hormone secretion|
|positive regulation of ion transport|
|aging|
|positive regulation of cytosolic calcium ion concentration|
|blood coagulation|
|regulation of ERK1 and ERK2 cascade|
|coagulation|
|hemostasis|
|muscle system process|
|apical plasma membrane|
|regulation of cytosolic calcium ion concentration|
|cellular response to external stimulus|
|anatomical structure homeostasis|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|regulation of binding|
|blood circulation|
|circulatory system process|
|cellular response to drug|
|positive regulation of secretion by cell|
|dendrite|
|regulation of small molecule metabolic process|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|wound healing|
|protein localization to membrane|
|negative regulation of transport|
|protein heterodimerization activity|
|regulation of cell morphogenesis|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|response to nutrient levels|
|positive regulation of multi-organism process|
|regulation of anatomical structure size|
|response to growth factor|
|response to extracellular stimulus|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|response to wounding|
|behavior|
|cellular response to organonitrogen compound|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of multi-organism process|
|ion homeostasis|
|regulation of secretion|
|cellular homeostasis|
|regulation of cellular localization|
|response to organic cyclic compound|
|cell migration|
|sensory perception|
|positive regulation of transport|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|mitochondrion|
|locomotion|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.91|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.76|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.72|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|1.89|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15848
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='P2RY1 Expression in NALM6 Cells: -3.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>