======= P2RY12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: P2RY12
  * **<color #00a2e8>Official Name</color>**: purinergic receptor P2Y12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64805|64805]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H244|Q9H244]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=P2RY12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20P2RY12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600515|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation. {ECO:0000269|PubMed:11104774, ECO:0000269|PubMed:11196645, ECO:0000269|PubMed:11502873, ECO:0000269|PubMed:12578987, ECO:0000269|PubMed:24670650, ECO:0000269|PubMed:24784220}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|initiation of movement involved in cerebral cortex radial glia guided migration|
|cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration|
|cell body membrane|
|positive regulation of integrin activation by cell surface receptor linked signal transduction|
|microglial cell migration|
|ADP receptor activity|
|calcium-mediated signaling using extracellular calcium source|
|G protein-coupled adenosine receptor activity|
|positive regulation of microglial cell migration|
|cell motility involved in cerebral cortex radial glia guided migration|
|regulation of microglial cell migration|
|positive regulation of integrin activation|
|negative regulation of norepinephrine secretion|
|adenosine receptor signaling pathway|
|positive regulation of glial cell migration|
|cell projection membrane|
|substrate-dependent cell migration, cell extension|
|intrinsic component of membrane|
|G protein-coupled purinergic nucleotide receptor activity|
|regulation of integrin activation|
|G protein-coupled purinergic nucleotide receptor signaling pathway|
|regulation of glial cell migration|
|negative regulation of catecholamine secretion|
|positive regulation of ruffle assembly|
|regulation of norepinephrine secretion|
|cellular response to ATP|
|macrophage migration|
|G protein-coupled purinergic receptor signaling pathway|
|positive regulation of cell adhesion mediated by integrin|
|positive regulation of macrophage migration|
|purinergic nucleotide receptor signaling pathway|
|cerebral cortex radial glia guided migration|
|telencephalon glial cell migration|
|negative regulation of amine transport|
|substrate-dependent cell migration|
|purinergic receptor signaling pathway|
|cerebral cortex radially oriented cell migration|
|regulation of ruffle assembly|
|activation of phospholipase C activity|
|response to ATP|
|positive regulation of phosphatidylinositol 3-kinase activity|
|basal plasma membrane|
|lamellipodium assembly|
|glial cell migration|
|positive regulation of lipid kinase activity|
|regulation of macrophage migration|
|protein kinase B signaling|
|lamellipodium organization|
|cerebral cortex cell migration|
|positive regulation of phospholipase C activity|
|platelet aggregation|
|regulation of cell adhesion mediated by integrin|
|regulation of phospholipase C activity|
|positive regulation of phospholipid metabolic process|
|response to axon injury|
|regulation of phosphatidylinositol 3-kinase activity|
|telencephalon cell migration|
|positive regulation of phospholipase activity|
|homotypic cell-cell adhesion|
|forebrain cell migration|
|regulation of lipid kinase activity|
|regulation of catecholamine secretion|
|cellular response to nutrient|
|positive regulation of gliogenesis|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|caveola|
|cell|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|regulation of phospholipid metabolic process|
|regulation of amine transport|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of lipase activity|
|positive regulation of plasma membrane bounded cell projection assembly|
|guanyl-nucleotide exchange factor activity|
|regulation of gliogenesis|
|cerebral cortex development|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|response to organophosphorus|
|platelet activation|
|positive regulation of lipid metabolic process|
|calcium-mediated signaling|
|response to purine-containing compound|
|potassium ion transmembrane transport|
|positive regulation of protein kinase B signaling|
|potassium ion transport|
|ameboidal-type cell migration|
|pallium development|
|regulation of leukocyte migration|
|calcium ion transmembrane transport|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|negative regulation of secretion by cell|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of chemotaxis|
|gliogenesis|
|response to nutrient|
|regulation of protein kinase B signaling|
|negative regulation of secretion|
|cellular response to nutrient levels|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|positive regulation of protein complex assembly|
|regulation of calcium ion transport|
|calcium ion transport|
|telencephalon development|
|cellular response to extracellular stimulus|
|positive regulation of ion transport|
|blood coagulation|
|coagulation|
|divalent metal ion transport|
|hemostasis|
|divalent inorganic cation transport|
|cellular response to external stimulus|
|second-messenger-mediated signaling|
|visual system development|
|sensory system development|
|leukocyte migration|
|positive regulation of cell projection organization|
|forebrain development|
|regulation of metal ion transport|
|external side of plasma membrane|
|regulation of lipid metabolic process|
|monovalent inorganic cation transport|
|positive regulation of cell adhesion|
|cellular response to drug|
|plasma membrane bounded cell projection assembly|
|regulation of protein complex assembly|
|cell projection assembly|
|positive regulation of neurogenesis|
|wound healing|
|negative regulation of transport|
|regulation of body fluid levels|
|response to nutrient levels|
|positive regulation of cell migration|
|cell-cell adhesion|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|response to extracellular stimulus|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|cellular response to organic cyclic compound|
|positive regulation of locomotion|
|inorganic cation transmembrane transport|
|response to wounding|
|positive regulation of kinase activity|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|cation transmembrane transport|
|cell surface|
|metal ion transport|
|inorganic ion transmembrane transport|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|brain development|
|regulation of secretion by cell|
|positive regulation of hydrolase activity|
|head development|
|regulation of secretion|
|regulation of neurogenesis|
|cation transport|
|regulation of cell migration|
|regulation of kinase activity|
|regulation of cell motility|
|response to organic cyclic compound|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|ion transmembrane transport|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|response to drug|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|regulation of response to external stimulus|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|mitochondrion|
|regulation of hydrolase activity|
|transmembrane transport|
|locomotion|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|ion transport|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|neurogenesis|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9769
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='P2RY12 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>