======= PABPC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PABPC1
  * **<color #00a2e8>Official Name</color>**: poly(A) binding protein cytoplasmic 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26986|26986]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11940|P11940]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PABPC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PABPC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604679|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). Positively regulates the replication of dengue virus (DENV) (PubMed:26735137). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:26735137}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PABP|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|translation activator activity|
|regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|poly(A) binding|
|mRNA polyadenylation|
|poly(U) RNA binding|
|RNA polyadenylation|
|positive regulation of viral genome replication|
|mRNA stabilization|
|RNA stabilization|
|positive regulation of mRNA catabolic process|
|negative regulation of mRNA catabolic process|
|negative regulation of RNA catabolic process|
|positive regulation of viral life cycle|
|cytoplasmic stress granule|
|cytoplasmic ribonucleoprotein granule|
|mRNA 3-UTR binding|
|positive regulation of mRNA metabolic process|
|negative regulation of mRNA metabolic process|
|mRNA 3-end processing|
|catalytic step 2 spliceosome|
|gene silencing by RNA|
|regulation of viral genome replication|
|positive regulation of viral process|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|positive regulation of translation|
|RNA 3-end processing|
|translational initiation|
|regulation of viral life cycle|
|positive regulation of cellular amide metabolic process|
|gene silencing|
|ribonucleoprotein complex|
|regulation of mRNA stability|
|regulation of RNA stability|
|protein C-terminus binding|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|regulation of viral process|
|mRNA catabolic process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|RNA catabolic process|
|negative regulation of cellular catabolic process|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|negative regulation of catabolic process|
|regulation of mRNA metabolic process|
|regulation of translation|
|positive regulation of cellular catabolic process|
|nucleobase-containing compound catabolic process|
|translation|
|RNA splicing|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|focal adhesion|
|positive regulation of catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|mRNA processing|
|organic cyclic compound catabolic process|
|positive regulation of multi-organism process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|regulation of multi-organism process|
|cellular amide metabolic process|
|regulation of cellular catabolic process|
|RNA processing|
|cellular macromolecule catabolic process|
|regulation of catabolic process|
|macromolecule catabolic process|
|negative regulation of RNA metabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.96|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.72|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.77|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.91|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.06|
|[[:results:exp495|IWR1 50μM R08 exp495]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 369/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|13/28|
|blood|11/28|
|bone|18/26|
|breast|12/33|
|central nervous system|40/56|
|cervix|1/4|
|colorectal|10/17|
|esophagus|6/13|
|fibroblast|1/1|
|gastric|6/16|
|kidney|7/21|
|liver|10/20|
|lung|42/75|
|lymphocyte|11/16|
|ovary|13/26|
|pancreas|15/24|
|peripheral nervous system|12/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|8/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|10/22|
|urinary tract|17/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1534
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 11.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PABPC1 Expression in NALM6 Cells: 11.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>